A clinical pilot study of Resection Process Map: A novel virtual hepatectomy software to visualize the resection process, case series

Despite treating depression with antidepressants, their effectiveness is often insufficient. Comparative effectiveness studies and meta-analyses show the effectiveness of antidepressants; however, they do not provide clear indications as to the choice of a specific antidepressant. The rational choice of antidepressants may be based on matching their mechanisms of action to the symptomatic profiles of depression, reflecting the heterogeneity of symptoms in different patients. The authors presented a series of cases of patients diagnosed with depression in whom at least one previous antidepressant treatment was shown to be ineffective before drug targeted symptom cluster-matching treatment (SCMT). The presented pilot study shows for the first time the effectiveness of SCMT in the different clusters of depressive symptoms. All the described patients obtained recovery from depressive symptoms after introducing drug-targeted SCMT. Once validated in clinical trials, SCMT might become an effective and rational method of selecting an antidepressant according to the individual profile of depressive symptoms, the mechanism of their formation, and the mechanism of drug action. Although the study results are preliminary, SCMT can be a way to personalize treatment, increasing the likelihood of improvement even in patients who meet criteria for treatment-resistant depression.

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A case series evaluation of a modified version of interpersonal psychotherapy (IPT) for the treatment of bulimic eating disorders: A pilot study

European Eating Disorders Review ◽

10.1002/erv.932 ◽

2009 ◽

Vol 17 (4) ◽

pp. 260-268 ◽

Cited By ~ 24

Author(s):

Jon Arcelus ◽

Debbie Whight ◽

Christopher Langham ◽

Jonathan Baggott ◽

Lesley McGrain ◽

...

Keyword(s):

Eating Disorders ◽

Pilot Study ◽

Case Series ◽

Interpersonal Psychotherapy ◽

Series Evaluation

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Evaluation of Absenteeism, Pain, and Disability in Nurses With Persistent Low Back Pain Following Cognitive Functional Therapy: A Case Series Pilot Study With 3-Year Follow-Up

Physical Therapy ◽

10.1093/ptj/pzaa164 ◽

2020 ◽

Author(s):

Wannes Van Hoof ◽

Kieran O’Sullivan ◽

Sabine Verschueren ◽

Peter O’Sullivan ◽

Wim Dankaerts

Keyword(s):

Health Care ◽

Low Back Pain ◽

Pilot Study ◽

Case Series ◽

Health Care Seeking ◽

Low Back ◽

Care Seeking ◽

Functional Therapy ◽

Secondary Outcomes

Abstract Objective Persistent low back pain (PLBP) is a common and costly health problem worldwide. Better strategies to manage it are required. The purpose of this study was to longitudinally evaluate absenteeism, pain, and disability in nurses with PLBP following a cognitive functional therapy (CFT) intervention. Methods In this case series pilot study, 33 eligible nurses with PLBP were recruited. During the baseline phase (phase A; no intervention), outcome measures were collected on 2 occasions 6 months apart (A1 and A2). During phase B, participants received an individualized CFT intervention for 14 weeks. During phase C (no intervention), outcomes were measured immediately after the intervention, as well as 3, 6, 9, 12, and 36 months after the intervention (secondary outcomes only until 12 months). LBP-related work absenteeism, pain intensity (numerical pain rating scale) and disability (Oswestry Disability Index) were the primary outcomes. Health care seeking, a range of psychological and lifestyle variables, and global perceived effect were secondary outcomes. Results Days of absenteeism due to LBP were significantly reduced in the first and second calendar years after the CFT intervention but not the third and fourth. Disability was significantly reduced immediately after (−4.4; 95% CI = −6.5 to −2.2) and at 3 months (−4.3; 95% CI = −6.6 to −2.0), 9 months (−6.0; 95% CI = −8.1 to −3.9), and 12 months (−4.9; 95% CI = −7.0 to −2.8) after the intervention. Pain was significantly reduced immediately after (−1.2; 95% CI = −1.7 to −0.8) and at 3 months (−1.5; 95% CI = −2.0 to −0.9), 9 months (−1.1; 95% CI = −1.9 to −0.3), and 12 months (−0.9; 95% CI = −1.5 to −0.2) after the intervention. Total health care seeking (consults and proportion of participants) was significantly reduced after the intervention. All psychosocial variables, except for 1, demonstrated significant improvements at all follow-up assessments. Conclusions This case series pilot study demonstrated significant reductions in LBP-related absenteeism, pain intensity, disability, health care seeking, and several psychological and lifestyle behaviors until the 1-year follow-up among nurses with PLBP following an individualized CFT intervention. Further evaluation of the efficacy of CFT in high-quality randomized clinical trials among nurses is recommended.

