scholarly journals Angelica sinensis extract protects against ischemia-reperfusion injury in the hippocampus by activating p38 MAPK-mediated p90RSK/p-Bad and p90RSK/CREB/BDNF signaling after transient global cerebral ischemia in rats

2020 ◽  
Vol 252 ◽  
pp. 112612 ◽  
Author(s):  
Chin-Yi Cheng ◽  
Shung-Te Kao ◽  
Yu-Chen Lee
Keyword(s):  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
P38 Mapk ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Global Cerebral Ischemia ◽  
Angelica Sinensis ◽  
Transient Global Cerebral Ischemia ◽  
Bdnf Signaling

scholarly journals Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils

2002 ◽  
Vol 8 (5) ◽  
pp. 253-256 ◽  
Author(s):  
Ling Li ◽  
Zhiqiang Shen ◽  
Weimin Yang ◽  
Wanling Wu ◽  
Weiping Liu ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Lipid Peroxide ◽  
Superoxide Dismutase Activity ◽  
Global Cerebral Ischemia ◽  
Peroxide Content ◽  
Copper Aspirinate

The cerebroprotective effects of copper aspirinate [dimeric copper(II) bis(o-acetoxybenzoate)] were investigated in gerbils subjected to 10-min global cerebral ischemia followed b 60-min reperfusion. The results showed that intragastric copper aspirinate (7.5, 15.0 and 30.0 mg Kg−1 ) markedly promoted the recovery of the electroencephalogram amplitude, attenuated the increase of lipid peroxide content and the decrease of superoxide dismutase activity in the cortex during ischemia-reperfusion injury. It suggested that copper aspirinate possesses potential neuroprotective properties, the mechanism of which might be related to an increase of the activity of endogenous superoxide dismutase.

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