Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients

Kazunari Sugita; Catherine A. Steer; Itziar Martinez-Gonzalez; Can Altunbulakli; Hideaki Morita; Francesc Castro-Giner; Terufumi Kubo; Paulina Wawrzyniak; Beate Rückert; Katsuko Sudo; Susumu Nakae; Kenji Matsumoto; Liam O'Mahony; Mübeccel Akdis; Fumio Takei; Cezmi A. Akdis

doi:10.1016/j.jaci.2017.02.038

Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2017.02.038 ◽

2018 ◽

Vol 141 (1) ◽

pp. 300-310.e11 ◽

Cited By ~ 76

Author(s):

Kazunari Sugita ◽

Catherine A. Steer ◽

Itziar Martinez-Gonzalez ◽

Can Altunbulakli ◽

Hideaki Morita ◽

...

Keyword(s):

Tight Junctions ◽

Innate Lymphoid Cells ◽

Lymphoid Cells ◽

Epithelial Barrier ◽

Bronchial Epithelial ◽

Barrier Integrity ◽

Asthmatic Patients

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Faculty Opinions recommendation of Type 2 innate Lymphoid Cells Disrupt Bronchial Epithelial Barrier Integrity by Targeting Tight Junctions Via IL-13 in Asthma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727493894.793531050 ◽

2017 ◽

Author(s):

Peter Wark

Keyword(s):

Tight Junctions ◽

Innate Lymphoid Cells ◽

Lymphoid Cells ◽

Epithelial Barrier ◽

Bronchial Epithelial ◽

Barrier Integrity

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Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthmatic patients

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2016.03.050 ◽

2017 ◽

Vol 139 (1) ◽

pp. 93-103 ◽

Cited By ~ 69

Author(s):

Paulina Wawrzyniak ◽

Marcin Wawrzyniak ◽

Kerstin Wanke ◽

Milena Sokolowska ◽

Kreso Bendelja ◽

...

Keyword(s):

Histone Deacetylases ◽

Epithelial Barrier ◽

Bronchial Epithelial ◽

Barrier Integrity ◽

Asthmatic Patients ◽

Type 2 Cytokines

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Airway but Not Blood Type 2 Innate Lymphoid Cells (ILC2s) from Asthmatic Patients Are Steroid-Resistant, Which Is Induced By IL7R-Alpha Ligands

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2015.12.1038 ◽

2016 ◽

Vol 137 (2) ◽

pp. AB275

Author(s):

Rafeul Alam ◽

Sucai Liu ◽

Verma Mukesh ◽

Weimin Liu ◽

Magdalena M. Gorska ◽

...

Keyword(s):

Innate Lymphoid Cells ◽

Lymphoid Cells ◽

Blood Type ◽

Steroid Resistant ◽

Asthmatic Patients

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A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis

Zeitschrift für Gastroenterologie ◽

10.1055/s-0035-1567976 ◽

2015 ◽

Vol 53 (12) ◽

Author(s):

K Karimi ◽

K Neumann ◽

J Meiners ◽

R Voetlause ◽

W Dammermann ◽

...

Keyword(s):

Innate Lymphoid Cells ◽

Lymphoid Cells ◽

Immune Mediated

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1886-P: Hepatic Type 2 Innate Lymphoid Cells Suppress Gluconeogenesis via the IL-33/GATA3/IL-13 Axis

Diabetes ◽

10.2337/db19-1886-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 1886-P

Author(s):

MASANORI FUJIMOTO ◽

KOUTARO YOKOTE ◽

TOMOAKI TANAKA

Keyword(s):

Innate Lymphoid Cells ◽

Lymphoid Cells

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Faculty Opinions recommendation of Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13408961.14779065 ◽

2011 ◽

Author(s):

Bruce Levy ◽

Mohib Uddin

Keyword(s):

Innate Lymphoid Cells ◽

Lymphoid Cells

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Faculty Opinions recommendation of Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725957336.793515998 ◽

2016 ◽

Author(s):

Kathryn Wood ◽

Fadi Issa

Keyword(s):

Type I Interferon ◽

Innate Lymphoid Cells ◽

Lymphoid Cells ◽

Type I ◽

Group 2

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Faculty Opinions recommendation of Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725957335.793513867 ◽

2016 ◽

Author(s):

Toshihiro Nakajima ◽

Hidetoshi Fujita

Keyword(s):

Immune Responses ◽

Innate Lymphoid Cells ◽

Innate Immune ◽

Lymphoid Cells ◽

Innate Immune Responses ◽

Group 2

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Faculty Opinions recommendation of Type 2 innate lymphoid cells: A novel biomarker of eosinophilic airway inflammation in patients with mild to moderate asthma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725876024.793511580 ◽

2015 ◽

Author(s):

Harold Nelson

Keyword(s):

Airway Inflammation ◽

Innate Lymphoid Cells ◽

Lymphoid Cells ◽

Moderate Asthma

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Faculty Opinions recommendation of IL-13+ Type 2 Innate Lymphoid Cells Correlate with Asthma Control Status and Treatment Response.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726431092.793522164 ◽

2016 ◽

Author(s):

Peter Wark

Keyword(s):

Treatment Response ◽

Asthma Control ◽

Innate Lymphoid Cells ◽

Lymphoid Cells

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