Combined laser in situ keratomileusis and prophylactic high-fluence corneal collagen crosslinking for high myopia: Two-year safety and efficacy

2015 ◽  
Vol 41 (7) ◽  
pp. 1426-1433 ◽  
Author(s):  
Anastasios John Kanellopoulos ◽  
George Asimellis
Keyword(s):  
High Myopia ◽  
Laser In Situ Keratomileusis ◽  
High Fluence ◽  
Safety And Efficacy ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

scholarly journals Corneal Collagen Crosslinking for Keratectasia after Laser in situ Keratomileusis: A Review of the Literature

2013 ◽  
Vol 2 (3) ◽  
pp. 113-120
Author(s):  
Leopoldo Spadea ◽  
Francesca Verboschi ◽  
Stefano Valente ◽  
Enzo Maria Vingolo
Keyword(s):  
Corneal Thickness ◽  
Laser In Situ Keratomileusis ◽  
Lamellar Keratoplasty ◽  
Review Of The Literature ◽  
Covalent Bonds ◽  
Collagen Crosslinking ◽  
Corneal Ectasia ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

ABSTRACT Corneal ectasia is a serious vision-threatening complication of laser in situ keratomileusis (LASIK). It is associated with progressive corneal steepening, an increase in myopia and astigmatism, and decrease in uncorrected visual acuity. Before LASIK presence of risk factors (corneal thickness, refractive error, presence of clinical and subclinical corneal pathologies) should be studied so patients should be risk-stratified. Forme fruste keratoconus or marginal pellucid degeneration should be investigated before LASIK in order to inform the patients of the possibility to develop a corneal complication. Management of post-LASIK ectasia enlists crosslinking, INTACTS, contact lenses and, in the most serious cases, lamellar keratoplasty and corneal transplantation. Crosslinking is a technique to treat and even prevent post-LASIK corneal ectasia. LASIK is a technique that reduces the corneal strength and stability. Crosslinking increases the number of collagen interfibrillar covalent bonds, using ultraviolet A and riboflavin. This result increases stability in corneal strength, reducing the risk to develop corneal ectasia (if performed simultaneously with LASIK) or it treats ectasia (if performed after LASIK keratectasia). How to cite this article Spadea L, Verboschi F, Valente S, Vingolo EM. Corneal Collagen Crosslinking for Keratectasia after Laser in situ Keratomileusis: A Review of the Literature. J Kerat Ect Cor Dis 2013;2(3):113-120.

Corneal collagen crosslinking for ectasia after laser in situ keratomileusis: Long-term results

2014 ◽  
Vol 40 (10) ◽  
pp. 1591-1596 ◽  
Author(s):  
Aydin Yildirim ◽  
Hanefi Cakir ◽  
Necip Kara ◽  
Hasim Uslu ◽  
Bulent Gurler ◽  
...  
Keyword(s):  
Long Term Results ◽  
Laser In Situ Keratomileusis ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

scholarly journals Compressional Optical Coherence Elastography of the Cornea

Photonics ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 111
Author(s):  
Manmohan Singh ◽  
Achuth Nair ◽  
Salavat R. Aglyamov ◽  
Kirill V. Larin
Keyword(s):  
Rabbit Model ◽  
Biomechanical Properties ◽  
Clinical Applications ◽  
Optical Coherence ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Biomechanical Properties ◽  
Corneal Collagen

Assessing the biomechanical properties of the cornea is crucial for detecting the onset and progression of eye diseases. In this work, we demonstrate the application of compression-based optical coherence elastography (OCE) to measure the biomechanical properties of the cornea under various conditions, including validation in an in situ rabbit model and a demonstration of feasibility for in vivo measurements. Our results show a stark increase in the stiffness of the corneas as IOP was increased. Moreover, UV-A/riboflavin corneal collagen crosslinking (CXL) also dramatically increased the stiffness of the corneas. The results were consistent across 4 different scenarios (whole CXL in situ, partial CXL in situ, whole CXL in vivo, and partial CXL in vivo), emphasizing the reliability of compression OCE to measure corneal biomechanical properties and its potential for clinical applications.

scholarly journals Silicone Hydrogel Miniscleral Contact Lenses after Corneal Collagen Crosslinking for Post-LASIK Keratoectasia

2014 ◽  
Vol 3 (3) ◽  
pp. 127-129
Author(s):  
Boris Severinsky
Keyword(s):  
Contact Lens ◽  
Contact Lenses ◽  
Visual Outcome ◽  
Visual Rehabilitation ◽  
Collagen Crosslinking ◽  
Silicone Hydrogel ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

ABSTRACT Purpose To report successful visual rehabilitation of post refractive surgery keratoectasia shortly after corneal collage crosslinking (CXL) procedure achieved with silicone hydrogel mini-scleral (SHmS) contact lens. Materials and methods A 29-year-old woman attended to our clinic with complaints on decreased vision in her left eye. Twelve years earlier she underwent bilateral laser-assisted in situ keratomileusis (LASIK) procedure for myopia correction. Corneal topography revealed bilateral central keratoectasia with maximal keratometry values of 55.4 Diopter (D) for her right eye and 59.7 D for the left, corneal thicknesses were 422 and 443 respectively. The patient underwent an uneventful CXL procedure in her left eye and was fitted with SHmS lens 5 weeks later. The lens was designed to rest over the patients’ sclera and perilimbal cornea and vault the central cornea with minimal support over it. Results SHmS lens fitting resulted in significant subjective improvement in visual acuity (from 20/200, unaided to 20/25, contact lens corrected). The patient was able to wear the lens upto 10 hours a day with stable contact lens corrected vision. No contact lens related complications, such as edema or neovascularization were observed during 3 months follow-up period. As a result of successful restoration of vision in the CXL-treated eye, the patient was scheduled for the procedure in her other eye. Conclusion SHmS contact lens should be considered as an option for the visual rehabilitation of corneas shortly after collagen corneal crosslinking procedure. This novel contact lens modality made from flexible and highly gas permeable material minimizes contact lens influence on corneal recovery after CXL and provides an excellent visual outcome. How to cite this article Severinsky B. Silicone Hydrogel Mini-scleral Contact Lenses after Corneal Collagen Crosslinking for Post-LASIK Keratoectasia. Int J Kerat Ect Cor Dis 2014;3(3):127-129.

