scholarly journals Improving Cell Engraftment in Cardiac Stem Cell Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Xiaofei Li ◽  
Kenichi Tamama ◽  
Xiaoyun Xie ◽  
Jianjun Guan
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Cell Survival ◽  
Stem Cell Therapy ◽  
Heart Function ◽  
Immune Surveillance ◽  
Heart Tissue ◽  
Cardiac Stem Cell ◽  
Cell Retention ◽  
Cell Engraftment

Myocardial infarction (MI) affects millions of people worldwide. MI causes massive cardiac cell death and heart function decrease. However, heart tissue cannot effectively regenerate by itself. While stem cell therapy has been considered an effective approach for regeneration, the efficacy of cardiac stem cell therapy remains low due to inferior cell engraftment in the infarcted region. This is mainly a result of low cell retention in the tissue and poor cell survival under ischemic, immune rejection and inflammatory conditions. Various approaches have been explored to improve cell engraftment: increase of cell retention using biomaterials as cell carriers; augmentation of cell survival under ischemic conditions by preconditioning cells, genetic modification of cells, and controlled release of growth factors and oxygen; and enhancement of cell survival by protecting cells from excessive inflammation and immune surveillance. In this paper, we review current progress, advantages, disadvantages, and potential solutions of these approaches.

scholarly journals Current Perspectives on Imaging Cardiac Stem Cell Therapy

2010 ◽  
Vol 51 (Supplement_1) ◽  
pp. 128S-136S ◽  
Author(s):  
J. C. Wu ◽  
M. R. Abraham ◽  
D. L. Kraitchman
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cardiac Stem Cell

scholarly journals Optimized Cell Survival and Seeding Efficiency for Craniofacial Tissue Engineering Using Clinical Stem Cell Therapy

2014 ◽  
Vol 3 (12) ◽  
pp. 1495-1503 ◽  
Author(s):  
Archana Rajan ◽  
Emily Eubanks ◽  
Sean Edwards ◽  
Sharon Aronovich ◽  
Suncica Travan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Cell Therapy ◽  
Cell Survival ◽  
Stem Cell Therapy ◽  
Craniofacial Tissue ◽  
Seeding Efficiency

The Promise and Challenges of Cardiac Stem Cell Therapy

2014 ◽  
Vol 26 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Nathan C. Ni ◽  
Ren-Ke Li ◽  
Richard D. Weisel
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cardiac Stem Cell

scholarly journals Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-Implants

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Alice Le Friec ◽  
Anne-Sophie Salabert ◽  
Carole Davoust ◽  
Boris Demain ◽  
Christophe Vieu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Spontaneous Recovery ◽  
Brain Structures ◽  
Acquired Disability ◽  
Central Nervous System Drugs ◽  
Cell Engraftment ◽  
The Central Nervous System ◽  
Novel Drug

Stroke represents the first cause of adult acquired disability. Spontaneous recovery, dependent on endogenous neurogenesis, allows for limited recovery in 50% of patients who remain functionally dependent despite physiotherapy. Here, we propose a review of novel drug therapies with strong potential in the clinic. We will also discuss new avenues of stem cell therapy in patients with a cerebral lesion. A promising future for the development of efficient drugs to enhance functional recovery after stroke seems evident. These drugs will have to prove their efficacy also in severely affected patients. The efficacy of stem cell engraftment has been demonstrated but will have to prove its potential in restoring tissue function for the massive brain lesions that are most debilitating. New answers may lay in biomaterials, a steadily growing field. Biomaterials should ideally resemble lesioned brain structures in architecture and must be proven to increase functional reconnections within host tissue before clinical testing.

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