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2021 ◽  
Vol 37 (3) ◽  
pp. 349-361
Author(s):  
Daniel F. Waters ◽  
Lucas M. Pratt ◽  
Christopher P. Cadou

2019 ◽  
Vol 42 (1) ◽  
pp. 273-284
Author(s):  
Mark C. Williams ◽  
Wolfgang Winkler ◽  
Ai Suzuki ◽  
Akira Miyamoto
Keyword(s):  

2018 ◽  
Vol 2 (3) ◽  
pp. 031907 ◽  
Author(s):  
Casey A. Chitwood ◽  
Claire Dietzsch ◽  
Gabriel Jacobs ◽  
Tanner McArdle ◽  
Brian T. Freeman ◽  
...  

Cytotherapy ◽  
2016 ◽  
Vol 18 (4) ◽  
pp. 570-580 ◽  
Author(s):  
Mariana Pereira Pinho ◽  
Bala Sai Sundarasetty ◽  
Patricia Cruz Bergami-Santos ◽  
Karen Steponavicius-Cruz ◽  
Adilson Kleber Ferreira ◽  
...  

2015 ◽  
Vol 117 (8) ◽  
pp. 695-706 ◽  
Author(s):  
Pearl Quijada ◽  
Hazel T. Salunga ◽  
Nirmala Hariharan ◽  
Jonathan D. Cubillo ◽  
Farid G. El-Sayed ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jens Dannull ◽  
Chunrui Tan ◽  
Christine Farrell ◽  
Cynthia Wang ◽  
Scott Pruitt ◽  
...  

Background. Dendritic cell- (DC-) tumor fusion cells stimulate effectivein vivoantitumor responses. However, therapeutic approaches are dependent upon the coadministration of exogenous 3rd signals. The purpose of this study was to determine the mechanisms for inadequate 3rd signaling by electrofused DC-tumor cell hybrids.Methods. Murine melanoma cells were fused with DCs derived from C57BL/6 mice. Quantitative real-time PCR (qPCR) was used to determine relative changes in Th (T helper) 1 and Th2 cytokine gene expression. In addition, changes in gene expression of fusion cells were determined by microarray. Last, cytokine secretion by fusion cells upon inhibition of signaling pathways was analyzed by ELISA.Results. qPCR analyses revealed that fusion cells exhibited a downregulation of Th1 associated cytokines IL-12 and IL-15 and an upregulation of the Th2 cytokine IL-4. Microarray studies further showed that the expression of chemokines, costimulatory molecules, and matrix-metalloproteinases was deregulated in fusion cells. Lastly, inhibitor studies demonstrate that inhibition of the PI3K/Akt/mTOR signaling pathway could restore the secretion of bioactive IL-12p70 by fusion cells.Conclusion. Our results suggest that combining fusion cell-based vaccination with administration of inhibitors of the PI3K/Akt/mTOR signaling pathway may enhance antitumor responses in patients.


2014 ◽  
Vol 16 (3) ◽  
pp. 167-174 ◽  
Author(s):  
Huseyin Sumer ◽  
Kitai Kim ◽  
Jun Liu ◽  
Kitwa Ng ◽  
George Q. Daley ◽  
...  

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