Safety and usefulness of acetylcholine provocation test in patients with no culprit lesions on emergency coronary angiography

2018 ◽  
Vol 269 ◽  
pp. 27-30 ◽  
Author(s):  
Kazuya Tateishi ◽  
Yuichi Saito ◽  
Hideki Kitahara ◽  
Toshihiro Shoji ◽  
Tadayuki Kadohira ◽  
...  
2018 ◽  
Vol 71 (11) ◽  
pp. A138
Author(s):  
Kazuya Tateishi ◽  
Hideki Kitahara ◽  
Yuichi Saitoh ◽  
Tadayuki Kadihira ◽  
Takashi Nakayama ◽  
...  

2011 ◽  
Vol 38 (12) ◽  
pp. 819-823 ◽  
Author(s):  
Ji Young Park ◽  
Seung-Woon Rha ◽  
Zhe Jin ◽  
Kanhaiya L Poddar ◽  
Sureshkumar Ramasamy ◽  
...  

2009 ◽  
Vol 103 (9) ◽  
pp. 89B
Author(s):  
Seung-Woon Rha ◽  
Kanhaiya Lal Poddar ◽  
Kang Yin Chen ◽  
Yong Jian Li ◽  
Yoshiyasu Minami ◽  
...  

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Daisuke Tomioka ◽  
Koichi Kato ◽  
Tomoya Ozawa ◽  
Kenji Kodama ◽  
Hiroaki Takahashi ◽  
...  

Abstract Background Anderson–Fabry disease (AFD) is an X-linked lysosomal storage disorder resulting from a mutation of alpha-galactosidase A gene (GLA), causing deficiency in alpha-galactosidase activity. The enzyme deficit can lead to storage of globotriaosylceramide in various organs including heart. Studies suggest that vasospastic angina (VSA) is associated with AFD. Case summary This clinical case series aimed to present two female patients with AFD, including progressive cardiac involvement: a 50-year-old woman (patient number 1) and a 39-year-old woman (patient number 2) who are siblings with a male AFD patient harbouring p. Arg342Glu missense variant in alpha-galactosidase A gene (GLA), who suffered VSA and subsequent ventricular fibrillation. Enzymatic tests and genetic analysis confirmed AFD in both female patients and histological tests revealed globotriaosylceramide deposits in their hearts. In patient number 1, a 12-lead electrocardiography and transthoracic echocardiography revealed cardiac hypertrophy. Coronary angiography revealed no organic coronary artery stenosis and vasospasms was induced by spasm provocation test. In patient number 2, no signs of cardiac hypertrophy were found, and coronary arteries had no organic stenosis with negative spasm provocation test. Both patients received enalapril therapy and enzyme replacement therapy (ERT). Discussion Different phenotype of AFD was occurred even with the same genetic variant in female heterozygote patients. The duration of exposing accumulation of Gb3 might affect cardiac hypertrophy and vasospasms. Coronary angiography with acetylcholine provocation test should be considered in female AFD patient, especially in case with cardiac hypertrophy.


2014 ◽  
Vol 30 (4) ◽  
pp. 372-376 ◽  
Author(s):  
Yasuhiro Tanabe ◽  
Kihei Yoneyama ◽  
Masaki Izumo ◽  
Ken Kongoji ◽  
Tomoo Harada ◽  
...  

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