Decades-old windshield-glass perforating injury with limbal iris incarceration, zonular fiber defect, and equatorial lens capsule injury with capsule fibrosis and dense cataract

2017 ◽  
Vol 43 (11) ◽  
pp. 1478
Author(s):  
Rupert Menapace
2004 ◽  
Vol 221 (08) ◽  
pp. 622-628 ◽  
Author(s):  
F Kuhn ◽  
V Mester ◽  
R Morris

1995 ◽  
Vol 35 ◽  
pp. S199
Author(s):  
J.H. Meyer ◽  
J. Schmidt ◽  
F. Eppinger ◽  
B. Flügel ◽  
K.U. Löffler ◽  
...  

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1150
Author(s):  
Dixa Gautam ◽  
Michelle G. Pedler ◽  
Devatha P. Nair ◽  
Jonathan Mark Petrash

Cataracts are a leading cause of blindness worldwide. Surgical removal of cataracts is a safe and effective procedure to restore vision. However, a large number of patients later develop vision loss due to regrowth of lens cells and subsequent degradation of the visual axis leading to visual disability. This postsurgical complication, known as posterior capsular opacification (PCO), occurs in up to 30% of cataract patients and has no clinically proven pharmacological means of prevention. Despite the availability of many compounds capable of preventing early steps in PCO development, there is currently no effective means to deliver such therapies into the eye for a suitable duration. To model a solution to this unmet medical need, we fabricated acrylic substrates as intraocular lens (IOL) mimics scaled to place into the capsular bag of the mouse lens following a mock-cataract surgery. Substrates were coated with a hydrophilic crosslinked acrylate nanogel designed to elute Sorbinil, an aldose reductase inhibitor previously shown to suppress PCO. Insertion of the Sorbinil-eluting device into the lens capsule at the time of cataract surgery resulted in substantial prevention of cellular changes associated with PCO development. This model demonstrates that a cataract inhibitor can be delivered into the postsurgical lens capsule at therapeutic levels.


BMJ ◽  
1975 ◽  
Vol 3 (5982) ◽  
pp. 520-521 ◽  
Author(s):  
J R Collin
Keyword(s):  

2007 ◽  
Vol 47 (13) ◽  
pp. 1781-1789 ◽  
Author(s):  
R.M. Pedrigi ◽  
G. David ◽  
J. Dziezyc ◽  
J.D. Humphrey

1992 ◽  
Vol 54 (3) ◽  
pp. 393-401 ◽  
Author(s):  
George E. Marshall ◽  
Anastasios G.P. Konstas ◽  
Nikolaos E. Bechrakis ◽  
William R. Lee

1961 ◽  
Vol 52 (4) ◽  
pp. 463-468 ◽  
Author(s):  
Abraham L. Kornzweig ◽  
Frederick H. Theodore
Keyword(s):  

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