P2-027: TARGET ENGAGEMENT IN A PHASE II CLINICAL TRIAL OF AAV2-NGF GENE THERAPY FOR ALZHEIMER'S DISEASE

Michael J. Castle; Fernando Calvo Baltanas; Imre Kovacs; Alan H. Nagahara; Krystof S. Bankiewicz; David Barba; Mark H. Tuszynski

doi:10.1016/j.jalz.2018.06.711

P2-027: TARGET ENGAGEMENT IN A PHASE II CLINICAL TRIAL OF AAV2-NGF GENE THERAPY FOR ALZHEIMER'S DISEASE

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.711 ◽

2006 ◽

Vol 14 (7S_Part_12) ◽

pp. P677-P677

Author(s):

Michael J. Castle ◽

Fernando Calvo Baltanas ◽

Imre Kovacs ◽

Alan H. Nagahara ◽

Krystof S. Bankiewicz ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Gene Therapy ◽

Phase Ii ◽

Phase Ii Clinical Trial ◽

Target Engagement ◽

Ngf Gene

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P4-016: MCLENA-1: A PHASE II CLINICAL TRIAL FOR THE ASSESSMENT OF SAFETY, TOLERABILITY, AND EFFICACY OF LENALIDOMIDE IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT DUE TO ALZHEIMER'S DISEASE; TRIAL DESIGN AND RATIONALE

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.3675 ◽

2019 ◽

Vol 15 ◽

pp. P1279-P1279

Author(s):

Boris Decourt ◽

Nadia Fulkerson ◽

Alana Burns ◽

Garam Lee ◽

Tessa St Rose ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Phase Ii ◽

Trial Design ◽

Phase Ii Clinical Trial

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Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery

Human Gene Therapy ◽

10.1089/hum.2019.367 ◽

2020 ◽

Vol 31 (7-8) ◽

pp. 415-422 ◽

Cited By ~ 3

Author(s):

Michael J. Castle ◽

Fernando C. Baltanás ◽

Imre Kovacs ◽

Alan H. Nagahara ◽

David Barba ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Gene Therapy ◽

Vector Delivery ◽

Ngf Gene

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PHASE II CLINICAL TRIAL WITH AN AMPA-POSITIVE ALLOSTERIC MODULATOR (S 47445): BASELINE DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF PATIENTS SUFFERING FROM ALZHEIMER’S DISEASE AT MILD TO MODERATE STAGES WITH DEPRESSIVE SYMPTOMS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2017.07.195 ◽

2017 ◽

Vol 13 (7) ◽

pp. P575 ◽

Cited By ~ 1

Author(s):

Jeffrey L. Cummings ◽

Katy Bernard ◽

Sylvie Bretin ◽

Sylvie Gouttefangeas ◽

Maria Pueyo

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Depressive Symptoms ◽

Phase Ii ◽

Clinical Characteristics ◽

Phase Ii Clinical Trial ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Baseline Demographic

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Phase II Clinical Trial of Nicotinamide for the Treatment of Mild to Moderate Alzheimer's Disease

Journal of Geriatric Medicine and Gerontology ◽

10.23937/2469-5858/1510021 ◽

2017 ◽

Vol 3 (1) ◽

Cited By ~ 9

Author(s):

Michael J Phelan

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Phase Ii ◽

Phase Ii Clinical Trial

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MCLENA-1: A Phase II Clinical Trial for the Assessment of Safety, Tolerability, and Efficacy of Lenalidomide in Patients with Mild Cognitive Impairment Due to Alzheimer’s Disease

Open Access Journal of Clinical Trials ◽

10.2147/oajct.s221914 ◽

2020 ◽

Vol Volume 12 ◽

pp. 1-13 ◽

Cited By ~ 1

Author(s):

Boris Decourt ◽

Jeffrey Wilson ◽

Aaron Ritter ◽

Christopher Dardis ◽

Frank DiFilippo ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Phase Ii ◽

Phase Ii Clinical Trial

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Donepezil Improves Gait Performance in Older Adults with Mild Alzheimer's Disease: A Phase II Clinical Trial

Journal of Alzheimer s Disease ◽

10.3233/jad-140759 ◽

2014 ◽

Vol 43 (1) ◽

pp. 193-199 ◽

Cited By ~ 34

Author(s):

Manuel Montero-Odasso ◽

Susan W. Muir-Hunter ◽

Afua Oteng-Amoako ◽

Karen Gopaul ◽

Anam Islam ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Phase Ii ◽

Phase Ii Clinical Trial ◽

Gait Performance

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O4-06-05: PF-04447943: A phase II controlled clinical trial of a selective PDE9A inhbitor in Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.2009 ◽

2011 ◽

Vol 7 ◽

pp. S695-S695 ◽

Cited By ~ 6

Author(s):

Elias Schwam ◽

Rebecca Evans ◽

Timothy Nicholas ◽

Robert Chew ◽

Wendy Davidson ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Phase Ii ◽

Controlled Clinical Trial

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P3-037: CLINICAL TRIAL DESIGN FOR A PHASE II, RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF AMX0035 IN ALZHEIMER'S DISEASE

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.1392 ◽

2006 ◽

Vol 14 (7S_Part_20) ◽

pp. P1078-P1079

Author(s):

Kent L. Leslie ◽

Joshua Cohen ◽

Justin Klee ◽

Victoria Williams ◽

Steven E. Arnold

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Phase Ii ◽

Trial Design ◽

Controlled Trial ◽

Clinical Trial Design

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Analyses of a Phase 1 Clinical Trial of Adeno- associated Virus-Nerve Growth Factor (CERE-110) Gene Therapy in Alzheimer's Disease

Neurosurgery ◽

10.1227/01.neu.0000279944.12903.2c ◽

2007 ◽

Vol 61 (1) ◽

pp. 216-216 ◽

Cited By ~ 4

Author(s):

Roy A.E. Bakay ◽

Zoe Arvanitakis ◽

Mark Tuszynski ◽

Steve Potkin ◽

Ray Bartus ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Gene Therapy ◽

Nerve Growth Factor ◽

Growth Factor ◽

Phase 1 ◽

Adeno Associated Virus ◽

Nerve Growth ◽

Phase 1 Clinical Trial

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30. Phase II Clinical Trial of Gene Therapy for Adenosine Deaminase-Deficient Severe Combined Immune Deficiency (ADA-SCID) Using a γ-Retroviral Vector

Molecular Therapy ◽

10.1016/s1525-0016(16)33634-6 ◽

2015 ◽

Vol 23 ◽

pp. S13-S14 ◽

Cited By ~ 1

Author(s):

Kit L. Shaw ◽

Elizabeth Garabedian ◽

Rob Sokolic ◽

Provaboti Barman ◽

Alejandra Davila ◽

...

Keyword(s):

Immune Deficiency ◽

Clinical Trial ◽

Gene Therapy ◽

Adenosine Deaminase ◽

Phase Ii ◽

Retroviral Vector ◽

Phase Ii Clinical Trial ◽

Severe Combined Immune Deficiency ◽

Combined Immune Deficiency

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