scholarly journals Monoclonal Antibodies Against the CGRP Receptor Exert Effects at the Level of the Caudal Trigeminal Nucleus and at the Level of the Somatosensory Cortex in Migraine Patients

2021 ◽  
Vol 168 ◽  
pp. S78-S79
Author(s):  
Gianluca Coppola
Keyword(s):  
Monoclonal Antibodies ◽  
Somatosensory Cortex ◽  
Trigeminal Nucleus ◽  
Cgrp Receptor ◽  
Caudal Trigeminal Nucleus

scholarly journals Facial thermal input in the caudal trigeminal nucleus of rats reared at 30 degrees C.

1982 ◽  
Vol 333 (1) ◽  
pp. 545-554 ◽  
Author(s):  
N J Dawson ◽  
R F Hellon ◽  
J G Herington ◽  
A A Young
Keyword(s):  
Trigeminal Nucleus ◽  
Caudal Trigeminal Nucleus

l-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerin-induced nNOS in the rat caudal trigeminal nucleus

2009 ◽  
Vol 57 (4) ◽  
pp. 425-429 ◽  
Author(s):  
Enikő Vámos ◽  
Árpád Párdutz ◽  
Hedvig Varga ◽  
Zsuzsanna Bohár ◽  
János Tajti ◽  
...  
Keyword(s):  
Acid Derivative ◽  
Kynurenic Acid ◽  
The Novel ◽  
Trigeminal Nucleus ◽  
Caudal Trigeminal Nucleus

Sensory processing in a thermal afferent pathway

1985 ◽  
Vol 53 (2) ◽  
pp. 429-434 ◽  
Author(s):  
S. N. Davies ◽  
G. E. Goldsmith ◽  
R. F. Hellon ◽  
D. Mitchell
Keyword(s):  
Sensory Processing ◽  
Receptive Fields ◽  
Second Order ◽  
Dynamic Responses ◽  
Trigeminal Nucleus ◽  
Afferent Pathway ◽  
Afferent Fibers ◽  
Level Of Activity ◽  
Caudal Trigeminal Nucleus ◽  
High Level

Extracellular recordings were made from cold-receptive afferent fibers in the trigeminal ganglion of rats anesthetized with halothane. By applying a standardized series of steady or changing temperatures to the receptive fields, we recorded the static and dynamic responses of the afferents. Comparable recordings were made from neurons in the marginal layer of the caudal trigeminal nucleus onto which the cold fibers synapse. The static and dynamic responses of the afferent fibers were reproduced faithfully by the second-order neurons, but at a much higher level of activity. Ganglionectomy silenced the second-order cells. Their continuous high level of activity appears to depend on the tonic input from the afferent fibers and not on any intrinsic circuits in the medulla.

scholarly journals Therapeutic Monoclonal Antibodies for Migraine

US Neurology ◽  
2015 ◽  
Vol 11 (01) ◽  
pp. 64 ◽  
Author(s):  
Stephen Silberstein ◽  
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Immunoglobulin G ◽  
Preliminary Data ◽  
Episodic Migraine ◽  
Cgrp Receptor ◽  
Calcitonin Gene ◽  
Migraine Pathogenesis ◽  
Igg Isotypes ◽  
Therapeutic Monoclonal Antibodies

Monoclonal antibody (mAb) treatment has revolutionized the approach to many diseases. They comprise immunoglobulin G (IgG) isotypes. Calcitonin gene-related peptide (CGRP) is important in migraine pathogenesis. Four mAbs that target either CGRP or the CGRP receptor are in development for prophylaxis of episodic migraine or chronic migraine. Preliminary data suggest that they are effective.

Modulatory effects of probenecid on the nitroglycerin-induced changes in the rat caudal trigeminal nucleus

2009 ◽  
Vol 621 (1-3) ◽  
pp. 33-37 ◽  
Author(s):  
Eniko Vamos ◽  
Arpad Pardutz ◽  
Annamaria Fejes ◽  
Janos Tajti ◽  
Jozsef Toldi ◽  
...  
Keyword(s):  
Trigeminal Nucleus ◽  
Caudal Trigeminal Nucleus ◽  
Induced Changes
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