IC-P-004: AMYLOID BURDEN AND CORTICAL ATROPHY IN NON-DEMENTED DOWN SYNDROME

2006 ◽  
Vol 14 (7S_Part_1) ◽  
pp. P16-P16
Author(s):  
Karly Alex Cody ◽  
Tobey J. Betthauser ◽  
Patrick J. Lao ◽  
Annie Cohen ◽  
Dana L. Tudorascu ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cortical Atrophy ◽  
Amyloid Burden

P1-445: AMYLOID BURDEN AND CORTICAL ATROPHY IN NON-DEMENTED DOWN SYNDROME

2006 ◽  
Vol 14 (7S_Part_8) ◽  
pp. P484-P485
Author(s):  
Karly Alex Cody ◽  
Tobey J. Betthauser ◽  
Patrick J. Lao ◽  
Annie Cohen ◽  
Dana L. Tudorascu ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cortical Atrophy ◽  
Amyloid Burden

P1-449: MAPPING AMYLOID DEPOSITION ON CORTICAL ATROPHY IN DOWN SYNDROME: A COMBINED BASELINE AND 2-YEAR LONGITUDINAL ANALYSIS

2006 ◽  
Vol 14 (7S_Part_8) ◽  
pp. P487-P488
Author(s):  
Elijah Mak ◽  
Concepcion Padilla ◽  
Tiina Annus ◽  
Liam Wilson ◽  
Young T. Hong ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Longitudinal Analysis ◽  
Amyloid Deposition ◽  
Cortical Atrophy

scholarly journals Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation

2018 ◽  
Vol 13 (2) ◽  
pp. 345-353 ◽  
Author(s):  
Patrick J. Lao ◽  
Ben L. Handen ◽  
Tobey J. Betthauser ◽  
Karly A. Cody ◽  
Annie D. Cohen ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Amyloid Burden ◽  
Tissue Segmentation ◽  
Down Syndrome Brain

P2-029: Similar beta-amyloid burden in posterior cortical atrophy and Alzheimer's disease

2011 ◽  
Vol 7 ◽  
pp. S317-S317
Author(s):  
Leonardo de Souza ◽  
Fabian Corlier ◽  
Marie Odile Habert ◽  
Olga Uspenskaya ◽  
Renaud Maroy ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Beta Amyloid ◽  
Cortical Atrophy ◽  
Amyloid Burden ◽  
Posterior Cortical Atrophy

IC-P-146: Amyloid burden measured by T1-rho-weighted MRI in Down syndrome

2013 ◽  
Vol 9 ◽  
pp. P87-P87
Author(s):  
Mary Ellen Koran ◽  
Timothy Hohman ◽  
Shashwath Meda ◽  
Jared Cobb ◽  
John Gore ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Amyloid Burden ◽  
T1 Rho

scholarly journals Late onset myoclonic epilepsy in Down syndrome and dementia

2012 ◽  
Vol 6 (3) ◽  
pp. 97-103
Author(s):  
Annapia Verri ◽  
Aglaia Vignoli ◽  
Michele Terzaghi ◽  
Valeria Destefani ◽  
Luigi Nespoli
Keyword(s):  
Down Syndrome ◽  
Low Voltage ◽  
Background Activity ◽  
Late Onset ◽  
Clinical Signs ◽  
Psychometric Evaluation ◽  
Nrem Sleep ◽  
Myoclonic Epilepsy ◽  
Cortical Atrophy ◽  
One Year

Specific forms of epilepsy may be found at various ages in Down Syndrome (DS) and a sharp increase in the incidence of epilepsy with age has been documented. A specific type of myoclonic epilepsy associated with cognitive decline has been reported as “senile myoclonic epilepsy” or “late onset myoclonic epilepsy in DS” (LOMEDS). We report a new case of LOMEDS, documented by clinical and neurophysiological evaluation and psychometric assessment (DSDS and DMR). MF, male, affected by DS, was referred in 2004 at 40 years of age; he had no personal or familial history of epilepsy. Since one year, the patient presented cognitive deterioration, characterized by regression of language abilities, loss of memory, and loss of sphincters control. A brain TC showed mild brainstem and sub-cortical atrophy. In 2006, myoclonic jerks involving upper limbs occurred mainly after awakening. EEG showed a low voltage 8 Hz background activity with diffuse slow activity, intermingled with spikes or polyspikes, persisting during NREM sleep. MF was initially treated with clonazepam and after with topiramate, resulting in partial seizures control. MRI (2008) demonstrated diffuse brain atrophy, associated with marked ventricular enlargement. At the psychometric evaluation, onset of dementia was evident late in 2004, with transition to the middle stage in 2006. Last assessment (2009) showed the clinical signs of a late stage of deterioration, with loss of verbal abilities and autonomous ambulation. Using levetiracetam till 2,000 mg/die, myoclonic jerks decreased but are still present every day after awakening. On the EEG slow and poorly organized background activity with bilateral polyspike-wave discharges was recorded. Therefore, we documented a parallel progression of dementia and myoclonic epilepsy in a DS subject.

scholarly journals White matter microstructure associations to amyloid burden in adults with Down syndrome

2022 ◽  
Vol 33 ◽  
pp. 102908
Author(s):  
Austin M. Bazydlo ◽  
Matthew D. Zammit ◽  
Minjie Wu ◽  
Patrick J. Lao ◽  
Douglas C. Dean ◽  
...  
Keyword(s):  
Down Syndrome ◽  
White Matter ◽  
Amyloid Burden ◽  
White Matter Microstructure

scholarly journals Down syndrome with posterior cortical atrophy

2018 ◽  
pp. bcr-2017-223108 ◽  
Author(s):  
Claire Boutoleau-Bretonnière ◽  
Amandine Pallardy
Keyword(s):  
Down Syndrome ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

scholarly journals Delineating the topography of amyloid-associated cortical atrophy in Down syndrome

2019 ◽  
Vol 80 ◽  
pp. 196-202 ◽  
Author(s):  
Elijah Mak ◽  
Concepcion Padilla ◽  
Tiina Annus ◽  
Liam R. Wilson ◽  
Young T. Hong ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cortical Atrophy

In vivo demonstration of amyloid burden in posterior cortical atrophy: a case series with PET and CSF findings

2011 ◽  
Vol 258 (10) ◽  
pp. 1841-1851 ◽  
Author(s):  
Maïté Formaglio ◽  
Nicolas Costes ◽  
Jérémie Seguin ◽  
Yannick Tholance ◽  
Didier Bars ◽  
...  
Keyword(s):  
Case Series ◽  
Cortical Atrophy ◽  
Amyloid Burden ◽  
Posterior Cortical Atrophy ◽  
Csf Findings
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