P2-307: CPHPC depletes serum amyloid P component from the cerebrospinal fluid in Alzheimer's disease

2008 ◽  
Vol 4 ◽  
pp. T462-T462
Author(s):  
Basil H. Ridha ◽  
Martin N. Rossor ◽  
Sebastian J. Crutch ◽  
Geoffrey Keir ◽  
J. Ruth Gallimore ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Serum Amyloid ◽  
Amyloid P Component ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P

Assessment of cerebrospinal fluid levels of serum amyloid P component in patients with Alzheimer's disease

1999 ◽  
Vol 273 (2) ◽  
pp. 137-139 ◽  
Author(s):  
M. Kimura ◽  
T. Asada ◽  
M. Uno ◽  
N. Machida ◽  
K. Kasuya ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Serum Amyloid ◽  
Amyloid P Component ◽  
Cerebrospinal Fluid Levels ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Fluid Levels ◽  
Amyloid P

Involvement of serum amyloid P component and C-reactive protein in the pathogenesis of Alzheimer's disease

2000 ◽  
Vol 21 ◽  
pp. 265
Author(s):  
Robert Veerhuis ◽  
Ingrid Janssen ◽  
Freek L. Van Muiswinkel ◽  
Piet Eikelenboom
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P

Serum Amyloid P Component Scintigraphy in Alzheimer's Disease

1996 ◽  
Vol 90 (s34) ◽  
pp. 18P-18P
Author(s):  
L B Lovat ◽  
A A J O'brien ◽  
S J Armstrong ◽  
S Madhoo ◽  
C J Bulpitt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Serum Amyloid ◽  
Amyloid P Component ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P

scholarly journals Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo

Open Biology ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 150202 ◽  
Author(s):  
Raya Al-Shawi ◽  
Glenys A. Tennent ◽  
David J. Millar ◽  
Angela Richard-Londt ◽  
Sebastian Brandner ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Serum Amyloid ◽  
Amyloid P Component ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid Deposits ◽  
Amyloid P ◽  
Cerebrovascular Amyloid

Human amyloid deposits always contain the normal plasma protein serum amyloid P component (SAP), owing to its avid but reversible binding to all amyloid fibrils, including the amyloid β (Aβ) fibrils in the cerebral parenchyma plaques and cerebrovascular amyloid deposits of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). SAP promotes amyloid fibril formation in vitro , contributes to persistence of amyloid in vivo and is also itself directly toxic to cerebral neurons. We therefore developed (R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC), a drug that removes SAP from the blood, and thereby also from the cerebrospinal fluid (CSF), in patients with AD. Here we report that, after introduction of transgenic human SAP expression in the TASTPM double transgenic mouse model of AD, all the amyloid deposits contained human SAP. Depletion of circulating human SAP by CPHPC administration in these mice removed all detectable human SAP from both the intracerebral and cerebrovascular amyloid. The demonstration that removal of SAP from the blood and CSF also removes it from these amyloid deposits crucially validates the strategy of the forthcoming ‘Depletion of serum amyloid P component in Alzheimer's disease (DESPIAD)’ clinical trial of CPHPC. The results also strongly support clinical testing of CPHPC in patients with CAA.

Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: Similarities with Alzheimer's disease

2007 ◽  
Vol 257 (1-2) ◽  
pp. 88-96 ◽  
Author(s):  
Agueda Rostagno ◽  
Tammaryn Lashley ◽  
Douglas Ng ◽  
Jordana Meyerson ◽  
Hans Braendgaard ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Serum Amyloid ◽  
Amyloid P Component ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P ◽  
Preferential Association

P3-099: Serum Amyloid P component as biomarker in Alzheimer's disease

2008 ◽  
Vol 4 ◽  
pp. T547-T548
Author(s):  
Robert Veerhuis ◽  
Nicolaas A. Verwey ◽  
Alie Schuitemaker ◽  
Wiesje M. Van der Vlier ◽  
Cees Mulder ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Serum Amyloid ◽  
Amyloid P Component ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P

Serum Amyloid P Component as a Biomarker in Mild Cognitive Impairment and Alzheimer’s Disease

2008 ◽  
Vol 26 (6) ◽  
pp. 522-527 ◽  
Author(s):  
Nicolaas A. Verwey ◽  
Alie Schuitemaker ◽  
Wiesje M. van der Flier ◽  
Sandra D. Mulder ◽  
Cees Mulder ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Serum Amyloid ◽  
Amyloid P Component ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P

Serum Amyloid P Component Level in Alzheimer's Disease

1996 ◽  
Vol 7 (5) ◽  
pp. 256-259 ◽  
Author(s):  
Etsuko Nishiyama ◽  
Norihiko Iwamoto ◽  
Michihiro Kimura ◽  
Heii Arai
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Serum Amyloid ◽  
Component Level ◽  
Amyloid P Component ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P
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