Dose-Weighted CT Radiomics Associated with Radiation-Induced Cardiac Toxicity in Women Treated for Localized Breast Cancer

2020 ◽  
Vol 108 (3) ◽  
pp. e776-e777
Author(s):  
J.J. Meshman ◽  
D. Toomeh ◽  
L. Wang ◽  
S. Samuels ◽  
L.M. Freedman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiac Toxicity ◽  
Radiation Induced

Tomorrow's targeted therapies in breast cancer patients: What is the risk for increased radiation-induced cardiac toxicity?

2010 ◽  
Vol 76 (3) ◽  
pp. 186-195 ◽  
Author(s):  
Nicolas Magné ◽  
Cyrus Chargari ◽  
Dhara MacDermed ◽  
Rosa Conforti ◽  
Lionel Védrine ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Targeted Therapies ◽  
Cardiac Toxicity ◽  
Breast Cancer Patients ◽  
Radiation Induced

Complication models to predict radiation-induced cardiac toxicity in patients with breast cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 758-758
Author(s):  
S. K. Das ◽  
A. Baydush ◽  
S. Zhou ◽  
M. Miften ◽  
X. Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiac Toxicity ◽  
Radiation Induced

scholarly journals Evaluation of radiation-induced cardiac toxicity in breast cancer patients treated with Trastuzumab-based chemotherapy

2018 ◽  
Vol 174 (1) ◽  
pp. 179-185 ◽  
Author(s):  
Mohamed Abouegylah ◽  
Lior Z. Braunstein ◽  
Mohamed A. Alm El-Din ◽  
Andrzej Niemierko ◽  
Laura Salama ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cardiac Toxicity ◽  
Breast Cancer Patients ◽  
Radiation Induced

Complication models to predict radiation-induced cardiac toxicity in patients with breast cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 758-758
Author(s):  
S. K. Das ◽  
A. Baydush ◽  
S. Zhou ◽  
M. Miften ◽  
X. Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiac Toxicity ◽  
Radiation Induced

The use of concurrent hormonotherapy and radiotherapy does not deteriorate radiation-induced cardiac toxicity

2016 ◽  
Vol 36 (8) ◽  
pp. 795-801 ◽  
Author(s):  
C Yavas ◽  
G Yavas ◽  
H Toy ◽  
O Ata
Keyword(s):  
Breast Cancer ◽  
Cardiac Fibrosis ◽  
Cardiac Toxicity ◽  
Ovariectomized Rats ◽  
Control Group ◽  
Fibrosis Score ◽  
Limited Data ◽  
Concurrent Administration ◽  
Optimal Sequencing ◽  
Radiation Induced

Postmenopausal patients with breast cancer have two options for adjuvant endocrine therapy, tamoxifen and aromatase inhibitors (AIs) as well as radiotherapy (RT) and chemotherapy. However, there is limited data regarding the optimal sequencing of RT and tamoxifen/AIs. Thus, we aimed to evaluate the effects of tamoxifen and AIs on radiation-induced cardiotoxicity. Eighty ovariectomized rats were divided into eight groups (G). G1 was defined as a control group; G2, G3, G4, and G5 were RT, tamoxifen, anastrozle, and letrozole groups, respectively; G6, G7, and G8 were RT plus tamoxifen, anastrozle, and letrozole groups, respectively. Drugs were started 1 week before RT and continued until the animals were killed 16 weeks after RT. The heart tissues were then dissected and examined with light microscopy to determine endocardial thickness and cardiac fibrosis. The endocardial thickness scores of both RT alone and the tamoxifen groups as well as the cardiac fibrosis score of RT alone were higher than that the control group ( p < 0.05 for all). There was no difference in the endocardial thickness and cardiac fibrosis scores of the RT-only group and the RT plus hormonotherapy groups ( p > 0.05 for all). Concurrent administration of RT and hormonal therapy with either tamoxifen or AIs did not further amplify radiation-induced cardiac toxicity. This issue warrants further study.

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