Myoepithelial carcinoma of the salivary glands: clinicopathologic features, evaluation of intratumoral microvessel density and analysis of treatment outcomes of 14 cases

Background Epithelial-myoepithelial carcinoma (EMC) is a rare tumor of the major and minor salivary glands. Sinonasal EMC is extremely uncommon and hitherto not described within the frontal or ethmoid sinuses. Objective To present a novel sinonasal subsite and review the literature regarding sinonasal EMC. Methods A case of frontoethmoidal EMC was presented. A medical literature data base was queried from January 1, 1950, to August 8, 2017, for all reports of sinonasal EMC. Results A 69-year-old man underwent combined open and endoscopic craniofacial resection of a right frontoethmoidal EMC, a previously undescribed primary location for this tumor. A comprehensive review of the literature revealed 13 additional cases of sinonasal EMC. Conclusion EMC is an uncommon neoplasm typically found in the major salivary glands; occurrence in the nose or paranasal sinuses is extremely rare. EMC often follows an indolent clinical course, although, in a minority of cases, particularly in large tumors with nuclear atypia, more aggressive behavior may be observed.

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Myoepithelial Carcinoma of the Salivary Glands: Report of an Aggressive Case

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2018.02.047 ◽

2018 ◽

Vol 126 (3) ◽

pp. e44-e45

Author(s):

Tamires Zupirolli Fernandes ◽

Renata Escher Pereira ◽

Bruno Monazzi ◽

Graziela Vieira Cavalcanti ◽

Luiz Carlos Conti De Freitas ◽

...

Keyword(s):

Salivary Glands ◽

Myoepithelial Carcinoma

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Adult soft tissue myoepithelial carcinoma: Treatment outcomes and efficacy of chemotherapy

Annals of Oncology ◽

10.1093/annonc/mdz433.012 ◽

2019 ◽

Vol 30 ◽

pp. ix138-ix139

Author(s):

F.E. Chamberlain ◽

E. Cojocaru ◽

M. Scaranti ◽

J. Noujaim ◽

K. Thway ◽

...

Keyword(s):

Soft Tissue ◽

Treatment Outcomes ◽

Myoepithelial Carcinoma

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Clear Cell Myoepithelial Carcinoma Arising from the Hard Palate with Metastasis to the Lungs

Case Reports in Pathology ◽

10.1155/2019/3863270 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6

Author(s):

Jiayun Fang ◽

Amanda Kornfield ◽

Alex Clavijo ◽

Shikhar Vyas ◽

Alison Ulbrandt ◽

...

Keyword(s):

Parotid Gland ◽

Aggressive Behavior ◽

Salivary Glands ◽

Hard Palate ◽

Clear Cell ◽

Pulmonary Nodules ◽

Myoepithelial Carcinoma ◽

Elderly Male ◽

Resection Specimen ◽

Uncommon Tumor

Myoepithelial carcinoma is an uncommon tumor of the salivary glands, most commonly the parotid gland. Clear cell myoepithelial carcinoma is a rare variant with an aggressive behavior. Here, we describe a case of clear cell myoepithelial carcinoma arising from the hard palate in an elderly male who underwent resection of the tumor and postop radiation. Posttreatment imaging demonstrated bilateral pulmonary nodules and a C2 body lesion concerning for metastasis. Biopsy of the lung lesions revealed a monomorphous population of optically clear cells with hyperchromatic and pleomorphic nuclei which were morphologically similar to the prior resection specimen. There are few reported cases of clear cell myoepithelial carcinoma arising from the hard palate, and there are even fewer reports on metastases to the lungs. Due to the low number of reported cases, prognosis and treatment of this neoplasm is not well defined.

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