The pivotal role of oxygen in establishing superlow friction by inducing the in situ formation of a robust MoS2 transfer film

2021 ◽  
Vol 594 ◽  
pp. 824-835
Author(s):  
Guomin Yu ◽  
Qingyi Qian ◽  
Donghao Li ◽  
Zhenxi Zhang ◽  
Kexin Ren ◽  
...  
Keyword(s):  
Transfer Film ◽  
Pivotal Role ◽  
In Situ Formation

scholarly journals Spatial genomics maps the structure, character and evolution of cancer clones

2021 ◽  
Author(s):  
Artem Lomakin ◽  
Jessica Svedlund ◽  
Carina Strell ◽  
Milana Gataric ◽  
Artem Shmatko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Data Integration ◽  
Cancer Progression ◽  
Lineage Tracing ◽  
Breast Cancer Progression ◽  
Pivotal Role ◽  
Universal Feature

Subclonality is a universal feature of cancers yet how clones grow, are spatially organised, differ phenotypically or influence clinical outcome is unclear. To address this, we developed base specific in situ sequencing (BaSISS). In fixed tissues, transcripts harbouring clone-defining mutations are detected, converted into quantitative clone maps and characterised through multi-layered data integration. Applied to 8 samples from key stages of breast cancer progression BaSISS localised 1.42 million genotype informative transcripts across 4.9cm2 of tissue. Microscopic clonal topographies are shaped by resident tissue architectures. Distinct transcriptional, histological and immunological features distinguish coexistent genetic clones. Spatial lineage tracing temporally orders clone features associated with the emergence of aggressive clinical traits. These results highlight the pivotal role of spatial genomics in deciphering the mechanisms underlying cancer progression.

Diastereoselectivity in asymmetric allylations: The role of vicinal chirality in the allyl nucleophile for SE2′ reactions with aldehydes

2004 ◽  
Vol 82 (2) ◽  
pp. 120-130 ◽  
Author(s):  
David R Williams ◽  
Kevin G Meyer ◽  
Khalida Shamim ◽  
Samarjit Patnaik
Keyword(s):  
Chiral Auxiliary ◽  
Asymmetric Allylation ◽  
Relative Significance ◽  
Homoallylic Alcohols ◽  
In Situ Formation

A series of nonracemic homoallylic alcohols have been prepared by asymmetric allylation using the (R,R)- and (S,S)-1,2-diamino-1,2-diphenylethane bis-sulfonamide controller ligands for in situ formation of chiral B-allyl-1,3,2-diazaborolidines. Diastereofacial selectivity is influenced by adjacent stereochemistry incorporated into the allyl moiety at C-2, in addition to the expected role of the chiral auxiliary. Additional asymmetry in the aldehyde reactant introduces threefold stereodifferentiation. A model is developed to identify reinforcing stereochemical relationships, and examples have ascertained the relative significance of these factors. The methodology supports the construction of complex homoallylic alcohols in a highly convergent fashion.Key words: asymmetric allylation, diastereofacial selectivity, 1,4-stereocontrol, homoallylic alcohols.

Role of grafted chains for the in situ formation of Ag nanoparticles within poly(epichlorohydrin)-g-polymethacrylate films

2009 ◽  
Vol 9 (4) ◽  
pp. e298-e300
Author(s):  
Jung Tae Park ◽  
Kyung Ju Lee ◽  
Jong Kwan Koh ◽  
Jong Hak Kim ◽  
Ki Bong Lee
Keyword(s):  
Ag Nanoparticles ◽  
In Situ Formation

scholarly journals Planetesimal fragmentation and giant planet formation: the role of planet migration

2014 ◽  
Vol 9 (S310) ◽  
pp. 204-207
Author(s):  
O. M. Guilera ◽  
D. Swoboda ◽  
Y. Alibert ◽  
G. C. de Elía ◽  
P. J. Santamaría ◽  
...  
Keyword(s):  
Giant Planet ◽  
Giant Planets ◽  
New Work ◽  
The Standard Model ◽  
Planet Migration ◽  
In Situ Formation ◽  
Core Accretion ◽  
Planet Accretion

AbstractIn the standard model of core accretion, the cores of the giant planets form by the accretion of planetesimals. In this scenario, the evolution of the planetesimal population plays an important role in the formation of massive cores. Recently, we studied the role of planetesimal fragmentation in the in situ formation of a giant planet. However, the exchange of angular momentum between the planet and the gaseous disk causes the migration of the planet in the disk. In this new work, we incorporate the migration of the planet and study the role of planet migration in the formation of a massive core when the population of planetesimals evolves by planet accretion, migration, and fragmentation.

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