Intestinal-type sinonasal adenocarcinoma: a sporadic case

1996 ◽  
Vol 110 (8) ◽  
pp. 805-810 ◽  
Author(s):  
Andrej Böör ◽  
Ivan Jurkovič ◽  
Katarína Dudríková ◽  
Vojtech Kavečanský ◽  
Imrich Friedmann
Keyword(s):  
Nasal Septum ◽  
Chromogranin A ◽  
Sporadic Case ◽  
Intestinal Type ◽  
Wood Dust ◽  
Tubular Adenocarcinoma ◽  
Dust Inhalation ◽  
Sinonasal Adenocarcinoma ◽  
History Of ◽  
Columnar Cells

AbstractA sporadic case of the intestinal-type sinonasal adenocarcinoma is described. The patient was a comparatively young 33-year-old woman employed as a senior biochemical scientific technologist for several years. The light microscopical pattern was that of a papillary-tubular adenocarcinoma with areas of more solid mucinous elements in the deeper parts of the neoplasm. The neoplasm had invaded the nasal septum and reached the left orbit invading the left ethmoidal sinus. The glands were lined by columnar cells with elongated spindle-shaped nuclei and the cells expressed cytokeratin, carcinoembryonic antigen (CEA), Chromogranin A, gastrin and serotonin but not neurone-specific enolase (NSE) nor synaptophysin. Neurosecretory granules were present. There was no history of wood dust inhalation and her exposure to chemicals is of some interest but had probably little or no role in the causation of this neoplasm.

scholarly journals Benign Lesions in Mucosa Adjacent to Intestinal-Type Sinonasal Adenocarcinoma

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Blanca Vivanco ◽  
José Luis Llorente ◽  
Jhudit Perez-Escuredo ◽  
César Álvarez Marcos ◽  
Manuel Florentino Fresno ◽  
...  
Keyword(s):  
P53 Protein ◽  
Squamous Metaplasia ◽  
Subsequent Development ◽  
Intestinal Type ◽  
Wood Dust ◽  
Precursor Lesions ◽  
Benign Lesions ◽  
Histological Changes ◽  
Adjacent Mucosa ◽  
Sinonasal Adenocarcinoma

Occupational exposure to wood dust is a strong risk factor for the development of intestinal-type sinonasal adenocarcinoma (ITAC); however, knowledge on possible precursor lesions or biomarkers is limited. Fifty-one samples of tumor-adjacent mucosa and 19 control samples of mucosa from the unaffected fossa of ITAC patients were evaluated for histological changes and p53 protein expression. Mild dysplasia was observed in 14%, cuboidal metaplasia in 57%, intestinal metaplasia in 8%, squamous metaplasia in 24%, and cylindrocellular hyperplasia in 53% of cases. P53 immunopositivity was generally weak occurring most frequently in squamous metaplasia. Wood dust etiology did not appear of influence on the histological changes, but p53 showed a tendency for higher positivity. Dysplasia adjacent to tumor was indicative of subsequent development of recurrence. In conclusion, precursor lesions do occur in mucosa adjacent to ITAC. This is clinically important, because it may justify the screening of high-risk individuals such as woodworkers.

scholarly journals Occurrence of Sinonasal Intestinal-Type Adenocarcinoma and Non-Intestinal-Type Adenocarcinoma in Two Countries with Different Patterns of Wood Dust Exposure

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5245
Author(s):  
Ilmo Leivo ◽  
Reetta Holmila ◽  
Danièle Luce ◽  
Torben Steiniche ◽  
Michael Dictor ◽  
...  
Keyword(s):  
Systematic Study ◽  
Diagnostic Workup ◽  
Intestinal Type ◽  
Dust Exposure ◽  
Wood Dust ◽  
Systematic Comparison ◽  
Sinonasal Adenocarcinoma ◽  
Intestinal Type Adenocarcinoma ◽  
Tumor Types

Sinonasal intestinal-type adenocarcinoma is strongly associated with hardwood dust exposure. Non-intestinal-type adenocarcinoma is a rarer and less well-known subtype considered not to be related with wood dust exposure. We determined the relative numbers of these two tumor types in 56 sinonasal adenocarcinoma patients in France and Finland, relating them with carefully assessed wood dust exposure histories. Diagnostic workup including immunohistochemistry for the intestinal markers CDX2 and CK20 indicated that the proportions of the two tumors differed significantly between France and Finland. In Finnish samples non-intestinal adenocarcinomas were more common than intestinal-type adenocarcinomas (12 non-intestinal vs. nine intestinal), while in the French samples the reverse was true (six non-intestinal vs. 29 intestinal). Such remarkably dissimilar occurrence of these tumors in France and Finland presumably reflects different pathogenetic circumstances in the two countries, and perhaps their different patterns of wood dust exposure. In France the main source of wood dust is from hardwoods. In Finland it is derived from softwoods. This is the first systematic comparison of the occurrence of intestinal-type adenocarcinoma and non-intestinal-type adenocarcinoma in two countries with different wood usage. It appears to be the first systematic study on differences in wood dust exposure between intestinal-type adenocarcinoma and non-intestinal-type adenocarcinoma.

