Retrospective Cohort
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2022 ◽  
Vol 160 ◽  
pp. 107058
Author(s):  
Jiaming Miao ◽  
Shurong Feng ◽  
Minghao Wang ◽  
Ning Jiang ◽  
Pei Yu ◽  
...  

2022 ◽  
Vol 9 ◽  
pp. 100183
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Lawrence H. Brown ◽  
Remle P. Crowe ◽  
Paul E. Pepe ◽  
Melissa L. Miller ◽  
Brooke L. Watanabe ◽  
...  

2022 ◽  
Vol 28 (3) ◽  
pp. 381-398
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Giuseppe Brisinda ◽  
Maria Michela Chiarello ◽  
Anna Crocco ◽  
Neill James Adams ◽  
Pietro Fransvea ◽  
...  

2022 ◽  
Vol 8 ◽  
pp. 100175
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Yanink Caro-Vega ◽  
Peter F. Rebeiro ◽  
Bryan E. Shepherd ◽  
Pablo F. Belaunzarán-Zamudio ◽  
Brenda Crabtree-Ramirez ◽  
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2022 ◽  
Vol 74 ◽  
pp. 103251
Author(s):  
Ryan M. Chadha ◽  
Margaret R. Paulson ◽  
Francisco R. Avila ◽  
Ricardo A. Torres-Guzman ◽  
Karla Maita ◽  
...  

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Jiacheng He

Abstract Purpose Creatinine to body weight (Cre/BW) ratio is considered the independent risk factor for incident type 2 diabetes mellitus (T2DM), but research on this relationship is limited. The relationship between the Cre/BW ratio and T2DM among Chinse individuals is still ambiguous. This study aimed to evaluate the correlation between the Cre/BW ratio and the risk of T2DM in the Chinese population. Methods This is a retrospective cohort study from a prospectively collected database. We included a total of 200,658 adults free of T2DM at baseline. The risk of incident T2DM according to Cre/BW ratio was estimated using multivariable Cox proportional hazards models, and a two-piece wise linear regression model was developed to find out the threshold effect. Results With a median follow-up of 3.13 ± 0.94 years, a total of 4001 (1.99%) participants developed T2DM. Overall, there was an L-shaped relation of Cre/BW ratio with the risk of incident T2DM (P for non-linearity < 0.001). When the Cre/BW ratio (× 100) was less than 0.86, the risk of T2DM decreased significantly as the Cre/BW ratio increased [0.01 (0.00, 0.10), P < 0.001]. When the Cre/BW ratio (× 100) was between 0.86 and 1.36, the reduction in the risk of developing T2DM was not as significant as before [0.22 (0.12, 0.38), P < 0.001]. In contrast, when the Cre/BW ratio (× 100) was greater than 1.36, the reduction in T2DM incidence became significantly flatter than before [0.73 (0.29,1.8), P = 0.49]. Conclusion There was an L-shaped relation of Cre/BW ratio with incidence of T2DM in general Chinese adults. A negative curvilinear association between Cre/BW ratio and incident T2DM was present, with a saturation effect predicted at 0.86 and 1.36 of Cre/BW ratio (× 100).


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