Long-term Outcome and Patterns of Failure after Neoadjuvant, Adjuvant and Definitive Chemoradiation in 340 Patients with Locally Advanced Esophageal Cancer

2011 ◽  
Vol 81 (2) ◽  
pp. S308
Author(s):  
F.P. Kong ◽  
L. Sun ◽  
R. Reddy ◽  
M. Schipper ◽  
S. Urba ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Locally Advanced ◽  
Advanced Esophageal Cancer ◽  
Patterns Of Failure ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Definitive Chemoradiation ◽  
Locally Advanced Esophageal Cancer

Patterns of failure following tri-modality therapy for locally advanced esophageal cancer.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 203-203
Author(s):  
Talha Shaikh ◽  
Mark A. Zaki ◽  
Michael M. Dominello ◽  
Elizabeth Handorf ◽  
Andre A. Konski ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Lymph Nodes ◽  
Metastatic Disease ◽  
Locally Advanced ◽  
Post Treatment ◽  
Advanced Esophageal Cancer ◽  
Patterns Of Failure ◽  
Cancer Data ◽  
Locally Advanced Esophageal Cancer

203 Background: Although tri-modality therapy is an acceptable standard of care in patients with locally advanced esophageal cancer, data regarding patterns of failure is lacking. We report bi-institutional patterns of failure experience treating patients using tri-modality therapy. Methods: Following IRB approval, we retrospectively reviewed all pts who underwent chemoradiation followed by esophagectomy at two NCI-designated cancer centers from 2000-2013. Patient and treatment factors were analyzed for failure patterns. First failure sites were categorized as local, regional nodal, or distant. Statistical analysis was performed using Fisher’s exact test and non-parametric Wilcoxon rank-sum test. Results: A total of 132 patients met the inclusion criteria with a median age of 62 (range 36-80) and median follow-up of 28 months (range 4-128). The majority of patients had T3 (82%), N1 (64%), or M0/M1a (92%) disease. At the time of last follow-up there were a total of 6 (4.5%) local, 13 (10%) regional nodal, and 32 (23.5%) distant failures. Local failure was correlated with fewer lymph nodes assessed (p=0.01) and close or positive margins (p<0.01). Regional nodal failure was correlated with fewer lymph nodes assessed (p<0.01) and smaller pre-treatment tumor size (p=0.04). Distant recurrence was correlated with post-treatment nodal stage (p<0.01), peri-neural invasion (p=0.03), negative margins (p=0.02), ulceration (p=0.02), incomplete response (p<0.01), post-treatment PET SUV (p=0.05), 3D-CRT (0.053), metastatic disease at diagnosis (p<0.01) and post-treatment metastatic disease (p<0.01). No other patient, tumor, or treatment factor was correlated with treatment failure. Conclusions: Per our bi-institutional experience, patient, tumor, and treatment factors may predict for failure in patients undergoing tri-modality therapy for locally advanced esophageal cancer. Further data is needed to identify patterns of failure in these patients.

scholarly journals Radical chemoradiotherapy for patients with locally advanced esophageal cancer. Long-term follow up of an ambispective study

2017 ◽  
Vol 28 ◽  
pp. iii29
Author(s):  
Milana Bergamino Sirven ◽  
Ana Ortega Franco ◽  
Gloria Hormigo ◽  
Luisa Aliste ◽  
Isabel Padrol ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Locally Advanced ◽  
Advanced Esophageal Cancer ◽  
Long Term Follow Up ◽  
Locally Advanced Esophageal Cancer

scholarly journals Leukocytosis and neutrophilia predict outcome in locally advanced esophageal cancer treated with definitive chemoradiation

Oncotarget ◽  
2017 ◽  
Vol 8 (7) ◽  
pp. 11579-11588 ◽  
Author(s):  
Antoine Schernberg ◽  
Laurence Moureau-Zabotto ◽  
Eleonor Rivin Del Campo ◽  
Alexandre Escande ◽  
Michel Ducreux ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Locally Advanced ◽  
Advanced Esophageal Cancer ◽  
Definitive Chemoradiation ◽  
Locally Advanced Esophageal Cancer

scholarly journals Long-term survival after esophagectomy with distal pancreatectomy for locally advanced esophageal cancer with pancreatic invasion: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yoshiki Kaneko ◽  
Katsuji Hisakura ◽  
Koichi Ogawa ◽  
Yoshimasa Akashi ◽  
Yusuke Ohara ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Distal Pancreatectomy ◽  
Locally Advanced ◽  
Gastric Mucosal Damage ◽  
Advanced Esophageal Cancer ◽  
Term Survival ◽  
Long Term Survival ◽  
Pancreatic Invasion ◽  
Locally Advanced Esophageal Cancer

