Repeated ethanol exposure during adolescence alters the developmental trajectory of dopaminergic output from the nucleus accumbens septi

2009 ◽  
Vol 27 (8) ◽  
pp. 805-815 ◽  
Author(s):  
Rex M. Philpot ◽  
Lynn Wecker ◽  
Cheryl L. Kirstein
2013 ◽  
Vol 65 (3) ◽  
pp. 566-578 ◽  
Author(s):  
Luis H. Llano López ◽  
Fernando Caif ◽  
Miriam Fraile ◽  
Belén Tinnirello ◽  
Adriana I. Landa de Gargiulo ◽  
...  

2018 ◽  
Vol 29 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Augusto P.I. Gargiulo ◽  
María P. Gargiulo De Aranda ◽  
Mercedes M.L. Gargiulo ◽  
Angel J.M. Gargiulo ◽  
Andres Acuña ◽  
...  

AbstractBackground:In previous studies, we have observed that specificN-methyl-d-aspartic acid (NMDA) antagonists and non-NMDA antagonists injected within the nucleus accumbens septi (NAS) induced an anxiolytic-like effect in the plus maze test in rats. In the present study, the effect of intracanalicular blockade of NMDA receptors using dizocilpine in the plus maze was studied in male rats bilaterally cannulated NAS.Methods:Rats were divided into five groups that received either 1 μL injections of saline or dizocilpine (MK-801, [5R,10S]-[+]-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine) in different doses (0.5, 1, 2, or 4 μg) 15 min before testing.Results:Time spent in the open arm increased under dizocilpine treatment with the two higher doses (2 and 4 μg, p<0.05), extreme arrivals were increased by the three higher doses (1 μg, p<0.05; 2 and 4 μg, p<0.01), and open arm entries by the three higher doses (1, 2, and 4 μg, p<0.05). A dose-effect relationship was observed in all cases.Conclusions:We conclude that dizocilpine-glutamatergic blockade in the accumbens lead to an anxiolytic-like effect and a behavioral disinhibition related to an increase in some motoric parameters, showing specific behavioral patterns.


1980 ◽  
Vol 185 (1) ◽  
pp. 183-186 ◽  
Author(s):  
J.F. DeFrance ◽  
J.E. Marchand ◽  
J.C. Stanley ◽  
R.W. Sikes ◽  
R.B. Chronister

Author(s):  
R. Stefański ◽  
A. Plaznik ◽  
W. Pałejko ◽  
W. Kostowski

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