Background:
Intraluminal coronary morphology is traditionally evaluated by Intravascular Ultrasound (IVUS). Frequency Domain Optical Coherence Tomography (FD-OCT) is a novel method for evaluation of coronary lumen dimensions. Current literature has paucity of data with limited sample size comparing FD-OCT to IVUS. The objective of this meta-analysis is to compare the FD-OCT versus IVUS in assessment of lumen dimensions in non-stented and stented coronary arteries.
Methods:
PubMed and the Cochrane Center Register of Controlled Trials were searched through January 2015. Seven studies (n=169 vessels) comparing FD-OCT versus IVUS procedures in assessing lumen dimensions in non-stented and stented coronary arteries were included. Outcomes were minimum lumen area, minimum lumen diameter and maximum lumen diameter. The mean difference (MD) with 95% confidence interval (CI) was computed and p<0.05 was considered as a level of significance.
Results:
FD-OCT measured significantly smaller minimum lumen area and maximum lumen diameter compared to IVUS in non-stented vessels (MD: -0.86 mm
2
, CI: -1.18 to -0.55, p<0.00001 and MD: -0.21 mm, CI: -0.35 to -0.06, p=0.006, respectively). Minimum lumen diameter was not significantly different between two groups in non-stented coronary arteries (p=0.21). In stented vessels, no significant difference was found in measurement of minimum lumen area (p=0.34) and minimum lumen diameter (p=0.41) between FD-OCT and IVUS.
Conclusion:
The results of this study suggest that FD-OCT maybe a better modality to evaluate the severity of stenosis in non-stented coronary arteries. FD-OCT is comparable to IVUS in measuring lumen dimensions in stented vessels.
Discrepancy between frequency domain optical coherence tomography and intravascular ultrasound in human coronary arteries and in a phantom in vitro coronary model
