Lacrimal gland abscess in a child as a rare manifestation of IgG4-related disease

2018 ◽  
Vol 22 (1) ◽  
pp. 73-75.e1
Author(s):  
Edward L. Raab ◽  
Hamideh S. Moayedpardazi ◽  
Steven M. Naids ◽  
Alan H. Friedman ◽  
Murray A. Meltzer
Keyword(s):  
Lacrimal Gland ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Rare Manifestation

scholarly journals Clinical Manifestations of Orbital Involvement in IgG4-Related Disease: A Retrospective Study of 573 Patients

2021 ◽  
Author(s):  
Linyang Gan ◽  
Xuan Luo ◽  
Yunyun Fei ◽  
Linyi Peng ◽  
Jiaxin Zhou ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Chinese Patients ◽  
Laboratory Findings ◽  
Male Predominance ◽  
Orbital Involvement ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Serum Igg4

Abstract Purpose: To investigate the clinical manifestations of orbital involvement in a large cohort of Chinese patients with IgG4-related disease (IgG4-RD). Methods: A total of 573 patients with IgG4-related disease were included. We described and compared the demographic, clinical, laboratory and histopathologic findings from 314 patients with IgG4-related ophthalmic disease (IgG4-ROD) and 259 with extra-ophthalmic IgG4-RD.Results: Male predominance was found significant in extra-ophthalmic IgG4-RD only. Patients with IgG4-ROD showed younger age at diagnosis and longer duration from onset till diagnosis. In patients with extra-ophthalmic IgG4-RD, the most commonly involved extra-ophthalmic organ was pancreas; while in IgG4-ROD patients, salivary gland was most frequently affected. Multivariate analysis exhibited IgG4-ROD was associated with allergy history, higher serum IgG4/IgG ratio, multiple organs involvement and sialoadenitis. Orbital images were reviewed in 173 (55.1%) IgG4-ROD patients. Fifty-one (29.5%) patients had multiple lesions. Lacrimal gland involvement was detected in 151 (87.3%) patients, followed by extraocular muscles (40, 23.1%), other orbital soft tissue (40, 23.1%) and trigeminal nerve (8, 4.6%). Biopsy was performed from various organs in 390 cases. A dense lymphoplasmacytic infiltration and fibrosis were the main feature in orbital specimens. Storiform fibrosis and obliterative phlebitis were absent in lacrimal gland.Conclusions: Lacrimal gland involvement was the most common orbital manifestation of IgG4-ROD. Patients with IgG4-ROD showed different characteristic in demographic, clinical, laboratory findings compared to patients with extra-ophthalmic IgG4-RD. These features might indicate potential differences in the pathogenesis of these two subgroups of IgG4-RD.

Conjunctival Infiltration in a Child as a Rare Manifestation of IgG4-Related Disease

Cornea ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Susan Ruyu Qi ◽  
Mélanie Hébert ◽  
Eunice You ◽  
Jean-Philippe Proulx-Gauthier ◽  
Marie Eve Légaré
Keyword(s):  
Related Disease ◽  
Igg4 Related Disease ◽  
Rare Manifestation

scholarly journals Applying the consensus statement on the pathology of IgG4-related disease to lacrimal gland lesions

2013 ◽  
Vol 26 (8) ◽  
pp. 1150-1151 ◽  
Author(s):  
Nicholas Andrew ◽  
Daniel Kearney ◽  
Dinesh Selva
Keyword(s):  
Lacrimal Gland ◽  
Consensus Statement ◽  
Related Disease ◽  
Igg4 Related Disease

scholarly journals Paratesticular fibrous pseudotumour: case report of a rare manifestation of IgG4-related disease

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Jeena Raju Kudunthail ◽  
Nikhil Dhimole ◽  
Gurpreet Singh ◽  
Savitri Honakeri
Keyword(s):  
Frozen Section ◽  
Radical Resection ◽  
Tumour Markers ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Benign Pathology ◽  
Frozen Section Analysis ◽  
Serum Igg4 ◽  
Rare Manifestation ◽  
Serum Igg Levels

