Potential biomarkers for disease activity in Takayasu's arteritis

Abstract Background Anemia is a common clinical condition in autoimmune disease, but there are few related studies in Takayasu’s arteritis (TAK). The purpose of this study is to detect clinical characteristics of anemia patients with TAK and to explore the relationship between the hemoglobin level and the disease activity in TAK. Methods This retrospective study included 160 cases of hospitalized patients with TAK and 110 cases of age-and sex-matched healthy people. According to the hemoglobin level, 160 TAK patients were divided into two groups with and without anemia, the immune indexes were compared between the two groups. 28 patients with anemia in TAK were followed up and the changes of immune indexes before and after treatment were compared.Results Hemoglobin in TAK patients is significantly lower than that of healthy control group. Among the 160 cases of TAK, 67 cases of anemia are mild to moderate anemia, and most of which are normocytic anemia. In anemia patients with TAK, women was more common (P=0.014), age at admission was more younger (P=0.002), the disease duration was shorter (P=0.017). The levels of erythrocyte sedimentation rate (ESR, P=0.000), C-reactive protein (CRP, P=0.000), interleukin-6 (IL-6, P=0.036) and disease activity scores (NIH P=0.000, ITASA P=0.001, ITAS2010 P=0.030) were significantly higher in anemia patients with TAK. The risk of anemia in TAK patients with elevated CRP was 2.35 times than that of TAK patients without elevated CRP (OR = 2.350, 95% CI 1.055-5.234, P = 0.037). After followed up for 3-6 months, hemoglobin levels increased significantly (P=0.001), ESR (P=0.000), CRP (P=0.039) and disease activity scores (NIH P=0.001, ITASA P=0.000, ITAS2010 P=0.000) decreased significantly through effective treatment without iron supplementation, and the changes of hemoglobin after treatment were negatively correlated with the changes of ESR (P=0.046) and CRP (P=0.002).Conclusion Anemia patients with TAK were more common in young women, and the disease activity was higher. Anemia can be significantly improved without iron supplementation through effective treatment to reduce disease activity of TAK.

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MONOCYTE TO LYMPHOCYTE RATIO AND PLATELET TO LYMPHOCYTE RATIO AS A PREDICTOR OF DISEASE ACTIVITY IN TAKAYASU’S ARTERITIS

10.5151/sbr2019-515 ◽

2019 ◽

Author(s):

RENAN RODRIGUES NEVES RIBEIRO DO NASCIMENTO ◽

DANIEL VIANA SILVA E SILVA ◽

RAQUEL MITIE KANNO ◽

LUIZA SÁ E RÊGO TUPINAMBÁ ◽

MARIANA DAVIM FERREIRA GOMES ◽

...

Keyword(s):

Disease Activity ◽

Takayasu’S Arteritis ◽

Takayasu's Arteritis ◽

Platelet To Lymphocyte Ratio ◽

Lymphocyte Ratio

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Magnetic Resonance Angiography and Multidetector CT Angiography in the Diagnosis of Takayasu’s Arteritis: Assessment of Disease Extent and Correlation with Disease Activity

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405617666210707154059 ◽

2021 ◽

Vol 17 ◽

Author(s):

Kalyan Sarma ◽

Akash Handique ◽

Pranjal Phukan ◽

C Daniala ◽

Happy Chutia ◽

...

Keyword(s):

Magnetic Resonance ◽

Magnetic Resonance Angiography ◽

Disease Activity ◽

Ct Angiography ◽

Subclavian Artery ◽

Clinical Presentation ◽

Takayasu’S Arteritis ◽

Left Vertebral Artery ◽

Mediastinal Lymphadenopathy ◽

Takayasu's Arteritis

Background: Takayasu’s arteritis (TA) is a large vessel vasculitis with diverse clinical presentations and arterial vascular bed involvement. It is characterized by chronic, nonspecific inflammation of all layers of the vessel wall, which results in stenosis, occlusion, dilatation, or aneurysm formation in the involved blood vessels. Methods: The study included 36 patients of TA. All patients fulfilled the modified Ishikawa’s diagnostic criteria for TA. All patients were evaluated for clinical presentation, angiographic findings, and severity of the disease. The disease activity was assessed based on Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and also by CT angiography (CTA)/Magnetic resonance angiography (MRA) imaging. The angiographic types were classified based on the International TA Conference in Tokyo, 1994 angiographic classification. Results: total of 36 patients were included in the study, 86% were females and a mean age of 21.6 years. Hypertension (78%) was the most common clinical presentation. Type V was the most common angiographic type (42%), followed by type III (25%), type IV (14%), type IIb (11%), type I (5%) and type IIa (3%). Among the aortic arch branches, the left subclavian artery (50%), right subclavian artery (38.8%), left vertebral artery (33.3%) and left common carotid artery (27.7%) were the most commonly involved arteries. Disease activity based on CT/MR imaging showed a significant statistical correlation with elevated ESR and positive CRP (p < 0.0001). Mediastinal lymphadenopathy was seen in 21 patients, out of which 11 had active disease. However, no significant correlation was found between mediastinal lymphadenopathy and disease activity. Conclusions: TA presents varied symptomatology and differing vascular involvement. CT/MR angiography is effective in diagnosis and accurately predicted the active stage of the disease.

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