Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

2017 ◽  
Vol 13 (6) ◽  
pp. 701-709 ◽  
Author(s):  
Juliane Schelle ◽  
Lisa M. Häsler ◽  
Jens C. Göpfert ◽  
Thomas O. Joos ◽  
Hugo Vanderstichele ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Transgenic Mice ◽  
Bace1 Inhibition

P4-084: Suppression of TAU Increase in Cerebrospinal Fluid of App Transgenic Mice Provides Evidence for Downstream Effect of Bace1 Inhibition

2016 ◽  
Vol 12 ◽  
pp. P1045-P1045
Author(s):  
Stephan A. Kaeser ◽  
Juliane Schelle ◽  
Lisa Haesler ◽  
Jens C. Goepfert ◽  
Thomas O. Joos ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Transgenic Mice ◽  
Bace1 Inhibition

Changes in Amyloid-  and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein

2013 ◽  
Vol 5 (194) ◽  
pp. 194re2-194re2 ◽  
Author(s):  
L. F. Maia ◽  
S. A. Kaeser ◽  
J. Reichwald ◽  
M. Hruscha ◽  
P. Martus ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein

scholarly journals Comparison of Two Different Methods for Measurement of Amyloid-β Peptides in Cerebrospinal Fluid after BACE1 Inhibition in a Dog Model

2013 ◽  
Vol 38 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Herman Borghys ◽  
Tom Jacobs ◽  
Bianca Van Broeck ◽  
Lieve Dillen ◽  
Deborah Dhuyvetter ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Amyloid Β ◽  
Dog Model ◽  
Bace1 Inhibition

P4-265: BACE1 inhibition reduces Abeta production and alters APP processing in non-transgenic mice

2006 ◽  
Vol 2 ◽  
pp. S594-S594
Author(s):  
Gaku Sakaguchi ◽  
Kouhei Nishitomi ◽  
Yuko Horikoshi ◽  
Yoshihiro Nakajima ◽  
Motoko Hosono ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
App Processing ◽  
Abeta Production ◽  
Bace1 Inhibition

P3-359: Central BACE1 inhibition by LY2886721 produces opposing effects on APP processing as reflected by cerebrospinal fluid sAPPalpha and sAPPbeta

2012 ◽  
Vol 8 (4S_Part_16) ◽  
pp. P582-P582 ◽  
Author(s):  
Brian Willis ◽  
Ferenc Martenyi ◽  
Robert Dean ◽  
Stephen Lowe ◽  
Masako Nakano ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
App Processing ◽  
Opposing Effects ◽  
Bace1 Inhibition

O1-06-01: Central BACE1 inhibition by LY2886721 produces opposing effects on APP processing as reflected by cerebrospinal fluid sAPP-alpha and sAPP-beta

2012 ◽  
Vol 8 (4S_Part_3) ◽  
pp. P95-P95 ◽  
Author(s):  
Brian Willis ◽  
Ferenc Martenyi ◽  
Robert Dean ◽  
Stephen Lowe ◽  
Masako Nakano ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
App Processing ◽  
Opposing Effects ◽  
Bace1 Inhibition

scholarly journals β-Amyloid Peptide Variants in Brains and Cerebrospinal Fluid from Amyloid Precursor Protein (APP) Transgenic Mice

2011 ◽  
Vol 286 (39) ◽  
pp. 33747-33758 ◽  
Author(s):  
Heinke Schieb ◽  
Hartmut Kratzin ◽  
Olaf Jahn ◽  
Wiebke Möbius ◽  
Sabine Rabe ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Amyloid-β in the Cerebrospinal Fluid of APP Transgenic Mice Does not Show Prion-like Properties

2015 ◽  
Vol 12 (9) ◽  
pp. 886-891 ◽  
Author(s):  
Zhiva Skachokova ◽  
Frederik Sprenger ◽  
Karin Breu ◽  
Dorothee Abramowski ◽  
Florence Clavaguera ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Transgenic Mice ◽  
Amyloid Β
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