Abstract Background Paratesticular fibrous pseudotumour is a rare benign growth with unclear pathogenesis and clinical management. It has been linked to Serum IgG4-related disease. This mass can notoriously masquerade around as a malignancy; however, a conservative (testis sparing) approach is sufficient as surgical management. Case presentation We present the case of a 35-year-old gentleman who presented with a slow growing paratesticular mass, raising the suspicion of a malignancy. However, normal tumour markers and benign appearance on imaging modalities compelled us to give trial of local excision with intra-operative frozen section analysis. After confirmation of benign pathology of the mass, the incision was closed. Final histopathology confirmed the diagnosis of benign paratesticular fibrous pseudotumour, and serum IgG levels were noted to be elevated. Conclusion Thus, using tumour markers, radiological imaging and intraoperative frozen section, a potential radical resection can be avoided, testis sparing surgery, employed.

Lacrimal Gland Sparing IgG4-Related Disease in the Orbit

2013 ◽  
Vol 21 (3) ◽  
pp. 220-224 ◽  
Author(s):  
Tanya T. Khan ◽  
Shams K. Halat ◽  
Adham B. al Hariri
Keyword(s):  
Lacrimal Gland ◽  
Related Disease ◽  
Igg4 Related Disease

scholarly journals IgG4-related Disease Presenting as a Pancreatic Mass and Bilateral Lacrimal Gland Swelling

Cureus ◽  
2017 ◽  
Author(s):  
Uroosa Ibrahim ◽  
Amina Saqib ◽  
Nikhil Nalluri ◽  
Muhammad R Raza ◽  
Mark Goldstein
Keyword(s):  
Lacrimal Gland ◽  
Pancreatic Mass ◽  
Related Disease ◽  
Igg4 Related Disease

scholarly journals IgG4-related stomach muscle lesion with a renal pseudotumor and multiple renal rim-like lesions: A rare manifestation of IgG4-related disease

2015 ◽  
Vol 28 (1) ◽  
pp. 188-192 ◽  
Author(s):  
Koichi Inoue ◽  
Takehiko Okubo ◽  
Takashi Kato ◽  
Kazuo Shimamura ◽  
Teruji Sugita ◽  
...  
Keyword(s):  
Stomach Muscle ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Rare Manifestation ◽  
Renal Pseudotumor

scholarly journals Histopathology of salivary glands

Reumatismo ◽  
2018 ◽  
pp. 146-154 ◽  
Author(s):  
F. Carubbi ◽  
A. Alunno ◽  
R. Gerli ◽  
R. Giacomelli
Keyword(s):  
Subcutaneous Fat ◽  
Rectal Mucosa ◽  
Obliterative Phlebitis ◽  
Related Disease ◽  
The Past ◽  
Igg4 Related Disease ◽  
Rare Manifestation ◽  
Storiform Fibrosis ◽  
Consensus Guidance ◽  
Lymphoplasmacytic Infiltration

Salivary gland (SG) biopsy is a technique broadly applied for the diagnosis of primary Sjögren’s syndrome (pSS), lymphoma accompanying SS, sarcoidosis, amyloidosis, and IgG4-related disease The most peculiar feature of pSS on biopsy is focal lymphocytic sialadenitis. In the past, several histological scores have been reported in the literature to describe glandular involvement during pSS. However, the variability among centres in reporting glandular scores is one of the rationales behind the development of standardised consensus guidance. SGs as well as lacrimal glands are involved in up to 50% of patients with IgG4-related disease with 3 histopathological hallmarks such as dense lymphoplasmacytic infiltration, storiform fibrosis and obliterative phlebitis. SGs can be also affected by amyloidosis with MSG biopsy being more sensitive than that of rectal mucosa or subcutaneous fat. SG involvement is a rare manifestation during sarcoidosis, and the presence of non-caseating granulomas needs to be differentiated from granulomas of other etiology. This review article provides an overview of normal and pathological SGs in the context of rheumatic diseases, identifying key elements in the tissue as diagnostic and prognostic biomarkers, useful in the current clinical practice.

Sign in / Sign up

Export Citation Format

Share Document