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Safety and feasibility assessment of biodegradable poly (l-lactic acid/ε-caprolactone) membrane for guided bone regeneration: A case series of first-in-human pilot study

Journal of Dental Sciences ◽

10.1016/j.jds.2021.08.015 ◽

2021 ◽

Author(s):

Kinuko Ogata ◽

Seigo Ohba ◽

Yoshinori Sumita ◽

Izumi Ashahina

Keyword(s):

Lactic Acid ◽

Pilot Study ◽

Bone Regeneration ◽

Case Series ◽

Guided Bone Regeneration ◽

Feasibility Assessment ◽

Biodegradable Poly

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Pilot study for home monitoring of cough capacity in amyotrophic lateral sclerosis: A case series

Revista Portuguesa de Pneumologia (English Edition) ◽

10.1016/j.rppnen.2014.06.004 ◽

2014 ◽

Vol 20 (4) ◽

pp. 181-187

Author(s):

M. Paneroni ◽

D. Trainini ◽

J.C. Winck ◽

M. Vitacca

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Pilot Study ◽

Case Series ◽

Home Monitoring ◽

Lateral Sclerosis

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Five-Minute Awake Snoring Test for Determining CPAP Pressures (Five-Minute CPAP Test): A Pilot Study

Sleep Disorders ◽

10.1155/2016/7380874 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Macario Camacho ◽

Chad M. Ruoff ◽

Makoto Kawai ◽

Rahul Modi ◽

Jabri Arbee ◽

...

Keyword(s):

Pilot Study ◽

Positive Relationship ◽

Water Pressure ◽

Negative Relationship ◽

Case Series ◽

Apnea Hypopnea Index ◽

Nasal Cpap ◽

Strong Positive Relationship ◽

Bedside Test ◽

Obstructive Sleep

Objective. To develop a quick, simple, bedside test for determining continuous positive airway pressures (CPAP) for obstructive sleep apnea (OSA) patients.Study Design. Prospective case series at a tertiary medical center.Methods. The Five-Minute Awake Snoring Test for Determining CPAP (Five-Minute CPAP Test) was developed and tested. Patients wear a soft-gel nasal triangle mask while holding a tongue depressor with the wide section (1.75 cm) between the teeth. Fixed pressure nasal CPAP is applied while the patient simulates snoring at 4 centimeters of water pressure. The pressure is incrementally titrated up and then down to determine the lowest pressure at which the patient cannot snore (Quiet Pressure).Results. Overall, thirty-eight patients participated. All could simulate snoring. Correlation coefficients were statistically significant between Quiet Pressures and body mass index (rs=0.60[strong positive relationship],p=0.0088), apnea-hypopnea index (rs=0.49[moderate positive relationship],p=0.039), lowest oxygen saturation (rs=-0.47[moderate negative relationship],p=0.048), and oxygen desaturation index (rs=0.62[strong positive relationship],p=0.0057).Conclusion. This pilot study introduces a new concept, which is the final product of over one year of exploration, development, and testing. Five-Minute CPAP Test is a quick, inexpensive, and safe bedside test based on supine awake simulated snoring with nasal CPAP.

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Faculty Opinions recommendation of A case series evaluation of a modified version of interpersonal psychotherapy (IPT) for the treatment of bulimic eating disorders: a pilot study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1159831.621249 ◽

2009 ◽

Author(s):

Kenneth Bruce

Keyword(s):

Eating Disorders ◽

Pilot Study ◽

Case Series ◽

Interpersonal Psychotherapy ◽

Series Evaluation

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Partial Splenic Artery Embolization for the Treatment of ITP: A Case Series-Pilot Study

Journal of Clinical Interventional Radiology ISVIR ◽

10.1055/s-0038-1676195 ◽

2018 ◽

Vol 03 (01) ◽

pp. 058-061

Author(s):

Mathew Thomas ◽

Manish Yadav ◽

Elsa George

Keyword(s):

Platelet Count ◽

Pilot Study ◽

Splenic Artery ◽

Case Series ◽

Drug Dosage ◽

Artery Embolization ◽

Spontaneous Bleeding ◽

Splenic Artery Embolization ◽

High Doses

AbstractThe purpose of this pilot study was to assess the effectiveness of partial splenic artery embolization (PSE), in the treatment and management of immune thrombocytopenia (ITP). Six patients with ITP who underwent PSE were followed up. The condition was either refractory to medications like steroids, intravenous immunoglobulin, immunosuppressants, or required very high doses of these drugs which could not be tapered down. Five out of six patients did not have good response even after adding immunosuppresants to steroids. The 6 patients who underwent PSE were followed up to 7 to 18 months with an average duration of 3.5 years. A therapeutic effect was defined as a platelet count of > 10,000/cumm (level below which spontaneous bleeding is likely to occur) at the last follow-up date with marked decrease in drug dosage. A good response was seen in all the patients – their doses of drugs could be reduced considerably and all had platelet count well above 10,000 during the last follow up after PSE. None of the patients who underwent embolization had any serious complications.

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