1H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patients

2005 ◽  
Vol 86 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Paolo Brambilla ◽  
Jeffrey A. Stanley ◽  
Mark A. Nicoletti ◽  
Roberto B. Sassi ◽  
Alan G. Mallinger ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Prefrontal Cortex ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Dorsolateral Prefrontal Cortex ◽  
Resonance Spectroscopy ◽  
1H Magnetic Resonance Spectroscopy ◽  
Dorsolateral Prefrontal

1H Magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patients

2005 ◽  
Vol 138 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Paolo Brambilla ◽  
Jeffrey A. Stanley ◽  
Mark A. Nicoletti ◽  
Roberto B. Sassi ◽  
Alan G. Mallinger ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Mood Disorder ◽  
Dorsolateral Prefrontal Cortex ◽  
Resonance Spectroscopy ◽  
Spectroscopy Study ◽  
1H Magnetic Resonance Spectroscopy ◽  
Magnetic Resonance Spectroscopy Study ◽  
Dorsolateral Prefrontal

31P magnetic resonance spectroscopy (MRS) of the dorsolateral prefrontal cortex in schizophrenics

1997 ◽  
Vol 42 (1) ◽  
pp. 282S
Author(s):  
H.P. Volz ◽  
R. Rzanny ◽  
G. Rößger ◽  
G. Hübner ◽  
W.A. Kaiser ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Dorsolateral Prefrontal Cortex ◽  
Resonance Spectroscopy ◽  
31P Magnetic Resonance Spectroscopy ◽  
Dorsolateral Prefrontal

scholarly journals T17. GLUTAMATE IN DORSOLATERAL PREFRONTAL CORTEX IN PATIENTS WITH SCHIZOPHRENIA: A META-ANALYSIS OF 1-HMRS STUDIES

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S237-S237
Author(s):  
Jakob Kaminski ◽  
Lea Mascarel-Maricic ◽  
Teresa Katthagen ◽  
Andreas Heinz ◽  
Florian Schlagenhauf
Keyword(s):  
Prefrontal Cortex ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Random Effects ◽  
Dorsolateral Prefrontal Cortex ◽  
Meta Analysis ◽  
Functional Markers ◽  
Resonance Spectroscopy ◽  
Random Effects Model ◽  
Dorsolateral Prefrontal

Abstract Background Glutamate especially in frontal cortical areas was proposed to be altered in patients with schizophrenia. In the dorsolateral prefrontal cortex (DLPFC), glutamate levels might serve as functional markers of schizophrenia since this region is involved in working memory function which is impaired in schizophrenia patients. To date, there is no systematic overview on glutamate in dorsolateral prefrontal cortex at high-field intensities. We here meta-analyze magnetic resonance spectroscopy (1-HMRS) studies comprising measurement in dorsolateral prefrontal cortex (DLPFC). Methods Preregistration of the study was performed on September 20th 2019 (osf.io/5uyr6). Predefined literature search on pubmed comprised articles with search terms: (Magnetic Resonance Spectroscopy OR MRS) AND (Glutamate OR Glut* OR GLX) AND (schizophrenia OR psychosis OR schizophren*). We screened for case-control studies comprising glutamate levels as measured by 1-HMRS in DLPFC. Meta-analysis with a fixed and random effects model with inverse variance method, DerSimonian-Laird estimator for tau2 and Cohen’s d were estimated. Results 329 studies were initially screened. 13 Studies were included into quantitative analysis comprising n=436 patients and n=365 controls. The random effects model revealed no difference between patients and controls (d=0.033 [-0.19; 0.26], z=0.29, p=0.77). The test for heterogeneity shows a moderate amount of heterogeneity (tau2=0.096, I2=57.4%). Subsequent sensitivity analysis reveals significant between group effect for medication status (Q=7.94, p=0.0473) i.e. an increased glutamate level in antipsychotic naïve patients (d=0.46 [0.08; 0.84], z=2.37, p=0.018). Discussion We conclude that care has to be taken when evaluating metabolite levels in such a heterogeneous group and interpret that increase cortical glutamate in antipsychotic naïve patients with schizophrenia might be due to possible allostatic mechanisms.

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