VEGF-A promotes cardiac stem cell engraftment and myocardial repair in the infarcted heart

2015 ◽  
Vol 183 ◽  
pp. 221-231 ◽  
Author(s):  
Jun-Ming Tang ◽  
Bin Luo ◽  
Jun-hui Xiao ◽  
Yan-xia Lv ◽  
Xiao-lin Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cardiac Stem Cell ◽  
Myocardial Repair ◽  
Infarcted Heart ◽  
Cell Engraftment

scholarly journals VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart

2011 ◽  
Vol 91 (3) ◽  
pp. 402-411 ◽  
Author(s):  
Jun-Ming Tang ◽  
Jia-Ning Wang ◽  
Lei Zhang ◽  
Fei Zheng ◽  
Jian-Ye Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Mobilization ◽  
Cardiac Stem Cell ◽  
Myocardial Repair ◽  
Infarcted Heart ◽  
Cell Mobilization

scholarly journals Improving Cell Engraftment in Cardiac Stem Cell Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Xiaofei Li ◽  
Kenichi Tamama ◽  
Xiaoyun Xie ◽  
Jianjun Guan
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Cell Survival ◽  
Stem Cell Therapy ◽  
Heart Function ◽  
Immune Surveillance ◽  
Heart Tissue ◽  
Cardiac Stem Cell ◽  
Cell Retention ◽  
Cell Engraftment

Myocardial infarction (MI) affects millions of people worldwide. MI causes massive cardiac cell death and heart function decrease. However, heart tissue cannot effectively regenerate by itself. While stem cell therapy has been considered an effective approach for regeneration, the efficacy of cardiac stem cell therapy remains low due to inferior cell engraftment in the infarcted region. This is mainly a result of low cell retention in the tissue and poor cell survival under ischemic, immune rejection and inflammatory conditions. Various approaches have been explored to improve cell engraftment: increase of cell retention using biomaterials as cell carriers; augmentation of cell survival under ischemic conditions by preconditioning cells, genetic modification of cells, and controlled release of growth factors and oxygen; and enhancement of cell survival by protecting cells from excessive inflammation and immune surveillance. In this paper, we review current progress, advantages, disadvantages, and potential solutions of these approaches.

Improved Function and Myocardial Repair of Infarcted Heart by Intracoronary Injection of Mesenchymal Stem Cell-Derived Growth Factors

2010 ◽  
Vol 3 (5) ◽  
pp. 547-558 ◽  
Author(s):  
Ba-Khoi Nguyen ◽  
Simon Maltais ◽  
Louis P. Perrault ◽  
Jean-François Tanguay ◽  
Jean-Claude Tardif ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factors ◽  
Mesenchymal Stem Cell ◽  
Myocardial Repair ◽  
Intracoronary Injection ◽  
Infarcted Heart ◽  
Improved Function

CardioClusters: Enhancing Stem Cell Engraftment and Myocardial Repair

2018 ◽  
Vol 124 ◽  
pp. 85
Author(s):  
Megan Monsanto ◽  
Bingyan Wang ◽  
Zach Ehrenberg ◽  
Roberto Alvarez ◽  
Mark Sussman
Keyword(s):  
Stem Cell ◽  
Myocardial Repair ◽  
Cell Engraftment

scholarly journals Cardiac Stem Cell Hybrids Enhance Myocardial Repair

2015 ◽  
Vol 117 (8) ◽  
pp. 695-706 ◽  
Author(s):  
Pearl Quijada ◽  
Hazel T. Salunga ◽  
Nirmala Hariharan ◽  
Jonathan D. Cubillo ◽  
Farid G. El-Sayed ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cardiac Stem Cell ◽  
Myocardial Repair ◽  
Cell Hybrids

scholarly journals Bmi1 and BRG1 drive myocardial repair by regulating cardiac stem cell function in acute rheumatic heart disease

2017 ◽  
Vol 14 (4) ◽  
pp. 3812-3816
Author(s):  
Pingxi Xiao ◽  
Kai Zhang ◽  
Zhiwen Tao ◽  
Niannian Liu ◽  
Bangshun Ge ◽  
...  
Keyword(s):  
Stem Cell ◽  
Heart Disease ◽  
Rheumatic Heart Disease ◽  
Cell Function ◽  
Cardiac Stem Cell ◽  
Myocardial Repair ◽  
Rheumatic Heart

Sternal bone marrow is a suitable autologous cell source for cardiac stem cell therapies

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
M. Arar ◽  
A. Rotärmel ◽  
A.-K. Knoefel ◽  
H. Baraki ◽  
I. Kutschka ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cardiac Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Autologous Cell ◽  
Cell Source
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