scholarly journals Association of Radiation Dose-Fractionation and Immunotherapy Use with Overall Survival in Metastatic Melanoma Patients

2019 ◽  
Vol 105 (1) ◽  
pp. S73
Author(s):  
S.J. Wang ◽  
S.R. Jhawar ◽  
Z. Rivera-Nunez ◽  
J. Byun ◽  
R.R. Parikh ◽  
...  
Keyword(s):  
Overall Survival ◽  
Radiation Dose ◽  
Metastatic Melanoma ◽  
Dose Fractionation ◽  
Melanoma Patients ◽  
Radiation Dose Fractionation

scholarly journals The Association of Radiation Dose-Fractionation and Immunotherapy Use With Overall Survival in Metastatic Melanoma Patients

Cureus ◽  
2020 ◽  
Author(s):  
Shang-Jui Wang ◽  
Sachin R Jhawar ◽  
Zorimar Rivera-Nunez ◽  
Ann W Silk ◽  
John Byun ◽  
...  
Keyword(s):  
Overall Survival ◽  
Radiation Dose ◽  
Metastatic Melanoma ◽  
Dose Fractionation ◽  
Melanoma Patients ◽  
Radiation Dose Fractionation

Serum Immunoregulatory Proteins as Predictors of Overall Survival of Metastatic Melanoma Patients Treated with Ipilimumab

2015 ◽  
Vol 75 (23) ◽  
pp. 5084-5092 ◽  
Author(s):  
Yoshinobu Koguchi ◽  
Helena M. Hoen ◽  
Shelly A. Bambina ◽  
Michael D. Rynning ◽  
Richard K. Fuerstenberg ◽  
...  
Keyword(s):  
Overall Survival ◽  
Metastatic Melanoma ◽  
Melanoma Patients

scholarly journals Alterations in the p53 Pathway and p16INK4a Expression Predict Overall Survival in Metastatic Melanoma Patients Treated with Dacarbazine

2010 ◽  
Vol 130 (10) ◽  
pp. 2514-2516 ◽  
Author(s):  
Christian Busch ◽  
Jürgen Geisler ◽  
Stian Knappskog ◽  
Johan R. Lillehaug ◽  
Per E. Lønning
Keyword(s):  
Overall Survival ◽  
Metastatic Melanoma ◽  
P53 Pathway ◽  
P16ink4a Expression ◽  
Melanoma Patients

scholarly journals Can the plasma PD-1 levels predict the presence and efficiency of tumor-infiltrating lymphocytes in patients with metastatic melanoma?

2019 ◽  
Vol 11 ◽  
pp. 175883591984887 ◽  
Author(s):  
Lorena Incorvaia ◽  
Giuseppe Badalamenti ◽  
Gaetana Rinaldi ◽  
Juan Lucio Iovanna ◽  
Daniel Olive ◽  
...  
Keyword(s):  
Immune Response ◽  
Overall Survival ◽  
Survival Rate ◽  
Metastatic Melanoma ◽  
Braf Mutation ◽  
Primary Melanoma ◽  
Tumor Infiltrating Lymphocytes ◽  
Enzyme Linked Immunosorbent Assay ◽  
Melanoma Patients ◽  
Infiltrating Lymphocytes

Background: The immune response in melanoma patients is locally affected by presence of tumor-infiltrating lymphocytes (TILs), generally divided into brisk, nonbrisk, and absent. Several studies have shown that a greater presence of TILs, especially brisk, in primary melanoma is associated with a better prognosis and higher survival rate. Patients and Methods: We investigated by enzyme-linked immunosorbent assay (ELISA) the correlation between PD-1 levels in plasma and the presence/absence of TILs in 28 patients with metastatic melanoma. Results: Low plasma PD-1 levels were correlated with brisk TILs in primary melanoma, whereas intermediate values correlated with the nonbrisk TILs, and high PD-1 levels with absent TILs. Although the low number of samples did not allow us to obtain a statistically significant correlation between the plasma PD-1 levels and the patients’ overall survival depending on the absence/presence of TILs, the median survival of patients having brisk type TILs was 5 months higher than that of patients with absent and nonbrisk TILs. Conclusions: This work highlights the ability of measuring the plasma PD-1 levels in order to predict the prognosis of patients with untreated metastatic melanoma without a BRAF mutation at the time of diagnosis.

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