Protective effects of ginsenoside Rg1 against lipopolysaccharide/ d -galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway

2018 ◽  
Vol 61 ◽  
pp. 266-276 ◽  
Author(s):  
Chenqing Ning ◽  
Xiaoguang Gao ◽  
Changyuan Wang ◽  
Xiaokui Huo ◽  
Zhihao Liu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Signaling Pathway ◽  
Acute Liver Injury ◽  
Protective Effects ◽  
Ginsenoside Rg1 ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling

2020 ◽  
Vol 11 ◽  
Author(s):  
Qiushi Xu ◽  
Yunhui Fan ◽  
Juan J. Loor ◽  
Yusheng Liang ◽  
Xudong Sun ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
High Mobility ◽  
Hepatoprotective Effect ◽  
Receptor Protein ◽  
Related Factor ◽  
Protective Effects ◽  
Toll Like Receptor 4 ◽  
Sequestosome 1 ◽  
Underlying Mechanisms

Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen- (APAP-) induced hepatotoxicity remains elusive. The objective of this study was to determine the protective effects of CD against APAP-induced acute liver injury (ALI) and the underlying mechanisms. Wild-type or transcription factor nuclear factor erythroid 2-related factor 2- (NFE2L2-) deficient mice were treated with CD (50 or 100 mg/kg, i.p.) or vehicle for 24 h. Subsequently, these mice were challenged with APAP (400 mg/kg, i.p.) for 6 h. Liver and blood samples were collected to evaluate liver injury and protein abundance. Treatment with CD significantly reduced APAP-induced hepatotoxicity. Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling. In addition, CD induced activation of sequestosome 1 (p62) and NFE2L2 signaling and facilitated autophagy. By applying autophagy inhibitor 3-methyladenine (3-MA; 20 mg/kg, i.p.), further mechanistic exploration revealed that NFE2L2 deficiency promoted autophagic activity induced by CD treatment, which was conducive to the hepatoprotective effect of CD against APAP-induced hepatoxicity in NFE2L2−/− mice. Overall, data suggest that CD has hepatoprotective effect against APAP-induced ALI, which might contribute to the activation of NFE2L2 and autophagy.

Benzyl Alcohol Attenuates Acetaminophen-Induced Acute Liver Injury in a Toll-Like Receptor-4 Dependent Pattern in Mice

2014 ◽  
Vol 186 (2) ◽  
pp. 688
Author(s):  
J.A. Luciano ◽  
C. Cai ◽  
B. Kautza ◽  
S. Whelan ◽  
S. Stratimirovic ◽  
...  
Keyword(s):  
Liver Injury ◽  
Benzyl Alcohol ◽  
Acute Liver Injury ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice

Hepatology ◽  
2014 ◽  
Vol 60 (3) ◽  
pp. 990-1002 ◽  
Author(s):  
Changchun Cai ◽  
Hai Huang ◽  
Sean Whelan ◽  
Li Liu ◽  
Benjamin Kautza ◽  
...  
Keyword(s):  
Liver Injury ◽  
Benzyl Alcohol ◽  
Acute Liver Injury ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4
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