Cerebral blood volume measurement using near‐infrared time‐resolved spectroscopy and histopathological evaluation after hypoxic‐ischemic insult in newborn piglets

2015 ◽  
Vol 42 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Makoto Nakamura ◽  
Wataru Jinnai ◽  
Satoshi Hamano ◽  
Shinji Nakamura ◽  
Kosuke Koyano ◽  
...  
Keyword(s):  
Blood Volume ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Volume Measurement ◽  
Ischemic Insult ◽  
Time Resolved ◽  
Time Resolved Spectroscopy ◽  
Newborn Piglets ◽  
Histopathological Evaluation ◽  
Blood Volume Measurement

Noninvasive cerebral blood volume measurement during seizures using multichannel near infrared spectroscopic topography

2000 ◽  
Vol 5 (3) ◽  
pp. 287 ◽  
Author(s):  
Eiju Watanabe ◽  
Atsushi Maki ◽  
Fumio Kawaguchi ◽  
Yuichi Yamashita ◽  
Hideaki Koizumi ◽  
...  
Keyword(s):  
Blood Volume ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Volume Measurement ◽  
Infrared Spectroscopic ◽  
Blood Volume Measurement

scholarly journals Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tsutomu Mitsuie ◽  
Shinji Nakamura ◽  
Yinmon Htun ◽  
Yasuhiro Nakao ◽  
Makoto Arioka ◽  
...  
Keyword(s):  
Blood Volume ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Brain Injuries ◽  
Time Resolved ◽  
Time Resolved Spectroscopy ◽  
The Difference ◽  
The Relationship ◽  
Inspired Oxygen ◽  
Ischemic Encephalopathy

AbstractNeonatal hypoxic–ischemic encephalopathy is a notable cause of neonatal death and developmental disabilities. To achieve better outcomes, it is important in treatment strategy selection to categorize the degree of hypoxia ischemia and evaluate dose response. In an asphyxia piglet model with histopathological brain injuries that we previously developed, animals survived 5 days after insult and showed changes in cerebral blood volume (CBV) that reflected the severity of injuries. However, little is known about the relationship between changes in CBV during and after insult. In this study, an HI event was induced by varying the amount and timing of inspired oxygen in 20 anesthetized piglets. CBV was measured using near-infrared time-resolved spectroscopy before, during, and 6 h after insult. Change in CBV was calculated as the difference between the peak CBV value during insult and the value at the end of insult. The decrease in CBV during insult was found to correlate with the increase in CBV within 6 h after insult. Heart rate exhibited a similar tendency to CBV, but blood pressure did not. Because the decrement in CBV was larger in severe HI, the CBV increment immediately after insult is considered useful for assessing degree of HI insult.

Noninvasive cerebral blood volume measurement during seizures using multichannel near infrared spectroscopic topography

1998 ◽  
Vol 11 (6) ◽  
pp. 335-340 ◽  
Author(s):  
Eiju Watanabe ◽  
Atsushi Maki ◽  
Fumio Kawaguchi ◽  
Yuichi Yamashita ◽  
Hideaki Koizumi ◽  
...  
Keyword(s):  
Blood Volume ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Volume Measurement ◽  
Infrared Spectroscopic ◽  
Blood Volume Measurement

scholarly journals Measurement of the Absolute Value of Cerebral Blood Volume and Optical Properties in Term Neonates Immediately after Birth Using Near-Infrared Time-Resolved Spectroscopy: A Preliminary Observation Study

2019 ◽  
Vol 9 (10) ◽  
pp. 2172 ◽  
Author(s):  
Aya Morimoto ◽  
Shinji Nakamura ◽  
Masashiro Sugino ◽  
Kosuke Koyano ◽  
Yinmon Htun ◽  
...  
Keyword(s):  
Optical Properties ◽  
Blood Volume ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Transition Period ◽  
Observation Study ◽  
Time Resolved ◽  
Term Neonates ◽  
Time Resolved Spectroscopy ◽  
The Absolute

