Abstract
Background Familial Mediterranean fever (FMF) is the most seen monogenic
periodic fever syndrome characterised by bouts of fever and serositis. It is
known that subclinical inflammation (SI) can persist in the symptom-free period
and lead to amyloidosis even under colchicine treatment. This study aimed to
evaluate the role of the fibrinogen-to-albumin ratio (FAR) in FMF and its
correlation with SI.
Material and Methods A total of 112 patients with FMF and 78 controls were
enrolled in this retrospective study. Demographic, laboratory and genetic data
were obtained from the hospital records.
Results The FAR values of the FMF cases were significantly higher than the
control group (p<0.001). In the FMF group, the patients with SI had
higher FAR values than those without SI (p<0.001). FAR was positively
correlated with SI (r=0.413, p<0.001). The receiver operating
characteristic curve analysis showed that FAR had a higher area under the curve
value than albumin and fibrinogen.
Conclusion Detecting SI in patients with FMF is crucial in preventing
amyloidosis, the most devastating complication of FMF. FAR is a simple,
inexpensive, easily obtained indicator which can be used for reflecting SI in
FMF.