Development of optimized mucoadhesive thermosensitive pluronic based in situ gel for controlled delivery of Latanoprost: Antiglaucoma efficacy and stability approaches

2019 ◽  
Vol 53 ◽  
pp. 101134 ◽  
Author(s):  
Abeer Khattab ◽  
Sarah Marzok ◽  
Magdy Ibrahim
Keyword(s):  
Controlled Delivery ◽  
In Situ Gel

Formulation and evaluation of an in situ gel forming system for controlled delivery of triptorelin acetate

2011 ◽  
Vol 44 (4) ◽  
pp. 514-521 ◽  
Author(s):  
Sh. Abashzadeh ◽  
R. Dinarvand ◽  
M. Sharifzadeh ◽  
G. Hassanzadeh ◽  
M. Amini ◽  
...  
Keyword(s):  
Controlled Delivery ◽  
In Situ Gel ◽  
Triptorelin Acetate

In situ gel forming systems of poloxamer 407 and hydroxypropyl cellulose or hydroxypropyl methyl cellulose mixtures for controlled delivery of vancomycin

2008 ◽  
Vol 109 (4) ◽  
pp. 2369-2374 ◽  
Author(s):  
Azita H. H. Talasaz ◽  
Ali A. Ghahremankhani ◽  
Shadi H. Moghadam ◽  
Mazda R. Malekshahi ◽  
Fatemeh Atyabi ◽  
...  
Keyword(s):  
Methyl Cellulose ◽  
Hydroxypropyl Cellulose ◽  
Controlled Delivery ◽  
Poloxamer 407 ◽  
In Situ Gel ◽  
Hydroxypropyl Methyl Cellulose

Scaffolds for Drug Delivery in Tissue Engineering

2008 ◽  
Vol 1 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Vikas V. Gaikwad ◽  
Abasaheb B. Patil ◽  
Madhuri V. Gaikwad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Heart Diseases ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
The Body ◽  
Patient Specific ◽  
In Situ Gel ◽  
Heart Muscle Cells

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth.  Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.

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