The aim of this study was to use near-infrared time-resolved spectroscopy (TRS) to determine the absolute values of cerebral blood volume (CBV) and cerebral hemoglobin oxygen saturation (ScO2) during the immediate transition period in term neonates and the changes in optical properties such as the differential pathlength factor (DPF) and reduced scattering coefficient (μs’). CBV and ScO2 were measured using TRS during the first 15 min after birth by vaginal delivery in term neonates who did not need resuscitation. Within 2–3 min after birth, CBV showed various changes such as increases or decreases, followed by a gradual decrease until 15 min and then stability (mean (SD) mL/100 g brain: 2 min, 3.09 (0.74); 3 min, 3.01 (0.77); 5 min, 2.69 (0.77); 10 min, 2.40 (0.61), 15 min, 2.08 (0.47)). ScO2 showed a gradual increase, then kept increasing or became a stable reading. The DPF and μs’ values (mean (SD) at 762, 800, and 836 nm) were stable during the first 15 min after birth (DPF: 4.47 (0.38), 4.41 (0.32), and 4.06 (0.28)/cm; μs’: 6.54 (0.67), 5.82 (0.84), and 5.43 (0.95)/cm). Accordingly, we proved that TRS can stably measure cerebral hemodynamics, despite the dramatic physiological changes occurring at this time in the labor room.

scholarly journals Validation of VASO cerebral blood volume measurement with positron emission tomography

2010 ◽  
Vol 65 (3) ◽  
pp. 744-749 ◽  
Author(s):  
Jinsoo Uh ◽  
Ai-Ling Lin ◽  
Kihak Lee ◽  
Peiying Liu ◽  
Peter Fox ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Volume Measurement ◽  
Emission Tomography ◽  
Positron Emission ◽  
Blood Volume Measurement

scholarly journals Non-Invasive Cerebral Blood Volume Measurement during Epilepsy Using Multi-Channel Near Infra-Red Spectroscopic Topography

Epilepsia ◽  
2000 ◽  
Vol 41 (s9) ◽  
pp. 57-58 ◽  
Author(s):  
Eiju Watanabe ◽  
Atsushi Maki ◽  
Yukihiro Nagahori ◽  
Fumio Kawaguchi ◽  
Hideaki Koizumi ◽  
...  
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Volume Measurement ◽  
Non Invasive ◽  
Infra Red ◽  
Blood Volume Measurement

Relationship between Changes in Cerebral Blood Volume During Hypoxic-ischemic Insult and Early Period after Insult

2021 ◽  
Author(s):  
Tsutomu Mitsuie ◽  
Shinji Nakamura ◽  
Yinmon Htun ◽  
Yasuhiro Nakao ◽  
Makoto Arioka ◽  
...  
Keyword(s):  
Blood Volume ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Brain Injuries ◽  
Treatment Strategies ◽  
Early Period ◽  
Additional Treatment ◽  
Time Resolved ◽  
Precise Prediction ◽  
The Difference

Abstract To achieve better outcomes in hypoxic-ischemic encephalopathy, categorizing the degree of the hypoxia-ischemia (HI) is important for selecting suitable candidates for therapeutic hypothermia and any additional treatment strategies. We previously developed a novel model of asphyxiated piglets with a uniform degree of histopathological brain injuries that survived for 5 days after insult and showed changes in cerebral blood volume (CBV) that reflected the severity of the brain injuries. However, little is known about the relationship between changes in CBV during and after insult. In this study, an HI event was induced by low inspired oxygen in 23 anesthetized newborn piglets, including three sham controls. CBV was measured using near-infrared time-resolved spectroscopy (TRS). Data were collected before, during, and 6 h after insult. The change in CBV was calculated as the difference between the peak CBV value during insult and the value at the end of insult. The decrease in CBV during insult was found to correlate with the increase in CBV within 6 h after insult. Heart rate exhibited a similar tendency to CBV but blood pressure did not. The CBV increment immediately after resuscitation provides a relatively precise prediction of the severity of HI insult.

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