Development and validation of a rapid HPLC method for the determination of cefdinir in beagle dog plasma integrated with an automatic on-line solid-phase extraction following protein precipitation in the 96-well plate format

2012 ◽  
Vol 895-896 ◽  
pp. 83-88 ◽  
Author(s):  
Ji Li ◽  
Li Wang ◽  
Zhao Chen ◽  
Rui Xie ◽  
You Li ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Solid Phase ◽  
Hplc Method ◽  
Protein Precipitation ◽  
Phase Extraction ◽  
Beagle Dog ◽  
Dog Plasma ◽  
On Line ◽  
Development And Validation

Determination of danshensu concentration in beagle dog plasma by on-line solid phase extraction-HPLC method

2011 ◽  
Vol 11 (3) ◽  
pp. 203-206
Author(s):  
Li WANG ◽  
XiaoRu CUI ◽  
YingHui DOU ◽  
Jun WEN ◽  
TaiJun HANG ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Solid Phase ◽  
Hplc Method ◽  
Phase Extraction ◽  
Beagle Dog ◽  
Dog Plasma ◽  
On Line

scholarly journals Development and validation of a bioanalytical LC-UV method with solid-phase extraction for determination of valproic acid in saliva

2012 ◽  
Vol 62 (2) ◽  
pp. 211-220 ◽  
Author(s):  
Jasmina Tonic-Ribarska ◽  
Arlinda Haxhiu ◽  
Zoran Sterjev ◽  
Gordana Kiteva ◽  
Ljubica Suturkova ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Human Saliva ◽  
Hplc Method ◽  
Therapeutic Monitoring ◽  
Phase Extraction ◽  
Free Drug Concentration ◽  
Development And Validation

Development and validation of a bioanalytical LC-UV method with solid-phase extraction for determination of valproic acid in saliva A bioanalytical HPLC method with UV detection for the determination of the antiepileptic drug valproic acid in human saliva has been developed and validated. Saliva represents an alternative matrix for therapeutic monitoring of antiepileptic drugs due to the increasing interest in free drug concentration. The proposed method involved solid-phase extraction for sample preparation and yielded very good mean recoveries of 99.4 % and 97.9 % for valproic acid and IS, respectively. The calibration function for valproic acid was linear over the concentration range of 1.0-50.0 μg mL-1 (R2 = 0.9989). Within-run and between-run precision and accuracy were studied at four concentrations and RSDs were less than 7.3 and 2.2 %, while accuracy values were higher than 96.8 and 97.5 %, respectively. The described method provides sensitivity, linearity, precision, accuracy and is suitable for analyses of valproic acid in saliva samples.

Development and validation of an HPLC method for determination of amphotericin B in plasma and sputum involving solid phase extraction

1997 ◽  
Vol 46 (11-12) ◽  
pp. 641-646 ◽  
Author(s):  
M. A. Campanero ◽  
A. M. Zamarreño ◽  
M. Diaz ◽  
M. C. Dios-Vieitez ◽  
J. R. Azanza
Keyword(s):  
Solid Phase Extraction ◽  
Amphotericin B ◽  
Solid Phase ◽  
Hplc Method ◽  
Phase Extraction ◽  
Development And Validation

Development and validation of an HPLC-method for determination of free and bound phenolic acids in cereals after solid-phase extraction

2012 ◽  
Vol 134 (3) ◽  
pp. 1624-1632 ◽  
Author(s):  
Maria N. Irakli ◽  
Victoria F. Samanidou ◽  
Costas G. Biliaderis ◽  
Ioannis N. Papadoyannis
Keyword(s):  
Solid Phase Extraction ◽  
Phenolic Acids ◽  
Solid Phase ◽  
Hplc Method ◽  
Phase Extraction ◽  
Development And Validation
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