Computational investigation of platelet thrombus mechanics and stability in stenotic channels

SummaryExperiments with injury of the abdominal rat skin were carried out to examine the haemostatic system mechanism in vivo after zero to 30 seconds bleeding time. In the bleeding area only a few platelet aggregates could be found with no primary platelet thrombus. After 3.5 second bleeding time the first fibrin strands have been observed at the site of injury. The hypothesis is put forward that there is a very fast reacting haemostatic mechanism which results in the fibrin formation already at 3.5 seconds.

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An Electron Microscopic Study of Platelet Thrombus Formation in the Rabbit with Particular Regard to 5-Hydroxytryptamine Release

Thrombosis and Haemostasis ◽

10.1055/s-0038-1655068 ◽

1967 ◽

Vol 18 (03/04) ◽

pp. 592-604 ◽

Cited By ~ 15

Author(s):

H. R Baumgartner ◽

J. P Tranzer ◽

A Studer

Keyword(s):

Endothelial Cells ◽

Endothelial Cell ◽

Vessel Wall ◽

Thrombus Formation ◽

Endothelial Damage ◽

Electron Microscopic ◽

Rabbit Ear ◽

Basement Lamina ◽

Platelet Thrombus

SummaryElectron microscopic and histologic examination of rabbit ear vein segments 4 and 30 min after slight endothelial damage have yielded the following findings :1. Platelets do not adhere to damaged endothelial cells.2. If the vessel wall is denuded of the whole endothelial cell, platelets adhere to the intimai basement lamina as do endothelial cells.3. The distance between adherent platelets as well as endothelial cells and intimai basement lamina measures 10 to 20 mµ, whereas the distance between aggregated platelets is 30 to 60 mµ.4. 5-hydroxytryptamine (5-HT) is released from platelets during viscous metamorphosis at least in part as 5-HT organelles.It should be noted that the presence of collagen fibers is not necessary for platelet thrombus formation in vivo.

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The Effect of Agents which Modify Platelet Behaviour and of Magnesium Ions on Thrombus Formation In Vivo

Thrombosis and Haemostasis ◽

10.1055/s-0038-1666898 ◽

1979 ◽

Vol 42 (02) ◽

pp. 603-610 ◽

Cited By ~ 59

Author(s):

J H Adams ◽

J R A Mitchell

Keyword(s):

Thrombus Formation ◽

Cerebral Arteries ◽

Magnesium Ions ◽

Body Formation ◽

Inflammatory Agent ◽

Platelet Thrombus ◽

Magnesium Salts ◽

Higher Doses ◽

Do So

SummaryThe ability of potential anti-thrombotic agents to modify platelet-thrombus formation in injured cerebral arteries in the rabbit was tested. Low doses of heparin were without effect, while higher doses produced variable suppression of white body formation but at the expense of bleeding. Aspirin did not inhibit white body formation but another non-steroid anti-inflammatory agent, flurbiprofen was able to do so, as was the anti-gout agent, sulphinpyrazone. Magnesium salts both topically and parenterally, suppressed thrombus formation and increased the concentration of ADP which was required to initiate thrombus production at minor injury sites.

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COMPUTATIONAL INVESTIGATION OF BLADE SAILING PHENOMENON BY FLUID STRUCTURE INTERACTION APPROACH

10.1615/ihmtc-2017.1440 ◽

2018 ◽

Author(s):

Asif Ali ◽

Shrish Shukla ◽

Sidh Nath Singh

Keyword(s):

Fluid Structure Interaction ◽

Computational Investigation ◽

Fluid Structure ◽

Structure Interaction ◽

Interaction Approach ◽

Blade Sailing

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COMPUTATIONAL INVESTIGATION OF DIMPLE EFFECTS ON HEAT TRANSFER AND FRICTION FACTOR IN A LAMILLOY COOLING STRUCTURE

Journal of Enhanced Heat Transfer ◽

10.1615/jenhheattransf.2015013956 ◽

2015 ◽

Vol 22 (2) ◽

pp. 147-175 ◽

Cited By ~ 12

Author(s):

Lei Luo ◽

Chenglong Wang ◽

Lei Wang ◽

Bengt Sunden ◽

Songtao Wang

Keyword(s):

Heat Transfer ◽

Friction Factor ◽

Computational Investigation

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In silico ADME, Bioactivity and Toxicity Parameters Calculation of Some Selected Anti-Tubercular Drugs

International Journal of Pharmaceutical and Phytopharmacological Research ◽

10.24896/eijppr.2016661 ◽

2016 ◽

Vol 6 (6) ◽

pp. 77 ◽

Cited By ~ 1

Author(s):

Shashank Shekhar Mishra ◽

Chandra Shekhar Sharma ◽

Hemendra Pratap Singh ◽

Harshda Pandiya ◽

Neeraj Kumar

Keyword(s):

Antibiotic Resistance ◽

In Silico ◽

Bacillus Calmette Guerin ◽

Computational Investigation ◽

Pharmacological Profile ◽

In Silico Toxicity ◽

Is Development ◽

Potent Drug ◽

Minimal Resistance ◽

Parameters Calculation

Tuberculosis, one of the most frequent infectious diseases, is caused by a mycobacterium tuberculosis bacteria and it infects several hundred million people each year, results in several million deaths annually. Because there is development of antibiotic resistance, the disease becomes incurable. So, in the absence of effective and potent drug with minimal resistance problems, the mortality rate increases annually. In this computational investigation, we performed In-silico ADME, bioactivity and toxicity parameters calculation of some selected anti-tuberculosis agents. To design a new molecule having good pharmacological profile, this study will provide the lead information.Key Words: Tuberculosis (TB), Bacillus Calmette-Guerin vaccine, TPSA, In Silico toxicity

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