scholarly journals TCT-356 Characterizing Non-culprit Coronary Artery Plaques Using Hybrid Near-infrared Spectroscopy and Intravascular Ultrasound: The Rarity of Non-culprit Lesions Having Both a Large Plaque Burden and Large Lipid Burden

2015 ◽  
Vol 66 (15) ◽  
pp. B144
Author(s):  
Mohsin Khan ◽  
Andrew Borgman ◽  
Stacie M. Vanoosterhout ◽  
Abbey Mulder ◽  
Matthew Elmore ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Coronary Artery ◽  
Intravascular Ultrasound ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Plaque Burden ◽  
Large Plaque

scholarly journals Intracoronary near-infrared spectroscopy and the risk of future cardiovascular events

Open Heart ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. e000917 ◽  
Author(s):  
Sofia Karlsson ◽  
Erik Anesäter ◽  
Klara Fransson ◽  
Pontus Andell ◽  
Jonas Persson ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Infrared Spectroscopy ◽  
Coronary Artery ◽  
Near Infrared Spectroscopy ◽  
Cardiovascular Events ◽  
Roc Analysis ◽  
Near Infrared ◽  
Plaque Burden ◽  
Cerebrovascular Events ◽  
Artery Disease

ObjectivesThe objectives of this study were to investigate if findings by intracoronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) are associated with future cardiovascular events and if NIRS can differentiate culprit from non-culprit segments in patients with coronary artery disease.MethodsThe study included 144 patients with coronary artery disease undergoing percutaneous coronary intervention and combined NIRS-IVUS imaging at two Swedish hospitals. The NIRS-derived lipid core burden index (LCBI), the 4 mm segment with maximum LCBI (MaxLCBI4mm) and the IVUS-derived maximum plaque burden (MaxPB) were analysed within the culprit segment and continuous 10 mm non-culprit segments of the index culprit vessels. The association with future major adverse cardiovascular and cerebrovascular events (MACCE), defined as all-cause mortality, acute coronary syndrome requiring revascularisation and cerebrovascular events during follow-up was evaluated using multivariable Cox regressions. A receiver operating characteristic (ROC) analysis was performed to test the ability of NIRS to discriminate culprit against non-culprit segments.ResultsA non-culprit maxLCBI4mm ≥400 (HR: 3.67, 95% CI 1.46 to 9.23, p=0.006) and a non-culprit LCBI ≥ median (HR: 3.08, 95% CI 1.11 to 8.56, p=0.031) were both significantly associated with MACCE, whereas a non-culprit MaxPB ≥70% (HR: 0.61, 95% CI 0.08 to 4.59, p=0.63) was not. The culprit segments had larger lipid cores compared with non-culprit segments (MaxLCBI4mm 425 vs 74, p<0.001), and the ROC analysis showed that NIRS can differentiate culprit against non-culprit segments (c-statistics: 0.85, 95% CI 0.81 to 0.89).ConclusionA maxLCBI4mm ≥400 and LCBI ≥ median, assessed by NIRS in non-culprit segments of a culprit artery, were significantly associated with patient-level MACCE. NIRS furthermore adequately discriminated culprit against non-culprit segments in patients with coronary disease.

In vivo relationship between near-infrared spectroscopy-detected lipid-rich plaques and morphological plaque characteristics by optical coherence tomography and intravascular ultrasound: a multimodality intravascular imaging study

2020 ◽  
Author(s):  
Christian Zanchin ◽  
Yasushi Ueki ◽  
Sylvain Losdat ◽  
Gregor Fahrni ◽  
Joost Daemen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Infrared Spectroscopy ◽  
Intravascular Ultrasound ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Multimodality Imaging ◽  
Plaque Burden ◽  
Optical Coherence ◽  
Coronary Syndrome ◽  
Automated Method