Abstract Background The treatment for the locally advanced esophageal cancer invading adjacent organs is controversial. We performed a radical surgery for a patient suffering from lower esophageal cancer with pancreatic invasion, and led to long-term survival. Case presentation A 62-year-old man with dysphagia, was endoscopically diagnosed lower esophageal cancer. Abdominal computed tomography shows that the tumor formed a mass with the solitary metastatic abdominal lymph node, which invaded pancreas body and gastric body. He was diagnosed locally advanced esophageal cancer cStage IIIC. As chemoradiotherapy was difficult because of the high risk of gastric mucosal damage, radical esophagectomy with distal pancreatectomy and reconstruction of gastric conduit were performed. The postoperative course was uneventful and the patient was discharged 16 days after operation. At present, 7 years after surgery, he is still alive with disease-free condition. Conclusion Esophagectomy with distal pancreatectomy may be feasible for locally advanced esophageal cancer with pancreatic invasion in terms of curability and long-term survival.

Prognostic analysis of esophageal squamous cell cancer patients who received neoadjuvant chemoradiotherapy combined with surgery.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 97-97
Author(s):  
Xue Li ◽  
Daxuan Hao ◽  
Yuanyuan Yang ◽  
Yougai Zhang ◽  
Xiaoyuan Wu ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Prognostic Factors ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Locally Advanced ◽  
Neoadjuvant Chemoradiotherapy ◽  
Advanced Esophageal Cancer ◽  
Term Survival ◽  
Locally Advanced Esophageal Cancer

97 Background: The neoadjuvant chemoradiotherapy (nCRT) combined with surgery is hopeful to improve the prognosis of locally advanced esophageal cancer but it remains contentious. Several studies showed that nCRT could significantly improve 5-year OS rate of locally advanced esophageal cancer. However, other clinical trials did not come to the same conclusion. This study retrospectively analyzed the esophageal squamous cell cancer (ESCC) patients who received nCRT combined with surgery in our hospital to investigate the prognostic factors for the patients’ survival. Methods: 96 patients with ESCC who received nCRT combined with surgery in our hospital from January 2007 to December 2014 were retrospectively analyzed. They were diagnosed with preoperation stage T3-4N0-1M0. Among them, 34 cases were in stage IIc and 62 cases were in stage IIIc. Prognostic factors for these patients were analyzed. Results: 26 (27.1%) patients received pathologic complete response (pCR) and 80 (83.3%) patients had downstage. The 1-, 3-, 5-year OS rates of all patients were 91.5%, 63.5%, 55.1%. The 1-, 3-, 5-year OS rates of tumor regression grading(TRG) 1, 2, 3 were 88.9%, 54.1%, 36.5% vs 88.4%, 56.4%, 48.6% vs 95.5%, 90.4%, 90.4%(Р = 0.014). The 1-, 3-, 5-year OS rates of pCR and non-pCR were 95.5%, 90.4%, 90.4% vs 88.6%, 55.6%, 45.4%(Р = 0.004). The 1-, 3-, 5-year OS rates of pathological lymph node negative(ypN-) and positive(ypN+) were 97.3%, 71.1%, 59.8% vs 66.7%, 33.3%, 33.3%(Р = 0.002). The 1-, 3-, 5-year OS rates of downstage and no-downstage were 94.9%, 73.9%, 65.6% vs 75.0%, 18.8%, 12.5% (Р = 0.000). Multivariate analyses identified pathologic lymph nodal status (RR = 2.193, 95%CI:1.018-4.726, Р = 0.045) and downstage category (RR = 3.520, 95%CI:1.638-7.568, Р = 0.001) were significant independent prognostic parameters. Conclusions: The nCRT combined with surgery achieved a high rate of long-term survival without increasing postoperative complications in patients with locally advanced ESCC. TRG was closely associated with patient’s prognosis, especially for patients with pCR. Pathologic lymph nodal status and downstage category were independent influencing factors for long-term survival.

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