Mucinous intestinal type adenocarcinoma of the sinonasal tract secondary to passive wood dust inhalation: case report

AbstractA sporadic case of the intestinal-type sinonasal adenocarcinoma is described. The patient was a comparatively young 33-year-old woman employed as a senior biochemical scientific technologist for several years. The light microscopical pattern was that of a papillary-tubular adenocarcinoma with areas of more solid mucinous elements in the deeper parts of the neoplasm. The neoplasm had invaded the nasal septum and reached the left orbit invading the left ethmoidal sinus. The glands were lined by columnar cells with elongated spindle-shaped nuclei and the cells expressed cytokeratin, carcinoembryonic antigen (CEA), Chromogranin A, gastrin and serotonin but not neurone-specific enolase (NSE) nor synaptophysin. Neurosecretory granules were present. There was no history of wood dust inhalation and her exposure to chemicals is of some interest but had probably little or no role in the causation of this neoplasm.

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Primary intestinal-type adenocarcinoma of the oral tongue: Case report and review of histologic origin and oncologic management

Head & Neck ◽

10.1002/hed.25203 ◽

2018 ◽

Vol 40 (7) ◽

pp. E68-E72 ◽

Cited By ~ 2

Author(s):

Jenna Berg ◽

Rodolfo E. Manosalva ◽

Andrew Coughlin ◽

Yungpo Bernard Su ◽

Tien-Shew Huang ◽

...

Keyword(s):

Case Report ◽

Intestinal Type ◽

Oral Tongue ◽

Intestinal Type Adenocarcinoma

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Primary Intestinal-Type Adenocarcinoma of Tongue: A Case Report with Immunohistochemical and Molecular Profiles and Review of the Literature

Head and Neck Pathology ◽

10.1007/s12105-016-0759-9 ◽

2016 ◽

Vol 11 (2) ◽

pp. 186-191 ◽

Cited By ~ 5

Author(s):

Siavash Rahimi ◽

Iolia Akaev ◽

Costa Repanos ◽

Peter A. Brennan ◽

Jean Daniel Dubois

Keyword(s):

Case Report ◽

Intestinal Type ◽

Review Of The Literature ◽

Intestinal Type Adenocarcinoma ◽

Molecular Profiles

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Composite intestinal-type adenocarcinoma and small cell carcinoma of sinonasal tract

Journal of Clinical Pathology ◽

10.1136/jcp.2009.065433 ◽

2009 ◽

Vol 62 (7) ◽

pp. 634-637 ◽

Cited By ~ 9

Author(s):

R Jain ◽

V Gramigna ◽

R Sanchez-Marull ◽

B Perez-Ordonez

Keyword(s):

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Small Cell ◽

Sinonasal Tract ◽

Intestinal Type ◽

Intestinal Type Adenocarcinoma

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Female urethral intestinal type adenocarcinoma: Case report and review of literature

Urological Science ◽

10.1016/j.urols.2016.05.234 ◽

2016 ◽

Vol 27 (2) ◽

pp. S63

Author(s):

Chu-Hsuan Hung ◽

Kuo-Chiang Chen

Keyword(s):

Case Report ◽

Intestinal Type ◽

Review Of Literature ◽

Intestinal Type Adenocarcinoma

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Occurrence of Sinonasal Intestinal-Type Adenocarcinoma and Non-Intestinal-Type Adenocarcinoma in Two Countries with Different Patterns of Wood Dust Exposure

Cancers ◽

10.3390/cancers13205245 ◽

2021 ◽

Vol 13 (20) ◽

pp. 5245

Author(s):

Ilmo Leivo ◽

Reetta Holmila ◽

Danièle Luce ◽

Torben Steiniche ◽

Michael Dictor ◽

...

Keyword(s):

Systematic Study ◽

Diagnostic Workup ◽

Intestinal Type ◽

Dust Exposure ◽

Wood Dust ◽

Systematic Comparison ◽

Sinonasal Adenocarcinoma ◽

Intestinal Type Adenocarcinoma ◽

Tumor Types

Sinonasal intestinal-type adenocarcinoma is strongly associated with hardwood dust exposure. Non-intestinal-type adenocarcinoma is a rarer and less well-known subtype considered not to be related with wood dust exposure. We determined the relative numbers of these two tumor types in 56 sinonasal adenocarcinoma patients in France and Finland, relating them with carefully assessed wood dust exposure histories. Diagnostic workup including immunohistochemistry for the intestinal markers CDX2 and CK20 indicated that the proportions of the two tumors differed significantly between France and Finland. In Finnish samples non-intestinal adenocarcinomas were more common than intestinal-type adenocarcinomas (12 non-intestinal vs. nine intestinal), while in the French samples the reverse was true (six non-intestinal vs. 29 intestinal). Such remarkably dissimilar occurrence of these tumors in France and Finland presumably reflects different pathogenetic circumstances in the two countries, and perhaps their different patterns of wood dust exposure. In France the main source of wood dust is from hardwoods. In Finland it is derived from softwoods. This is the first systematic comparison of the occurrence of intestinal-type adenocarcinoma and non-intestinal-type adenocarcinoma in two countries with different wood usage. It appears to be the first systematic study on differences in wood dust exposure between intestinal-type adenocarcinoma and non-intestinal-type adenocarcinoma.

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