Genetic and clinical aspects of wood dust related intestinal-type sinonasal adenocarcinoma: a review

2008 ◽  
Vol 266 (1) ◽  
pp. 1-7 ◽  
Author(s):  
José Luis Llorente ◽  
Jhudit Pérez-Escuredo ◽  
César Alvarez-Marcos ◽  
Carlos Suárez ◽  
Mario Hermsen
Keyword(s):  
Intestinal Type ◽  
Wood Dust ◽  
Clinical Aspects ◽  
Sinonasal Adenocarcinoma

Wood dust–related mutational profile of TP53 in intestinal-type sinonasal adenocarcinoma

2012 ◽  
Vol 43 (11) ◽  
pp. 1894-1901 ◽  
Author(s):  
Jhudit Pérez-Escuredo ◽  
Jorge García Martínez ◽  
Blanca Vivanco ◽  
César Álvarez Marcos ◽  
Carlos Suárez ◽  
...  
Keyword(s):  
Intestinal Type ◽  
Wood Dust ◽  
Sinonasal Adenocarcinoma

scholarly journals Rare Sinonasal Non-intestinal Type Adenocarcinoma of Right Nasal Septum

2019 ◽  
Vol 3 (1) ◽  
pp. 43
Author(s):  
Adam Mohamad ◽  
Baharudin Abdullah ◽  
Seoparjoo Azmel Mohd Isa ◽  
Norhafizah Abdul Rahim
Keyword(s):  
Nasal Septum ◽  
Young Male ◽  
Intestinal Type ◽  
Low Grade ◽  
Anatomic Structure ◽  
Respiratory Epithelial Adenomatoid Hamartoma ◽  
Seromucinous Hamartoma ◽  
Obstructive Sleep ◽  
Sinonasal Adenocarcinoma ◽  
The Right

Sinonasal tract is a complex anatomic structure with many possible diagnoses. Common diagnoses that usually encountered from the biopsied samples are inflammatory polyps and papillomas as well as squamous cell carcinoma. Another entity which most poorly understood is low grade glandular or tubular proliferations which includes reactive lesions, respiratory epithelial adenomatoid hamartoma, seromucinous hamartoma, and low grade sinonasal adenocarcinoma. We describe a case of a young male with right nasal septum mass which found incidentally upon flexible nasopharyngolaryngoscopic examination, who was referred earlier for possible obstructive sleep apnea. After excision of the tumour was done, it was confirmed to be low grade sinonasal adenocarcinoma non-intestinal type. This case highlights the rarity of the entitiy of low grade sinonasal adenocarcinoma nonintestinal type involving the right nasal septum; and how its subtle finding can be mistaken to be a clinically benign condition.International Journal of Human and Health Sciences Vol. 03 No. 01 January’19. Page : 43-46

scholarly journals A Case of the Low-Grade, Non-Intestinal type Sinonasal Adenocarcinoma of Nasal Septum

2017 ◽  
Vol 24 (1) ◽  
pp. 56
Author(s):  
Joo Hyun Shin ◽  
Ki Hwan Kwak ◽  
Jin Geol Lee ◽  
Tae Hoon Kim
Keyword(s):  
Nasal Septum ◽  
Intestinal Type ◽  
Low Grade ◽  
Sinonasal Adenocarcinoma

Primary carcinoid tumour of nasal septum

2008 ◽  
Vol 123 (7) ◽  
pp. 789-792 ◽  
Author(s):  
T Galm ◽  
N Turner
Keyword(s):  
Nasal Septum ◽  
World Literature ◽  
Carcinoid Syndrome ◽  
Carcinoid Tumour ◽  
Primary Tumour ◽  
Neck Region ◽  
Head And Neck Region ◽  
Carcinoid Tumours ◽  
History Of

AbstractObjective:We present the first reported case of primary carcinoid tumour of the nasal septum.Method:Case report of our experience of a carcinoid tumour of the nasal septum. We discuss our clinical, radiological and pathological findings.Result:An 83-year-old woman presented with a history of left-sided nasal blockage. Clinical examination showed a unilateral, left-sided nasal polyp. Further imaging and histological analysis confirmed this to be a carcinoid tumour. Carcinoid tumours outside the gastrointestinal tract are rare. There have been reports of carcinoid tumours in the head and neck region, but no published cases occurring in the nasal septum. Our management involved wide surgical resection with regular follow up to monitor for recurrence and for the development of carcinoid syndrome. Four years from initial presentation, the patient remained free of the primary tumour and had displayed no signs or symptoms suggestive of carcinoid syndrome.Conclusion:To the authors' best knowledge, and after searching the world literature, the presented case represents the first report of primary carcinoid tumour of the nasal septum. Despite its rarity, this tumour should be considered as part of the differential diagnosis, as timely recognition and intervention are critical for successful treatment.

Irresectable tumours of the temporal bone

1987 ◽  
Vol 101 (5) ◽  
pp. 432-442 ◽  
Author(s):  
R. E. Quiney ◽  
L. M. Flood
Keyword(s):  
Temporal Bone ◽  
Case Reports ◽  
Sporadic Case ◽  
Petrous Apex ◽  
Surgical Approaches ◽  
Total Removal ◽  
Inaccessible Area ◽  
History Of ◽  
Petrous Temporal Bone

AbstractSporadic case reports and the few published series of expanding lesions of the deep petrous temporal bone propose a variety of surgical approaches to ensure excision. All such surgery represents a compromise between exposure adequate for total removal and avoidance of further neurological deficit. Unfortunately pathology in the petrous apex evolves relatively silently and diagnosis is delayed. In many cases total excision is impossible. We present a series of patients presenting with advanced tumours of the deep petrous temporal bone in order to illustrate the spectrum of disease encountered, the limited role of surgery and the natural history of irresectable pathology in this remote and inaccessible area.

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