Methotrexate-based ionic liquid as a potent anticancer drug for oral delivery: In vivo pharmacokinetics, biodistribution, and antitumor efficacy

2021 ◽  
Vol 608 ◽  
pp. 121129
Author(s):  
Rahman Md Moshikur ◽  
Md. Korban Ali ◽  
Rie Wakabayashi ◽  
Muhammad Moniruzzaman ◽  
Masahiro Goto
Keyword(s):  
Ionic Liquid ◽  
Anticancer Drug ◽  
Oral Delivery ◽  
Antitumor Efficacy ◽  
In Vivo Pharmacokinetics

Novel bioemulsomes for baicalin oral lymphatic targeting: development, optimization and pharmacokinetics

Nanomedicine ◽  
2021 ◽  
Author(s):  
Samar A Rizk ◽  
Manal A Elsheikh ◽  
Yosra S R Elnaggar ◽  
Ossama Y Abdallah
Keyword(s):  
Oral Delivery ◽  
Physicochemical Characterization ◽  
Lymphatic Transport ◽  
Promising Tool ◽  
Lymphatic Pathway ◽  
In Vivo Pharmacokinetics ◽  
Lymphatic Targeting ◽  
Transport Potential

Aim: The aim of this study was to elaborate on ‘bioemulsomes,' novel biocompatible lipoprotein analogs for effective lymphatic transport of baicalin (BCL). Methods: BCL bioemulsomes were developed and optimized and in vitro physicochemical characterization performed. The bioavailability of BCL bioemulsomes compared with free BCL was investigated using in vivo pharmacokinetics studies. Finally, BCL lymphatic transport was assessed via cycloheximide blockade assay. Results: Optimized BCL-loaded nanoemulsomes showed promising in vitro characteristics that favor lymphatic targeting. In vivo pharmacokinetics showed a significant improvement in bioavailability over free BCL. A significant decrease in BCL emulsome absorption (33%) was exhibited after chemical blockage of the lymphatic pathway, confirming the lymphatic transport potential. Conclusion: Bioemulsomes could be a promising tool for bypassing BCL oral delivery hurdles as well as lymphatic transport, paving the way for potential treatment of lymphoma.

scholarly journals SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy

2016 ◽  
Vol 107 ◽  
pp. 66-78 ◽  
Author(s):  
Charng Choon Wong ◽  
Siang Hui Lim ◽  
Sreenivasa Rao Sagineedu ◽  
Nordin Haji Lajis ◽  
Johnson Stanslas
Keyword(s):  
Anticancer Drug ◽  
Antitumor Efficacy ◽  
Drug Lead

Supramolecular self-assembly and perfected in vitro/vivo property of 5-fluorouracil and ferulic acid on the strength of double optimized strategy: The first 5-fluorouracial-phenolic acid nutraceutical cocrystal with synergistic antitumor efficacy

The Analyst ◽  
2021 ◽  
Author(s):  
Yueming Yu ◽  
Yuan-Yuan Niu ◽  
Ling-Yang Wang ◽  
Yan-Tuan Li ◽  
Zhi-Yong Wu ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Anticancer Drug ◽  
Self Assembly ◽  
Phenolic Acid ◽  
Antitumor Effect ◽  
Antitumor Efficacy

For highlighting the predominance of phenolic acid nutraceutical ferulic acid (FR) in regulating in vivo/vitro performances of anticancer drug 5-fluorouracil (Flu), and strengthening their cooperativity in antitumor effect, thus achieving...

In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations

2019 ◽  
Vol 565 ◽  
pp. 219-226 ◽  
Author(s):  
Md. Raihan Chowdhury ◽  
Rahman Md Moshikur ◽  
Rie Wakabayashi ◽  
Yoshiro Tahara ◽  
Noriho Kamiya ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Antitumor Efficacy

Daptomycin Proliposomes for Oral Delivery: Formulation, Characterization, and In Vivo Pharmacokinetics

2018 ◽  
Vol 19 (4) ◽  
pp. 1802-1809 ◽  
Author(s):  
Javier Rueda Arregui ◽  
Surya Prakasarao Kovvasu ◽  
Guru V. Betageri
Keyword(s):  
Oral Delivery ◽  
In Vivo Pharmacokinetics

Cytotoxicity, NF-κB P65 inhibition, and in vivo antitumor efficacy of sesquiterpene lactones from Piptocoma rufescens

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
Y Ren ◽  
U Muñoz Acuña ◽  
DD Lantvit ◽  
F Jiménez ◽  
R García ◽  
...  
Keyword(s):  
Sesquiterpene Lactones ◽  
Antitumor Efficacy
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