Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: Preparation, characterization and efficacy in Parkinson's disease

2011 ◽  
Vol 415 (1-2) ◽  
pp. 273-283 ◽  
Author(s):  
Kaili Hu ◽  
Yanbin Shi ◽  
Wenming Jiang ◽  
Jiaying Han ◽  
Shixian Huang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Plga Nanoparticles ◽  
Brain Delivery

GOCOVRI® (amantadine) extended-release capsules in Parkinson's disease

2021 ◽  
Author(s):  
Thomas Müller
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Extended Release ◽  
Motor Behavior ◽  
Brain Delivery ◽  
Antiviral Compound ◽  
Once Daily ◽  
Beneficial Effects ◽  
Central Monoamine ◽  
Preventive Effects

Amantadine is an old, antiviral compound, which moderately improves motor behavior in Parkinson's disease. Its current resurgence results from an innovative, delayed uptake and extended release amantadine hydrochloride capsule, given at bedtime once daily. It is the only approved compound for reduction of involuntary movements, so called dyskinesia, in fluctuating orally levodopa treated patients. It additionally ameliorates ‘off’-intervals characterized by impaired motor behavior. These beneficial effects result from higher and more continuous brain delivery of amantadine. Future clinical research is warranted on preventive effects of this amantadine capsule combined with enzyme blockers of central monoamine oxidase B and peripheral catechol-O-methyltransferase on motor complications in orally levodopa treated patients, as all these pharmacological principles support the concept of continuous dopamine substitution.

scholarly journals Effective GDNF brain delivery using microspheres—A promising strategy for Parkinson's disease

2009 ◽  
Vol 135 (2) ◽  
pp. 119-126 ◽  
Author(s):  
E. Garbayo ◽  
C.N. Montero-Menei ◽  
E. Ansorena ◽  
J.L. Lanciego ◽  
M.S. Aymerich ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Delivery ◽  
Promising Strategy

Nanoparticles Mediating the Sustained Puerarin Release Facilitate Improved Brain Delivery to Treat Parkinson’s Disease

2019 ◽  
Vol 11 (48) ◽  
pp. 45276-45289 ◽  
Author(s):  
Tongkai Chen ◽  
Wei Liu ◽  
Sha Xiong ◽  
Dongli Li ◽  
Shuhuan Fang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Delivery

Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease

2020 ◽  
Vol 579 ◽  
pp. 119148 ◽  
Author(s):  
Subrat K. Bhattamisra ◽  
Angeline Tzeyung Shak ◽  
Lim Wen Xi ◽  
Nurul Hasyanazifa Safian ◽  
Hira Choudhury ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Chitosan Nanoparticles ◽  
Neuroblastoma Cells ◽  
Brain Delivery
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