Predictors of mortality and length of stay in patients with hospital-acquired Clostridioides difficile infection: a population-based study in Alberta, Canada

2019 ◽  
Vol 103 (1) ◽  
pp. 85-91 ◽  
Author(s):  
J. Leal ◽  
P. Ronksley ◽  
E.A. Henderson ◽  
J. Conly ◽  
B. Manns
Keyword(s):  
Length Of Stay ◽  
Population Based ◽  
Population Based Study ◽  
Predictors Of Mortality ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection ◽  
Hospital Acquired

Burden of community-associated Clostridioides difficile infection in southeastern United States: a population-based study

Infection ◽  
2019 ◽  
Vol 48 (1) ◽  
pp. 129-132 ◽  
Author(s):  
Mariam Younas ◽  
Julie Royer ◽  
Sharon B. Weissman ◽  
Katie S. Waites ◽  
Sangita Dash ◽  
...  
Keyword(s):  
United States ◽  
Southeastern United States ◽  
Population Based ◽  
Population Based Study ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection

Mo1936 CLOSTRIDIOIDES DIFFICILE INFECTION IN PATIENTS WITH LIVER CIRRHOSIS IN THE USA: A POPULATION BASED STUDY

2020 ◽  
Vol 158 (6) ◽  
pp. S-984
Author(s):  
Mohammad Abureesh ◽  
Motasem Alkhayyat ◽  
Shivantha Amarnath ◽  
Rawan Badran ◽  
Vivek Gumaste
Keyword(s):  
Liver Cirrhosis ◽  
Population Based ◽  
Population Based Study ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection ◽  
The Usa

scholarly journals Clostridioides difficile infection in liver cirrhosis patients: A population-based study in United States

2021 ◽  
Vol 13 (8) ◽  
pp. 926-938
Author(s):  
Syeda Sahra ◽  
Mohammad Abureesh ◽  
Shivantha Amarnath ◽  
Motasem Alkhayyat ◽  
Rawan Badran ◽  
...  
Keyword(s):  
United States ◽  
Liver Cirrhosis ◽  
Population Based ◽  
Population Based Study ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection

Attributable costs and length of stay of hospital-acquired Clostridioides difficile: A population-based matched cohort study in Alberta, Canada

2019 ◽  
Vol 40 (10) ◽  
pp. 1135-1143 ◽  
Author(s):  
Jenine R. Leal ◽  
John Conly ◽  
Robert Weaver ◽  
James Wick ◽  
Elizabeth A. Henderson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Length Of Stay ◽  
Propensity Score ◽  
Length Of Hospital Stay ◽  
Population Based ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Clostridioides Difficile ◽  
Hospital Acquired ◽  
Incident Cases

AbstractObjective:To determine the attributable cost and length of stay of hospital-acquired Clostridioides difficile infection (HA-CDI) from the healthcare payer perspective using linked clinical, administrative, and microcosting data.Design:A retrospective, population-based, propensity-score–matched cohort study.Setting:Acute-care facilities in Alberta, Canada.Patients:Admitted adult (≥18 years) patients with incident HA-CDI and without CDI between April 1, 2012, and March 31, 2016.Methods:Incident cases of HA-CDI were identified using a clinical surveillance definition. Cases were matched to noncases of CDI (those without a positive C. difficile test or without clinical CDI) on propensity score and exposure time. The outcomes were attributable costs and length of stay of the hospitalization where the CDI was identified. Costs were expressed in 2018 Canadian dollars.Results:Of the 2,916 HA-CDI cases at facilities with microcosting data available, 98.4% were matched to 13,024 noncases of CDI. The total adjusted cost among HA-CDI cases was 27% greater than noncases of CDI (ratio, 1.27; 95% confidence interval [CI], 1.21–1.33). The mean attributable cost was $18,386 (CAD 2018; USD $14,190; 95% CI, $14,312–$22,460; USD $11,046-$17,334). The adjusted length of stay among HA-CDI cases was 13% greater than for noncases of CDI (ratio, 1.13; 95% CI, 1.07–1.19), which corresponds to an extra 5.6 days (95% CI, 3.10–8.06) in length of hospital stay per HA-CDI case.Conclusions:In this population-based, propensity score matched analysis using microcosting data, HA-CDI was associated with substantial attributable cost.

