Statistically designed nonionic surfactant vesicles for dermal delivery of itraconazole: Characterization and in vivo evaluation using a standardized Tinea pedis infection model

2014 ◽  
Vol 472 (1-2) ◽  
pp. 224-240 ◽  
Author(s):  
Neeraj Kumar ◽  
Shishu Goindi
Keyword(s):  
Nonionic Surfactant ◽  
Tinea Pedis ◽  
Infection Model ◽  
In Vivo Evaluation ◽  
Surfactant Vesicles ◽  
Nonionic Surfactant Vesicles ◽  
Dermal Delivery

scholarly journals Proof of concept studies for siRNA delivery by nonionic surfactant vesicles: in vitro and in vivo evaluation of protein knockdown

2019 ◽  
Vol 29 (3) ◽  
pp. 229-238 ◽  
Author(s):  
Mohammad A. Obeid ◽  
Christine Dufès ◽  
Sukrut Somani ◽  
Alexander B. Mullen ◽  
Rothwelle J. Tate ◽  
...  
Keyword(s):  
Nonionic Surfactant ◽  
Sirna Delivery ◽  
Proof Of Concept ◽  
In Vivo Evaluation ◽  
Surfactant Vesicles ◽  
Nonionic Surfactant Vesicles

scholarly journals Formulation and Characterization of Drug Loaded Nonionic Surfactant Vesicles (Niosomes) for Oral Bioavailability Enhancement

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Sunil Kamboj ◽  
Vipin Saini ◽  
Suman Bala
Keyword(s):  
Nonionic Surfactant ◽  
Oral Bioavailability ◽  
Release Kinetics ◽  
Prolonged Release ◽  
Bioavailability Enhancement ◽  
Surfactant Vesicles ◽  
Nonionic Surfactant Vesicles ◽  
Dicetyl Phosphate

Nonionic surfactant vesicles (niosomes) were formulated with an aim of enhancing the oral bioavailability of tenofovir disoproxil fumarate (TDF), an anti-HIV drug. Niosomes were formulated by conventional thin film hydration technique with different molar ratios of surfactant, cholesterol, and dicetyl phosphate. The formulated niosomes were found spherical in shape, ranging from 2.95 μm to 10.91 μm in size. Vesicles with 1 : 1 : 0.1 ratios of surfactant : cholesterol : dicetyl phosphate with each grade of span were found to have higher entrapment efficiencies, which were further selected forin vitroandin vivostudies. Vesicles formulated with sorbitan monostearate were found to have maximum drug release (99.091%) at the end of 24 hours and followed zero order release kinetics. The results ofin vivostudy revealed that the niosomes significantly enhanced the oral bioavailability of TDF in rats after a dose of 95 mg/kg. The average relative bioavailability of niosomes in relation to plane drug solution was found to be 2.58, indicating more than twofold increase in oral bioavailability of TDF. Significant increase in mean residential time (MRT) was also found, reflecting release retarding efficacy of the vesicles. In conclusion, niosomes could be a promising delivery for TDF with improved oral bioavailability and prolonged release profiles.

Preparation and Characterization of Nonionic Surfactant Vesicles

1996 ◽  
Vol 178 (1) ◽  
pp. 263-273 ◽  
Author(s):  
Don A. van Hal ◽  
Joke A. Bouwstra ◽  
Annemiek van Rensen ◽  
Els Jeremiasse ◽  
Tom de Vringer ◽  
...  
Keyword(s):  
Nonionic Surfactant ◽  
Surfactant Vesicles ◽  
Nonionic Surfactant Vesicles

Microemulsion based gel for topical dermal delivery of pseudolaric acid B: In vitro and in vivo evaluation

2015 ◽  
Vol 493 (1-2) ◽  
pp. 111-120 ◽  
Author(s):  
Tao Wan ◽  
Ting Xu ◽  
Jingtong Pan ◽  
Mengyao Qin ◽  
Wenhui Pan ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Pseudolaric Acid B ◽  
Microemulsion Based Gel ◽  
Dermal Delivery

scholarly journals Doxorubicin Hydrochloride-Loaded Nonionic Surfactant Vesicles to Treat Metastatic and Non-Metastatic Breast Cancer

ACS Omega ◽  
2021 ◽  
Vol 6 (4) ◽  
pp. 2973-2989 ◽  
Author(s):  
Martina Di Francesco ◽  
Christian Celia ◽  
Maria Chiara Cristiano ◽  
Nicola d’Avanzo ◽  
Barbara Ruozi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Nonionic Surfactant ◽  
Metastatic Breast ◽  
Doxorubicin Hydrochloride ◽  
Surfactant Vesicles ◽  
Nonionic Surfactant Vesicles

Immuno-targeting of nonionic surfactant vesicles to inflammation

2007 ◽  
Vol 339 (1-2) ◽  
pp. 222-230 ◽  
Author(s):  
Elizabeth Hood ◽  
Monica Gonzalez ◽  
Anna Plaas ◽  
Joel Strom ◽  
Michael VanAuker
Keyword(s):  
Nonionic Surfactant ◽  
Surfactant Vesicles ◽  
Nonionic Surfactant Vesicles
Sign in / Sign up

Export Citation Format

Share Document