Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways

2021 ◽  
Vol 96 ◽  
pp. 107754
Author(s):  
Rajendra Sangaraju ◽  
Sateesh Alavala ◽  
Nasiruddin Nalban ◽  
Mahesh Kumar Jerald ◽  
Ramakrishna Sistla
Keyword(s):  
Signaling Pathways ◽  
Skin Inflammation

scholarly journals Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways

2021 ◽  
Vol 24 (6) ◽  
Author(s):  
Namkyung Kim ◽  
Soyoung Lee ◽  
Jinjoo Kang ◽  
Taeg Kwon ◽  
Dongwoo Khang ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Skin Inflammation ◽  
Inflammatory Signaling

scholarly journals Ghrelin protects against contact dermatitis and psoriasiform skin inflammation by antagonizing TNF-α/NF-κB signaling pathways

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ruize Qu ◽  
Xiaomin Chen ◽  
Jing Hu ◽  
Yufeng Fu ◽  
Jiangfan Peng ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Signaling Pathways ◽  
Skin Inflammation ◽  
Tnf Α

Synergistic inhibitory effects of naproxen in combination with magnolol on TPA-induced skin inflammation in mice

RSC Advances ◽  
2016 ◽  
Vol 6 (44) ◽  
pp. 38092-38099 ◽  
Author(s):  
Yuan Yue ◽  
Wenfeng Liu ◽  
Wei Zhou ◽  
Min Chen ◽  
Boxin Huang ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Skin Inflammation ◽  
Inhibitory Effects ◽  
Pkc Signaling

A combination of naproxen and magnolol effectively inhibited TPA-induced skin inflammationviablocking PI3K/Akt and PI3K/PKC signaling pathways.

Perillyl alcohol inhibits keratinocyte proliferation and attenuates imiquimod-induced psoriasis like skin-inflammation by modulating NF-κB and STAT3 signaling pathways

2022 ◽  
Vol 103 ◽  
pp. 108436
Author(s):  
Sai Sudha Yalamarthi ◽  
Eswara Rao Puppala ◽  
Md. Abubakar ◽  
Pritam Saha ◽  
Veerabhadra Swamy Challa ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Skin Inflammation ◽  
Perillyl Alcohol ◽  
Keratinocyte Proliferation ◽  
Stat3 Signaling

A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

2020 ◽  
Vol 134 (5) ◽  
pp. 473-512 ◽  
Author(s):  
Ryan P. Ceddia ◽  
Sheila Collins
Keyword(s):  
Adipose Tissue ◽  
Energy Expenditure ◽  
Signaling Pathways ◽  
G Protein ◽  
Uncoupling Protein ◽  
Beige Adipocytes ◽  
Nucleotide Regulation ◽  
Ucp1 Expression ◽  
Thermogenic Adipocytes ◽  
G Protein Coupled

Abstract With the ever-increasing burden of obesity and Type 2 diabetes, it is generally acknowledged that there remains a need for developing new therapeutics. One potential mechanism to combat obesity is to raise energy expenditure via increasing the amount of uncoupled respiration from the mitochondria-rich brown and beige adipocytes. With the recent appreciation of thermogenic adipocytes in humans, much effort is being made to elucidate the signaling pathways that regulate the browning of adipose tissue. In this review, we focus on the ligand–receptor signaling pathways that influence the cyclic nucleotides, cAMP and cGMP, in adipocytes. We chose to focus on G-protein–coupled receptor (GPCR), guanylyl cyclase and phosphodiesterase regulation of adipocytes because they are the targets of a large proportion of all currently available therapeutics. Furthermore, there is a large overlap in their signaling pathways, as signaling events that raise cAMP or cGMP generally increase adipocyte lipolysis and cause changes that are commonly referred to as browning: increasing mitochondrial biogenesis, uncoupling protein 1 (UCP1) expression and respiration.

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