scholarly journals MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of Keratoconus

2020 ◽  
Author(s):  
Mehrdad Mohammadpour ◽  
Ahmad Masoumi ◽  
Mahmoud Dehghan ◽  
Mohammad Nasser Hashemian ◽  
Shahab Addin Karami ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Corneal Stroma ◽  
Safety And Efficacy ◽  
Collagen Crosslinking ◽  
Randomized Controlled ◽  
Uncorrected Distance Visual Acuity ◽  
Corneal Collagen Crosslinking ◽  
The Mean ◽  
Corneal Collagen

Purpose: To evaluate the safety and efficacy of femtosecond laser-assisted MyoRing implantation with concurrent corneal collagen crosslinking (CXL) compared to MyoRing alone for the treatment of progressive keratoconus. Methods: A total of 60 patients were enrolled in this randomized controlled trial. The patients were randomly allocated into two groups. In the first group, MyoRing was implanted, while in the second, it was inserted in the corneal stroma using the same technique, along with simultaneous CXL. Visual, refractive, topographic, and abberometric outcomes were measured preoperatively and at every postoperative visit. Results: Data of 47 patients were available at the end of the study; 28 in the MyoRing group and 19 in the MyoRing + CXL group. The mean uncorrected distance visual acuity (UDVA) improved from 0.79 ± 0.39 logMAR to 0.52 ± 0.31 logMAR (P < 0.05) in the MyoRing + CXL group and from 0.65 ± 0.38 logMAR to 0.62 ± 0.23 logMAR (P = 0.70) in the MyoRing group. CDVA changed from 0.33 ± 0.19 logMAR to 0.25 ± 0.16 logMAR (P = 0.10) in the MyoRing + CXL group and 0.32 ± 0.22 logMAR to 0.33 ± 0.17 logMAR (P > 0.5) in the MyoRing group. The mean keratometry (Km) decreased from 47.5 ± 2.7 D to 43.8 ± 3.2 D (P < 0.001) in the MyoRing group and 49.3 ± 3.4 D to 45.1 ± 3.0 D (P < 0.001) in the MyoRing + CXL group. Besides, horizontal coma was significantly lower in the MyoRing + CXL group (P = 0.022). Conclusion: MyoRing insertion combined with CXL is a safe and effective method for the treatment of keratoconus. The visual and topographic outcomes were comparable to that for MyoRing insertion after 10 months; however, horizontal coma was significantly lower in the MyoRing + CXL group.

scholarly journals Corneal Epithelial Remodeling After Femtosecond Laser-Assisted in Situ Keratomileusis Combined with Intraoperative Accelerated Corneal Collagen Crosslinking for Myopia: A Retrospective Study

2021 ◽  
Author(s):  
Junjie Piao ◽  
Shen Wang ◽  
Ye Tao ◽  
Yue Hua Zhou ◽  
Ying Li
Keyword(s):  
Retrospective Study ◽  
Femtosecond Laser ◽  
Corneal Thickness ◽  
Corneal Epithelial ◽  
Collagen Crosslinking ◽  
Visual Outcomes ◽  
Corneal Collagen Crosslinking ◽  
Corneal Epithelial Thickness ◽  
Corneal Collagen

Abstract Background This study analyzed regional corneal thickness remodeling, biomechanical properties, and visual outcomes after femtosecond laser-assisted in situ keratomileusis combined with intraoperative accelerated corneal collagen crosslinking (LASIK Xtra) for myopia. Methods This retrospective study comprised 21 consecutive patients (18 women and 3 men; 42 eyes) who were treated with LASIK Xtra. All treatments were performed with ultraviolet-A (energy, 2.7 J/cm2; irradiance, 30 mW/cm2), using continuous (90 s) illumination. Postoperative values of corneal biometrics and visual outcomes were compared with preoperative values. Corneal thickness changes were evaluated using anterior segment optical coherence tomography. All patients were followed up for 12 months postoperatively. Preoperative and postoperative data were compared statistically using the paired t-test for normally distributed parameters and the Wilcoxon rank-sum test and Friedman analysis of variance with Bonferroni correction for non-normally distributed data. Results Uncorrected distance visual acuity (UDVA) significantly improved at 6 months after surgery (P < 0.001). The central and inner regional corneal epithelial thickness significantly increased after LASIK Xtra (P < 0.05 for all), while peripheral corneal epithelial thickness remained stable at 12 months after surgery. There was also a statistically significant decreased in the stromal thickness at most locations (P < 0.05 for all), except in the outer superior and outer superior-temporal regions. Conclusion LASIK Xtra provided predictable postoperative UDVA, corneal curvature, and corneal biomechanical stability. Since the retrospective study results depended on the cohort members’ past information, it is inferred and confirmed that regular corneal thickness remodeling occurred after treatment.

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