scholarly journals Final Results of Phase I Study of Prophylactic Nipple-Areola Complex Radiation Therapy after Nipple Sparing Mastectomy and Immediate Reconstruction for Breast Cancer or DCIS Patients

2018 ◽  
Vol 102 (3) ◽  
pp. S226-S227
Author(s):  
C. Takita ◽  
I.M. Reis ◽  
D. Yakoub ◽  
Z. Panthaki ◽  
C. Boneti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Phase I ◽  
Phase I Study ◽  
Immediate Reconstruction ◽  
Nipple Areola Complex ◽  
Areola Complex ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

Experience with nipple-sparing mastectomy after prior whole-breast radiation.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 173-173
Author(s):  
Aimee Marlena Mackey ◽  
Bret Taback ◽  
Preya Ananthakrishnan ◽  
Sheldon M. Feldman
Keyword(s):  
Breast Cancer ◽  
Brca Mutation ◽  
Breast Cancers ◽  
Ipsilateral Breast ◽  
Immediate Reconstruction ◽  
Areola Complex ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing ◽  
Good Cosmesis

173 Background: Nipple-sparing mastectomy (NSM) is being performed more frequently for risk reduction and breast cancer treatment. Prior whole breast irradiation (WBI) has been considered a contraindication to NSM. This study reviews our NSM experience following prior WBI. Methods: We reviewed our prospective mastectomy database from April 2007 to April 2012 for patients undergoing NSM. Ten patients out of a total 169 NSM were identified that underwent NSM following prior WBI. Data collected included incision type, follow-up, complications, cosmesis, and recurrence. Results: Of the ten NSM patients who received prior WBI, 6 had recurrent ipsilateral breast cancer at the lumpectomy site, 3 developed contralateral breast cancers and opted for bilateral NSM, and 1 patient opted for bilateral NSM after finding a BRCA mutation following BCT. Mean patient age was 53. Two patients had comorbities: 1 hyperlipidemia and 1 former smoker. Three of 10 (30%) developed complications, with 2 partial necrosis of nipple-areola complex (NAC) and 1 complete loss of the NAC (Table). No patient required return to the operating room (local resection in the office was performed for the complete NAC loss) and all patients had good final cosmesis. All patients underwent immediate reconstruction: 5 tissue expanders (TE), 2 DIEP and 3 TRAM flaps. Mean follow up is 23 months with no local recurrences to date. Conclusions: This study demonstrates that NSM with immediate reconstruction can be performed in selected patients with prior WBI with an acceptable rate of nipple preservation and good cosmesis. NAC preservation is the ultimate goal in patients undergoing NSM. Current studies are ongoing to identify risk factors that may be associated with nipple necrosis. [Table: see text]

A novel nipple–areola complex involvement predictive index for indicating nipple-sparing mastectomy in breast cancer patients

Breast Cancer ◽  
2019 ◽  
Vol 26 (6) ◽  
pp. 808-816 ◽  
Author(s):  
Hirohito Seki ◽  
Takashi Sakurai ◽  
Shodai Mizuno ◽  
Toshiki Tokuda ◽  
Takuji Kaburagi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Predictive Index ◽  
Nipple Areola Complex ◽  
Areola Complex ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

The Nipple-Sparing Mastectomy: Early Results of a Feasibility Study of a New Application of Perioperative Radiotherapy (Eliot) in the Treatment of Breast Cancer When Mastectomy is Indicated

2003 ◽  
Vol 89 (3) ◽  
pp. 288-291 ◽  
Author(s):  
Jean Yves Petit ◽  
Umberto Veronesi ◽  
Roberto Orecchia ◽  
Piercarlo Rey ◽  
Florence Didier ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Psychological Impact ◽  
Central Area ◽  
Long Term Results ◽  
Nipple Areola Complex ◽  
Areola Complex ◽  
Early Results ◽  
Superficial Skin ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

Background Breast cancer surgery has become less and less mutilating, however a mastectomy is required in the case of multicentric, large tumors or recurrences after conservative treatment. The removal of the nipple areola complex during the mastectomy dramatically increases the feeling of mutilation. To reduce this negative psychological impact, in cancers located outside of the central area of the breast, we propose a new type of nipple-sparing mastectomy associated with intraoperative electron beam radiotherapy (ELIOT) delivered on the region of the areola. The nipple-sparing mastectomy is performed leaving 5 mm of glandular tissue behind the nipple areola complex to preserve its blood supply. The reconstruction is immediately performed with a prosthesis or an autologous flap. Patients and Methods Twenty-five patients were included in the study; two of them had a bilateral nipple-sparing mastectomy. Results Pathological examinations demonstrated the presence of 19 infiltrating carcinomas and 8 ductal carcinoma in situ. Two patients had a superficial skin areolar slough followed by spontaneous healing. One necrosis of the areola occurred due to extensive retroareolar dissection. In the early follow-up, the color of the areola was preserved. All patients except one expressed their satisfaction of having kept their areola. Conclusions These preliminary results are encouraging but they require further studies to evaluate the long-term results, the local recurrence rate and the psychological impact.

Why do women accept to undergo a nipple sparing mastectomy or to reconstruct the nipple areola complex when nipple sparing mastectomy is not possible?

2012 ◽  
Vol 132 (3) ◽  
pp. 1177-1184 ◽  
Author(s):  
F. Didier ◽  
P. Arnaboldi ◽  
S. Gandini ◽  
A. Maldifassi ◽  
A. Goldhirsch ◽  
...  
Keyword(s):  
Nipple Areola Complex ◽  
Areola Complex ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

scholarly journals Nipple-Areola Complex Sensation after Nipple-sparing Mastectomy

2018 ◽  
Vol 6 (4) ◽  
pp. e1716 ◽  
Author(s):  
Prakasit Chirappapha ◽  
Pongsakorn Srichan ◽  
Panuwat Lertsithichai ◽  
Panya Thaweepworadej ◽  
Thongchai Sukarayothin ◽  
...  
Keyword(s):  
Nipple Areola Complex ◽  
Areola Complex ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing
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