Predicting Outcomes of Baked Egg and Baked Milk Oral Food Challenges by Using a Ratio of Food-Specific IgE to Total IgE

The pediatrician is faced with evaluating a panoply of skin rashes, a subset of which may be induced by food allergy. Acute urticaria is a common manifestation of an allergic skin response to food, but food is rarely a cause of chronic urticaria. Approximately one third of infants/children with moderate to severe atopic dermatitis have food allergy. Although diagnosis of acute urticaria provoked by a food may be evident from a straightforward history and confirmed by diagnostic tests to detect food-specific IgE antibody, determination of the role of food allergy in patients with atopic dermatitis is more difficult and may require additional diagnostic maneuvers, including elimination diets and oral food challenges. The immunopathologic basis of food-allergic disorders that affect the skin and a rational approach to diagnosis and treatment are discussed. Additional disorders that are caused by or mimic ones caused by food allergy are reviewed.

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Predicting Outcomes of Oral Food Challenges by Using the Allergen-Specific IgE–Total IgE Ratio

The Journal of Allergy and Clinical Immunology In Practice ◽

10.1016/j.jaip.2013.12.006 ◽

2014 ◽

Vol 2 (3) ◽

pp. 300-305 ◽

Cited By ~ 39

Author(s):

Ruchi S. Gupta ◽

Claudia H. Lau ◽

Robert G. Hamilton ◽

Aaron Donnell ◽

Kelly K. Newhall

Keyword(s):

Specific Ige ◽

Total Ige ◽

Food Challenges

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The impact of oral food challenges on food-specific IgE antibody concentrations

Journal of Allergy and Clinical Immunology ◽

10.1016/s0091-6749(03)81290-3 ◽

2003 ◽

Vol 111 (2) ◽

pp. S350-S351

Author(s):

E.J. Vukic ◽

M. Mishoe ◽

S.A. Noone ◽

H.A. Sampson ◽

S.H. Sicherer

Keyword(s):

Specific Ige ◽

Ige Antibody ◽

Food Challenges ◽

Food Specific Ige ◽

The Impact

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Food specific IgE concentrations and risk of positive food challenges

The Indian Journal of Pediatrics ◽

10.1007/bf02752371 ◽

1999 ◽

Vol 66 (1) ◽

pp. 136-136

Keyword(s):

Specific Ige ◽

Food Challenges ◽

Food Specific Ige

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Food allergy

10.1093/med/9780198759928.003.0019 ◽

2018 ◽

Author(s):

John Puntis

Keyword(s):

Food Allergy ◽

Nasal Congestion ◽

Skin Prick Testing ◽

Clinical History ◽

Specific Ige ◽

Cow Milk ◽

Severe Reaction ◽

Detailed Clinical History ◽

Food Challenges ◽

Food Specific Ige

Food allergy is an immune response to food that can be classified as immunoglobulin (Ig)-E and non-IgE mediated. Milk, egg, peanut, tree nuts, and fish are among the most prevalent causes of food allergy. Mild reactions can include itchy rash, watering eyes, and nasal congestion while a severe reaction results in anaphylaxis. A detailed clinical history is essential when making a diagnosis, and skin prick testing and quantitative measurement of food-specific IgE antibodies can be helpful. Cow milk protein allergy causes a plethora of symptoms and frequently resolves spontaneously over the first 2 years of life; diagnosis is based mainly on clinical history. Food challenges have a pivotal role in the diagnosis of food allergy. Introduction of ‘allergic’ foods at 3–6 months alongside continuing breastfeeding may prevent allergy.

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