Ultrasensitive determination of nalbuphine and tramadol narcotic analgesic drugs for postoperative pain relief using nano-cobalt oxide/ionic liquid crystal/carbon nanotubes-based electrochemical sensor

2019 ◽  
Vol 839 ◽  
pp. 48-58 ◽  
Author(s):  
Nada F. Atta ◽  
Ahmed Galal ◽  
Samar H. Hassan
Keyword(s):  
Carbon Nanotubes ◽  
Ionic Liquid ◽  
Liquid Crystal ◽  
Postoperative Pain ◽  
Pain Relief ◽  
Electrochemical Sensor ◽  
Cobalt Oxide ◽  
Narcotic Analgesic ◽  
Analgesic Drugs

scholarly journals Cobalt Oxide Nanoparticles/Graphene/Ionic Liquid CrystalModified Carbon Paste Electrochemical Sensor for Ultra-sensitiveDetermination of a Narcotic Drug

2019 ◽  
Vol 9 (1) ◽  
pp. 110-121 ◽  
Author(s):  
Nada Farouk Atta ◽  
Ahmed Galal ◽  
Ekram Hamdy El-Ads ◽  
Samar Hamed Hassan
Keyword(s):  
Ionic Liquid ◽  
Electrochemical Sensor ◽  
Cobalt Oxide ◽  
Dynamic Range ◽  
Electrochemical Impedance ◽  
Oxide Nanoparticles ◽  
Carbon Paste ◽  
Great Ability ◽  
Cobalt Oxide Nanoparticles

Purpose: Drug-abuse, namely morphine (MO) affects the metabolism of neurotransmitterssuch as dopamine (DA). Therefore, it is crucial to devise a sensitive sensing technique tosimultaneously determine both compounds in real samples.Methods: The fabrication of the sensor is based on in situ modification of a carbon paste (CP)electrode with cobalt oxide nanoparticles, graphene, and ionic liquid crystal in presence ofsodium dodecyl sulfate; CoGILCCP-SDS. The modified sensor is characterized using scanningelectron microscopy, electrochemical impedance spectroscopy and voltammetry measurements.Results: Electron transfer kinetics and analytical performance of the proposed sensor wereenhanced due to the synergistic role of all the modifiers. The simultaneous determination of MOand DA achieved low detection limits of 0.54 nmol L−1 and 0.25 nmol L−1, respectively. Besides,a carbon-based electrochemical sensor is fabricated for the nano-molar determination of MOin real samples and formulations. The sensor showed fouling resistance and anti-interferenceability in presence of other species in human fluids. The real sample analysis of MO wassuccessfully achieved with good recovery results in urine samples and pharmaceutical tablets.Linear dynamic range, sensitivity, detection limit and quantification limit of MO in urine were5 nmol L−1 to 0.6 μmol L−1, 6.19 μA/μmol L-1, 0.484 nmol L−1 and 1.61 nmol L−1, respectively.Conclusion: This sensor has great ability to be extended for electrochemical applications inassaying of many drugs.

Electrochemical sensor based on incorporation of gold nanoparticles, ionic liquid crystal, and β-cyclodextrin into carbon paste composite for ultra-sensitive determination of norepinephrine in real samples

2019 ◽  
Vol 97 (12) ◽  
pp. 805-814
Author(s):  
Nada F. Atta ◽  
Ahmed Galal ◽  
Dalia M. El-Said
Keyword(s):  
Gold Nanoparticles ◽  
Ionic Liquid ◽  
Liquid Crystal ◽  
Electrochemical Sensor ◽  
Current Response ◽  
Carbon Paste ◽  
Great Ability ◽  
Real Samples ◽  
Sensitive Determination

A novel, reliable electrochemical sensor is fabricated for direct and sensitive determination of norepinephrine (NE) based on gold nanoparticles, ionic liquid crystal, and β-cyclodextrin modified carbon paste electrode, namely AuILCCDCPE. The ionic liquid crystal (ILC) played a key role in improving the current response of electro-oxidation of NE compared with other ionic liquids modified electrodes. The ILC increased the ionic conductivity of the paste and formed noncovalent interactions with both host (CD) and guest (NE) compounds. The solid state structure of the ILC helped in the formation of ordered films in the paste. Furthermore, CD and Au nanoparticles raised the stability and the electrocatalytic ability of the proposed sensor. Under optimized conditions, the fabricated electrochemical sensor showed a good electrochemical response towards NE in human urine in the linear dynamic ranges of 0.05–10 μmol/L and 20–300 μmol/L with a correlation coefficient of 0.999 and detection limit of 3.12 × 10−9 mol/L in the low concentration range. The practical analytical performance of the sensor was attained for determination of NE in real samples with satisfied recovery results. This sensor has great ability to be extended for electrochemical applications in assays of other drugs.

scholarly journals Efficient Electrochemical Sensor Based on Gold Nanoclusters/Carbon Ionic Liquid Crystal for Sensitive Determination of Neurotransmitters and Anti-Parkinson Drugs

2019 ◽  
Vol 10 (1) ◽  
pp. 46-55 ◽  
Author(s):  
Nada Farouk Atta ◽  
Ahmed Galal ◽  
Ekram Hamdy El-Ads ◽  
Aya Essam Galal
Keyword(s):  
Ionic Liquid ◽  
Liquid Crystal ◽  
Electrochemical Sensor ◽  
Gold Nanoclusters ◽  
Electrochemical Determination ◽  
Electrochemical Sensing ◽  
Current Response ◽  
Carbon Paste ◽  
Electro Catalytic Oxidation

Purpose: Herein we introduce a simple and sensitive sensor for the electrochemical determination of neurotransmitters compounds and anti-Parkinson drugs. Methods: The electrochemical sensor (Au/CILCE) based on gold nanoclusters modified carbon ionic liquid crystal (ILC) electrode was characterized using scanning electron microscopy and voltammetry measurements. Results: The effect of ionic liquid type in the carbon paste composite for the electro-catalytic oxidation of L-dopa was evaluated. Highest current response was obtained in case of ILC compared to other studied kinds of ionic liquids. The effective combination of gold nanoclusters and ILC resulted in extra advantages including large surface area and high ionic conductivity of the nanocomposite. L-dopa is considered one of the most important prescribed medicines for treating Parkinson’s disease. Moreover, a binary therapy using L-dopa and carbidopa proved effective and promising as it avoids the short comings of L-dopa mono-therapy for Parkinson’s patients. The Au/CILCE can detect L-dopa in human serum in the linear concentration range of 0.1 μM to 90 μM with detection and quantification limits of 4.5 nM and 15.0 nM, respectively. Also, the Au/CILCE sensor can simultaneously and sensitively detect L-dopa in the presence of carbidopa with low detection limits. Conclusion: The sensor is advantageous to be applicable for electrochemical sensing of other biologically electroactive species.

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