scholarly journals Optimal target international normalized ratio for patients with mechanical heart valves

2004 ◽  
Vol 44 (5) ◽  
pp. 1142-1143 ◽  
Author(s):  
Johanna J.M. Takkenberg ◽  
John P.A. Puvimanasinghe ◽  
Lex A. van Herwerden
2009 ◽  
Vol 137 (1) ◽  
pp. 91-93 ◽  
Author(s):  
Francesco Dentali ◽  
Nicoletta Riva ◽  
Alessandra Malato ◽  
Giorgia Saccullo ◽  
Sergio Siragusa ◽  
...  

2020 ◽  
Vol 23 (11) ◽  
pp. 1487-1491
Author(s):  
Sultan Abdulwadou ◽  
Nouradden Noman Alja ◽  
Abdulwahab Omer Hussa ◽  
Khalid Mohammed A ◽  
Suliman Gafar Sali

2005 ◽  
Vol 13 (4) ◽  
pp. 341-344 ◽  
Author(s):  
Xin-Min Zhou ◽  
Wei Zhuang ◽  
Jian-Guo Hu ◽  
Jian-Min Li ◽  
Jie-Feng Yu ◽  
...  

The aim of this study was to provide guidelines for optimal anticoagulation in Chinese patients after mechanical heart valve replacement. A Carbomedics valve was implanted in 178 patients between July 2000 and July 2003. During follow-up, 22 bleeding events and 1 thromboembolic complication occurred. The linearized rates of bleeding and thromboembolism were 5.83% and 0.26% per patient-year, respectively. The linearized mortality rate was 0.79% per patient-year. The final mean international normalized ratio (INR) was 1.68 ± 0.38, however there was a significant variation between the early and late periods of follow-up. For Chinese patients with mechanical heart valves, bleeding was the major complication rather than thromboembolism. Low-dose anticoagulation (international normalized ratio 1.4–2.0) could markedly decrease bleeding and effectively prevent thromboembolism. As the INR was most unstable in the first postoperative month, re-examination of patients in this period is critical.


2019 ◽  
Vol 20 (9) ◽  
pp. 659-667 ◽  
Author(s):  
Jeong Yee ◽  
Woorim Kim ◽  
Byung Chul Chang ◽  
Jee Eun Chung ◽  
Kyung Eun Lee ◽  
...  

Aim: This study was designed to identify the possible effects of VEGFA polymorphisms on the occurrence of bleeding complications in patients with mechanical heart valves who have achieved therapeutic international normalized ratio (INR). Materials & methods: 13 SNPs of VEGFA were analyzed. Uni- and multi-variate analyses were conducted to identify associations between polymorphisms and bleeding complications. Results & conclusion: Patients with the CC genotype of rs35410204 had an approximately tenfold higher bleeding complication than those with the T allele. For rs866236, patients who had wild-type homozygotes showed an approximately 2.9-fold higher bleeding complication than C allele carriers. This study demonstrated that bleeding complications during warfarin therapy are associated with VEGFA polymorphisms in patients with mechanical heart valves.


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