Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells

2013 ◽  
Vol 15 (2) ◽  
pp. 275-281 ◽  
Author(s):  
Ting Bai ◽  
Li-Hua Lian ◽  
Yan-Ling Wu ◽  
Ying Wan ◽  
Ji-Xing Nan
Keyword(s):  
Liver Fibrosis ◽  
Signaling Pathways ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Tlr4 Signaling ◽  
Activated Hepatic Stellate Cells

PDGFRβ-targeted TRAIL specifically induces apoptosis of activated hepatic stellate cells and ameliorates liver fibrosis

APOPTOSIS ◽  
2020 ◽  
Vol 25 (1-2) ◽  
pp. 105-119
Author(s):  
Rui Li ◽  
Zhao Li ◽  
Yanru Feng ◽  
Hao Yang ◽  
Qiuxiao Shi ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Activated Hepatic Stellate Cells

scholarly journals Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Dan Li ◽  
Li He ◽  
Huizhuang Guo ◽  
Hanwei Chen ◽  
Hong Shan
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Activated Hepatic Stellate Cells

Activated hepatic stellate cells participate in liver fibrosis in a patient with transfusional iron overload

1998 ◽  
Vol 33 (5) ◽  
pp. 751-754 ◽  
Author(s):  
Yoshinori Harada ◽  
Masaki Iwai ◽  
Masamichi Kakusui ◽  
Takahiro Mori ◽  
Kazunobu Tada ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Iron Overload ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Activated Hepatic Stellate Cells

287 Senescence of Activated Hepatic Stellate Cells Limits Liver Fibrosis During Alcoholic Liver Injury

2016 ◽  
Vol 150 (4) ◽  
pp. S1025
Author(s):  
Tianhao Zhou ◽  
Heather L. Francis ◽  
Ying Wan ◽  
Julie Venter ◽  
Nan Wu ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Liver Injury ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Alcoholic Liver Injury ◽  
Activated Hepatic Stellate Cells

Interleukin-6 secreted by bipotential murine oval liver stem cells induces apoptosis of activated hepatic stellate cells by activating NF-κB-inducible nitric oxide synthase signaling

2017 ◽  
Vol 95 (2) ◽  
pp. 263-272 ◽  
Author(s):  
Palanivel Gajalakshmi ◽  
Syamantak Majumder ◽  
Cornelia S. Viebahn ◽  
Akila Swaminathan ◽  
George C. Yeoh ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Interleukin 6 ◽  
Hepatic Stellate Cells ◽  
Critical Role ◽  
In Vitro Study ◽  
Stellate Cells ◽  
Causative Factor ◽  
Activated Hepatic Stellate Cells ◽  
Induced Apoptosis

Liver fibrosis is now well recognized as the causative factor for increased mortality from complications associated with liver pathologies. Activated hepatic stellate cells (HSCs) play a critical role in the progression of liver fibrosis. Therefore, targeting these activated HSCs to prevent and (or) treat liver disease is a worthwhile approach to explore. In the present in vitro study, we investigated the use of bipotential murine oval liver cells (BMOL) in regulating the functions of activated HSCs to prevent progression of liver fibrosis. We used a conditioned medium-based approach to study the effect of BMOL cells on activated HSC survival and function. Our data showed that BMOL cells block the contraction of activated HSCs by inducing apoptosis of these cells. We demonstrated that BMOL cells secrete soluble factors, such as interleukin-6 (IL-6), which induced apoptosis of activated HSCs. Using both pharmacological and molecular inhibitor approaches, we further identified that IL-6-mediated activation of NF-κB–iNOS–NO–ROS signaling in activated HSCs plays a critical role in BMOL-cell-mediated apoptosis of activated HSCs. Thus, the present study provides an alternative cell-based therapeutic approach to treat liver fibrosis.

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