Efficient electrochemical sensor for determination of H2O2 in human serum based on nano iron‑nickel alloy/carbon nanotubes/ionic liquid crystal composite

A novel, reliable electrochemical sensor is fabricated for direct and sensitive determination of norepinephrine (NE) based on gold nanoparticles, ionic liquid crystal, and β-cyclodextrin modified carbon paste electrode, namely AuILCCDCPE. The ionic liquid crystal (ILC) played a key role in improving the current response of electro-oxidation of NE compared with other ionic liquids modified electrodes. The ILC increased the ionic conductivity of the paste and formed noncovalent interactions with both host (CD) and guest (NE) compounds. The solid state structure of the ILC helped in the formation of ordered films in the paste. Furthermore, CD and Au nanoparticles raised the stability and the electrocatalytic ability of the proposed sensor. Under optimized conditions, the fabricated electrochemical sensor showed a good electrochemical response towards NE in human urine in the linear dynamic ranges of 0.05–10 μmol/L and 20–300 μmol/L with a correlation coefficient of 0.999 and detection limit of 3.12 × 10−9 mol/L in the low concentration range. The practical analytical performance of the sensor was attained for determination of NE in real samples with satisfied recovery results. This sensor has great ability to be extended for electrochemical applications in assays of other drugs.

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Hematite Nanoparticles/Ionic Liquid Crystal/Graphene–Based Nanocomposite Electrochemical Sensor for Sensitive Determination of Antipsychotic Drug

Journal of The Electrochemical Society ◽

10.1149/2.1101613jes ◽

2016 ◽

Vol 163 (14) ◽

pp. B659-B666 ◽

Cited By ~ 18

Author(s):

Nada F. Atta ◽

Yousef M. Ahmed ◽

Mohammad H. BinSabt ◽

Ahmed Galal

Keyword(s):

Ionic Liquid ◽

Liquid Crystal ◽

Electrochemical Sensor ◽

Antipsychotic Drug ◽

Hematite Nanoparticles ◽

Sensitive Determination

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Efficient Electrochemical Sensor Based on Gold Nanoclusters/Carbon Ionic Liquid Crystal for Sensitive Determination of Neurotransmitters and Anti-Parkinson Drugs

Advanced Pharmaceutical Bulletin ◽

10.15171/apb.2020.006 ◽

2019 ◽

Vol 10 (1) ◽

pp. 46-55 ◽

Cited By ~ 1

Author(s):

Nada Farouk Atta ◽

Ahmed Galal ◽

Ekram Hamdy El-Ads ◽

Aya Essam Galal

Keyword(s):

Ionic Liquid ◽

Liquid Crystal ◽

Electrochemical Sensor ◽

Gold Nanoclusters ◽

Electrochemical Determination ◽

Electrochemical Sensing ◽

Current Response ◽

Carbon Paste ◽

Electro Catalytic Oxidation

Purpose: Herein we introduce a simple and sensitive sensor for the electrochemical determination of neurotransmitters compounds and anti-Parkinson drugs. Methods: The electrochemical sensor (Au/CILCE) based on gold nanoclusters modified carbon ionic liquid crystal (ILC) electrode was characterized using scanning electron microscopy and voltammetry measurements. Results: The effect of ionic liquid type in the carbon paste composite for the electro-catalytic oxidation of L-dopa was evaluated. Highest current response was obtained in case of ILC compared to other studied kinds of ionic liquids. The effective combination of gold nanoclusters and ILC resulted in extra advantages including large surface area and high ionic conductivity of the nanocomposite. L-dopa is considered one of the most important prescribed medicines for treating Parkinson’s disease. Moreover, a binary therapy using L-dopa and carbidopa proved effective and promising as it avoids the short comings of L-dopa mono-therapy for Parkinson’s patients. The Au/CILCE can detect L-dopa in human serum in the linear concentration range of 0.1 μM to 90 μM with detection and quantification limits of 4.5 nM and 15.0 nM, respectively. Also, the Au/CILCE sensor can simultaneously and sensitively detect L-dopa in the presence of carbidopa with low detection limits. Conclusion: The sensor is advantageous to be applicable for electrochemical sensing of other biologically electroactive species.

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