[P1-341]: EVALUATE-AD (ECOLOGICALLY VALID, AMBIENT, LONGITUDINAL AND UNBIASED ASSESSMENT OF TREATMENT EFFICACY IN ALZHEIMER's DISEASE): A PRAGMATIC PROOF-OF-CONCEPT CLINICAL TRIAL

Neil W. Thomas; Nora Mattek; Thomas Riley; Phelps Witter; Christina Reynolds; Johanna Austin; Nicole Sharma; Jeffrey Kaye

doi:10.1016/j.jalz.2017.06.357

[P1-341]: EVALUATE-AD (ECOLOGICALLY VALID, AMBIENT, LONGITUDINAL AND UNBIASED ASSESSMENT OF TREATMENT EFFICACY IN ALZHEIMER's DISEASE): A PRAGMATIC PROOF-OF-CONCEPT CLINICAL TRIAL

Alzheimer s & Dementia ◽

10.1016/j.jalz.2017.06.357 ◽

2017 ◽

Vol 13 (7S_Part_8) ◽

pp. P387-P387

Author(s):

Neil W. Thomas ◽

Nora Mattek ◽

Thomas Riley ◽

Phelps Witter ◽

Christina Reynolds ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Treatment Efficacy ◽

Proof Of Concept

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EVALUATE-AD (ECOLOGICALLY VALID, AMBIENT, LONGITUDINAL AND UNBIASED ASSESSMENT OF TREATMENT EFFICACY IN ALZHEIMER’S DISEASE): A PRAGMATIC PROOF-OF-CONCEPT CLINICAL TRIAL

Alzheimer s & Dementia ◽

10.1016/j.jalz.2017.06.2606 ◽

2017 ◽

Vol 13 (7) ◽

pp. P161

Author(s):

Neil W. Thomas ◽

Nora Mattek ◽

Thomas Riley ◽

Phelps Witter ◽

Christina Reynolds ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Treatment Efficacy ◽

Proof Of Concept

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A Randomized, Double-Blind Phase 2b Proof of Concept Clinical Trial in Early Alzheimer's Disease with BAN2401, an Anti-Aβ Protofibril Antibody

SSRN Electronic Journal ◽

10.2139/ssrn.3672342 ◽

2020 ◽

Author(s):

Chad Swanson ◽

Yong Zhang ◽

Shobha Dhadda ◽

Jinping Wang ◽

June Kaplow ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Proof Of Concept ◽

Double Blind ◽

Early Alzheimer’S Disease

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Lecanemab, an anti-Aβ protofibril antibody: Updated data from a randomized, double-blind phase 2B proof of concept clinical trial and open-label extension in early Alzheimer's disease

Journal of the Neurological Sciences ◽

10.1016/j.jns.2021.117847 ◽

2021 ◽

Vol 429 ◽

pp. 117847

Author(s):

Chad Swanson ◽

Shobha Dhadda ◽

Mark Hodgkinson ◽

David Li ◽

Michio Kanekiyo ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Proof Of Concept ◽

Open Label ◽

Double Blind ◽

Open Label Extension ◽

Early Alzheimer’S Disease

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Application of Clinical Trial Simulation to Compare Proof-of-Concept Study Designs for Drugs with a Slow Onset of Effect; An Example in Alzheimer's Disease

Pharmaceutical Research ◽

10.1007/s11095-006-9048-8 ◽

2006 ◽

Vol 23 (9) ◽

pp. 2050-2059 ◽

Cited By ~ 38

Author(s):

Peter Lockwood ◽

Wayne Ewy ◽

David Hermann ◽

Nick Holford

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Clinical Trial Simulation ◽

Proof Of Concept ◽

Concept Study ◽

Trial Simulation ◽

Study Designs ◽

Slow Onset

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P4-248: Clinical trial simulation to assess the probabilities of technical success for drugs in Alzheimer's disease proof-of-concept studies

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.2273 ◽

2011 ◽

Vol 7 ◽

pp. S793-S793

Author(s):

James Rogers ◽

Brian Corrigan ◽

Terence Fullerton

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Clinical Trial Simulation ◽

Proof Of Concept ◽

Technical Success ◽

Trial Simulation

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A Multi-Center Randomized Proof-of-Concept Clinical Trial Applying [18F]FDG-PET for Evaluation of Metabolic Therapy with Rosiglitazone XR in Mild to Moderate Alzheimer's Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-2010-100939 ◽

2011 ◽

Vol 22 (4) ◽

pp. 1241-1256 ◽

Cited By ~ 50

Author(s):

Sofia Tzimopoulou ◽

Vincent J. Cunningham ◽

Thomas E. Nichols ◽

Graham Searle ◽

Nick P. Bird ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Fdg Pet ◽

Proof Of Concept ◽

Metabolic Therapy ◽

18F Fdg

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P2-027: TARGET ENGAGEMENT IN A PHASE II CLINICAL TRIAL OF AAV2-NGF GENE THERAPY FOR ALZHEIMER'S DISEASE

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.711 ◽

2006 ◽

Vol 14 (7S_Part_12) ◽

pp. P677-P677

Author(s):

Michael J. Castle ◽

Fernando Calvo Baltanas ◽

Imre Kovacs ◽

Alan H. Nagahara ◽

Krystof S. Bankiewicz ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Gene Therapy ◽

Phase Ii ◽

Phase Ii Clinical Trial ◽

Target Engagement ◽

Ngf Gene

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Medical nutrition in Alzheimer's disease: First results and clinical trial

European Journal of Pharmacology ◽

10.1016/j.ejphar.2011.09.213 ◽

2011 ◽

Vol 668 ◽

pp. e8-e9 ◽

Cited By ~ 1

Author(s):

P. Scheltens

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

First Results ◽

Medical Nutrition

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P4-045: Longitudinal ADC changes in Alzheimer's disease in a multi-center clinical trial setting

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.2065 ◽

2011 ◽

Vol 7 ◽

pp. S713-S713

Author(s):

Luc Bracoud ◽

Angelika Caputo ◽

Chahin Pachai ◽

Boubakeur Belaroussi ◽

Ana Graf ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Clinical Trial Setting ◽

Trial Setting

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A clinical trial to validate event‐related potential markers of Alzheimer's disease in outpatient settings

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring ◽

10.1016/j.dadm.2015.08.004 ◽

2015 ◽

Vol 1 (4) ◽

pp. 387-394 ◽

Cited By ~ 7

Author(s):

Marco Cecchi ◽

Dennis K. Moore ◽

Carl H. Sadowsky ◽

Paul R. Solomon ◽

P. Murali Doraiswamy ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Event Related Potential ◽

Outpatient Settings

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