Synergistic action of protease-modulating matrix and autologous growth factors in healing of diabetic foot ulcers. A prospective randomized trial

2007 ◽  
Vol 21 (6) ◽  
pp. 387-391 ◽  
Author(s):  
Despoina D. Kakagia ◽  
Konstantinos J. Kazakos ◽  
Konstantinos C. Xarchas ◽  
Michael Karanikas ◽  
George S. Georgiadis ◽  
...  
Keyword(s):  
Growth Factors ◽  
Randomized Trial ◽  
Diabetic Foot ◽  
Synergistic Action ◽  
Prospective Randomized Trial ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

scholarly journals The Efficacy and Safety of Dermagraft in Improving the Healing of Chronic Diabetic Foot Ulcers: Results of a prospective randomized trial

Diabetes Care ◽  
2003 ◽  
Vol 26 (6) ◽  
pp. 1701-1705 ◽  
Author(s):  
W. A. Marston ◽  
J. Hanft ◽  
P. Norwood ◽  
R. Pollak
Keyword(s):  
Randomized Trial ◽  
Diabetic Foot ◽  
Prospective Randomized Trial ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Efficacy And Safety

Growth factors for treating diabetic foot ulcers

2010 ◽  
Author(s):  
Arturo J Martí-Carvajal ◽  
Maria Ximena Rojas-Reyes ◽  
Ludovic Reveiz ◽  
Nelcy Rodriguez-Malagon ◽  
Jorge Cedeño-Taborda
Keyword(s):  
Growth Factors ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

New and Alternative Treatments for Diabetic Foot Ulcers: Hormones and Growth Factors

2006 ◽  
pp. 214-221 ◽  
Author(s):  
Matthew J. Hardman ◽  
Gillian S. Ashcroft
Keyword(s):  
Growth Factors ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Alternative Treatments

scholarly journals The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-18 ◽  
Author(s):  
Elahe Mahdipour ◽  
Amirhossein Sahebkar
Keyword(s):  
Systematic Review ◽  
Growth Factors ◽  
Growth Factor ◽  
Recombinant Proteins ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Controlled Trials ◽  
Diabetic Foot Ulcers ◽  
Randomized Controlled

Background. Recombinant proteins and growth factors are emerging therapies for diabetic foot ulcers. Despite several clinical reports, there has been no comprehensive and systematic assessment of the totality of clinical evidence on the efficacy and safety of recombinant proteins and growth factors in diabetic foot ulcers. We tried to address this gap through an updated systematic review of randomized controlled trials (RCTs). Methods. PubMed, the Cochrane Library, Scopus, Embase, and Google Scholar databases were searched, and RCTs on the efficacy of recombinant proteins and growth factors in the treatment of cutaneous wounds in diabetic patients were selected. The literature search and assessment were performed by two independent reviewers. Methodological quality of studies was appraised using the Jadad scale. Results. We identified 26 RCTs involving diabetic patients with ulcer that evaluated the effectiveness of platelet-derived growth factor, epidermal growth factor, fibroblast growth factor, granulocyte colony-stimulating factor, vascular endothelial growth factor, erythropoietin, transforming growth factor, talactoferrin, and rusalatide acetate. The main primary outcome was complete healing though different indices were employed to define this such as wound closure, granulation tissue formation, or complete reepithelialization. Few studies had a follow-up period to report any recurrence and amputation rate. No adverse effect was reported due to the intervention. Conclusion. Overall, there is a greater agreement on the effectiveness of EGF to enhance the healing of diabetic ulcers. Nevertheless, extant evidence is lacking for other agents since few trials have been conducted for most of the growth factors and available studies are heterogeneous in their methodologies.

Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers

2006 ◽  
Vol 14 (5) ◽  
pp. 558-565 ◽  
Author(s):  
Hanna Galkowska ◽  
Urszula Wojewodzka ◽  
Waldemar L. Olszewski
Keyword(s):  
Endothelial Cells ◽  
Growth Factors ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

scholarly journals Topical administration of a connexin43‐based peptide augments healing of chronic neuropathic diabetic foot ulcers: A multicenter, randomized trial

2015 ◽  
Vol 23 (2) ◽  
pp. 203-212 ◽  
Author(s):  
Christina L. Grek ◽  
G.M. Prasad ◽  
Vijay Viswanathan ◽  
David G. Armstrong ◽  
Robert G. Gourdie ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Diabetic Foot ◽  
Topical Administration ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Multicenter Randomized Trial

scholarly journals A Randomized Trial of Two Irremovable Off-Loading Devices in the Management of Plantar Neuropathic Diabetic Foot Ulcers

Diabetes Care ◽  
2005 ◽  
Vol 28 (3) ◽  
pp. 555-559 ◽  
Author(s):  
I. A. Katz ◽  
A. Harlan ◽  
B. Miranda-Palma ◽  
L. Prieto-Sanchez ◽  
D. G. Armstrong ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Loading Devices
Sign in / Sign up

Export Citation Format

Share Document