Predictors and Survival for Pathologic Tumor Response Grade in Borderline Resectable and Locally Advanced Pancreatic Cancer Treated With Induction Chemotherapy and Neoadjuvant Stereotactic Body Radiation Therapy

2016 ◽  
Vol 96 (2) ◽  
pp. E165
Author(s):  
E.A. Mellon ◽  
S.E. Hoffe ◽  
J.M. Frakes ◽  
T. Strom ◽  
G.M. Springett ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Radiation Therapy ◽  
Induction Chemotherapy ◽  
Stereotactic Body Radiation Therapy ◽  
Tumor Response ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Locally Advanced Pancreatic Cancer ◽  
Borderline Resectable ◽  
Stereotactic Body Radiation

Association of survival with stereotactic body radiation therapy following induction chemotherapy for unresected locally advanced pancreatic cancer

2021 ◽  
pp. 1-8
Author(s):  
Sung Jun Ma ◽  
Lucas M. Serra ◽  
Austin J. Bartl ◽  
Hye Ri Han ◽  
Fatemeh Fekrmandi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Radiation Therapy ◽  
Induction Chemotherapy ◽  
Survival Benefit ◽  
Stereotactic Body Radiation Therapy ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Cox Proportional Hazards ◽  
Locally Advanced Pancreatic Cancer ◽  
Stereotactic Body Radiation

Abstract Aim: Induction chemotherapy (iC) followed by concurrent chemoradiation has been shown to improve overall survival (OS) for locally advanced pancreatic cancer (LAPC). However, the survival benefit of stereotactic body radiation therapy (SBRT) versus conventionally fractionated radiation therapy (CFRT) following iC remains unclear. Materials and methods: The National Cancer Database (NCDB) was queried for primary stage III, cT4N0-1M0 LAPC (2004–15). Kaplan–Meier analysis, Cox proportional hazards method and propensity score matching were used. Results: Among 872 patients, 738 patients underwent CFRT and 134 patients received SBRT. Median follow-up was 24·3 and 22·9 months for the CFRT and SBRT cohorts, respectively. The use of SBRT showed improved survival in both the multivariate analysis (hazards ratio 0·78, p = 0·025) and 120 propensity-matched pairs (median OS 18·1 versus 15·9 months, p = 0·004) compared to the CFRT. Findings: This NCDB analysis suggests survival benefit with the use of SBRT versus CFRT following iC for the LAPC.

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