Abstract Aims We assessed morphological features of near-infrared spectroscopy (NIRS)-detected lipid-rich plaques (LRPs) by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS). Methods and results IVUS-NIRS and OCT were performed in the two non-infarct-related arteries (non-IRAs) in patients undergoing percutaneous coronary intervention for treatment of an acute coronary syndrome. A lesion was defined as the 4 mm segment with the maximum amount of lipid core burden index (maxLCBI4mm) of each LRP detected by NIRS. We divided the lesions into three groups based on the maxLCBI4mm value: &lt;250, 250–399, and ≥400. OCT analysis and IVUS analysis were performed blinded for NIRS. We measured fibrous cap thickness (FCT) by using a semi-automated method. A total of 104 patients underwent multimodality imaging of 209 non-IRAs. NIRS detected 299 LRPs. Of those, 41% showed a maxLCBI4mm &lt;250, 39% a maxLCBI4mm 251–399, and 19% a maxLCBI4mm ≥400. LRPs with a maxLCBI4mm ≥400, as compared with LRPs with a maxLCBI4mm 250–399 and &lt;250, were more frequently thin-cap fibroatheroma (TCFA) (42.1% vs. 5.1% and 0.8%; P &lt; 0.001) with a smaller minimum FCT (80 μm vs. 110 μm and 120 μm; P &lt; 0.001); a higher IVUS-derived percent atheroma volume (53% vs. 53% and 44%; P &lt; 0.001) and a higher remodelling index (1.08 vs. 1.02 and 1.01; P &lt; 0.001). MaxLCBI4mm correlated with OCT-derived FCT (r = 0.404; P &lt; 0.001) and was the best predictor for TCFA with an optimal cut-off value of 401 (area under the curve = 0.882; P &lt; 0.001). Conclusion LRPs with increasing maxLCBI4mm exhibit OCT and IVUS features of presumed plaque vulnerability including TCFA morphology, increased plaque burden, and positive remodelling.

scholarly journals Influence of Myocardial Bridge On Atherosclerotic Plaque Distribution and Characteristics Evaluated By Near-Infrared Spectroscopy Intravascular Ultrasound

2021 ◽  
Author(s):  
Kan Saito ◽  
Hideki Kitahara ◽  
Takaaki Mastuoka ◽  
Naoto Mori ◽  
Kazuya Tateishi ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Intravascular Ultrasound ◽  
Near Infrared Spectroscopy ◽  
Atherosclerotic Plaque ◽  
Lipid Content ◽  
Near Infrared ◽  
Proximal Segment ◽  
Plaque Burden ◽  
Myocardial Bridge ◽  
Ivus Imaging

Abstract Purpose This study aims to clarify whether myocardial bridge (MB) could influence atherosclerotic plaque characteristics assessed by using near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) imaging. Methods One hundred and sixteen patients who underwent percutaneous coronary intervention (PCI) using NIRS-IVUS imaging were included. MB was defined as an echo-lucent band surrounding left anterior descending artery (LAD). In MB patients, LAD was divided into 3 segments: proximal, MB, and distal segments. In non-MB patients, corresponding 3 segments were defined based on the average length of the above segments. Segmental maximum plaque burden and lipid content derived from NIRS-IVUS imaging in the section of maximum plaque burden were evaluated in each segment. Lipid content of atherosclerotic plaque was evaluated as lipid core burden index (LCBI) and maxLCBI4mm. LCBI is the fraction of pixels indicating lipid within a region multiplied by 1000, and the maximum LCBI in any 4-mm region was defined as maxLCBI4mm. Results MB was identified in 42 patients. MB was not associated with maximum plaque burden in proximal segment. LCBI and maxLCBI4mm were significantly lower in patients with MB than those without in proximal segment. Multivariable analysis demonstrated both MB and maximum plaque burden in proximal segment to be independent predictors of LCBI in proximal segment. Conclusion Lipid content of atherosclerotic plaque assessed by NIRS-IVUS imaging was significantly smaller in patients with MB than those without. MB could be considered as a predictor of lipid content of atherosclerotic plaque when assessed by NIRS-IVUS imaging.

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