Safety and Outcomes of 2-step Non-steroidal Anti-inflammatory Drug Provocation Tests in the Outpatient Setting

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Kathleen Buchheit ◽  
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Tanya Laidlaw
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Ilknur Kulhas Celik ◽  
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Laura Levantino ◽  
Cristiana Corrado ◽  
Laura Badina ◽  
Sara Lega ◽  
Egidio Barbi

Non-steroidal anti-inflammatory drugs (NSAIDs) are the main triggers of drug hypersensitivity reactions in children. According to the EAACI latest classification NSAIDs hypersensitivity reactions are differentiated into cross-reactive reactions, with non-immunological mechanisms (based on COX-1 inhibition), and selective reactions, with immunological mechanisms. Paediatric clinical manifestations of NSAID hypersensitivity are typically cutaneous, but sometimes, similarly to anaphylaxis, can involve other systems, especially the respiratory one. Differentiating between NSAID intolerance and NSAID allergy through drug provocation tests is crucial for the patient because the two clinical entities require different management.


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Author(s):  
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Author(s):  
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Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1167-P
Author(s):  
ANIL PAREEK ◽  
RAVI TEJRAJ MEHTA ◽  
SHRUTI DHARMADHIKARI ◽  
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