Mo1920 EPIDIMIOLOGY AND TREND ANALYSIS OF CLOSTRIDIOIDES DIFFICILE INFECTION 2002-2014: A POPULATION-BASED STUDY

2020 ◽  
Vol 158 (6) ◽  
pp. S-977-S-978
Author(s):  
Muhammad Talal Sarmini ◽  
Mohammad Maysara Asfari ◽  
George Khoudari ◽  
Emad Mansoor ◽  
Kenneth J. Vega
Keyword(s):  
Trend Analysis ◽  
Population Based ◽  
Population Based Study ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection

scholarly journals Incidence and economic burden of Clostridioides difficile infection in Ontario: a retrospective population-based study

CMAJ Open ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. E16-E25 ◽  
Author(s):  
Jennifer A. Pereira ◽  
Allison McGeer ◽  
Antigona Tomovici ◽  
Alex Selmani ◽  
Ayman Chit
Keyword(s):  
Economic Burden ◽  
Population Based ◽  
Population Based Study ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection

scholarly journals The interplay of SARS-CoV-2 and Clostridioides difficile infection

2021 ◽  
Vol 16 (6) ◽  
pp. 439-443
Author(s):  
Sahil Khanna ◽  
Colleen S Kraft
Keyword(s):  
High Risk ◽  
Infection Control ◽  
Gastrointestinal Symptoms ◽  
Control Measures ◽  
Antibiotic Exposure ◽  
Hospital Acquired Infections ◽  
Infection Control Measures ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection ◽  
Hospital Acquired

The COVID-19 pandemic has changed the way we practice medicine and lead our lives. In addition to pulmonary symptoms; COVID-19 as a syndrome has multisystemic involvement including frequent gastrointestinal symptoms such as diarrhea. Due to microbiome alterations with COVID-19 and frequent antibiotic exposure, COVID-19 can be complicated by Clostridioides difficile infection. Co-infection with these two can be associated with a high risk of complications. Infection control measures in hospitals is enhanced due to the COVID-19 pandemic which in turn appears to reduce the incidence of hospital-acquired infections such as C. difficile infection. Another implication of COVID-19 and its potential transmissibility by stool is microbiome-based therapies. Potential stool donors should be screened COVID-19 symptoms and be tested for COVID-19.

Using diagnostic stewardship to reduce rates, healthcare expenditures and accurately identify cases of hospital-onset Clostridioides difficile infection

2020 ◽  
Vol 42 (1) ◽  
pp. 51-56
Author(s):  
Dipesh Solanky ◽  
Derek K. Juang ◽  
Scott T. Johns ◽  
Ian C. Drobish ◽  
Sanjay R. Mehta ◽  
...  
Keyword(s):  
Healthcare Facility ◽  
Nucleic Acid Amplification ◽  
Fiscal Year ◽  
Hospital Acquired Infection ◽  
Laxative Use ◽  
Clostridioides Difficile ◽  
Hospitalization Costs ◽  
Clostridioides Difficile Infection ◽  
Hospital Acquired ◽  
Hospital Days

AbstractObjective:Lack of judicious testing can result in the incorrect diagnosis of Clostridioides difficile infection (CDI), unnecessary CDI treatment, increased costs and falsely augmented hospital-acquired infection (HAI) rates. We evaluated facility-wide interventions used at the VA San Diego Healthcare System (VASDHS) to reduce healthcare-onset, healthcare-facility–associated CDI (HO-HCFA CDI), including the use of diagnostic stewardship with test ordering criteria.Design:We conducted a retrospective study to assess the effectiveness of measures implemented to reduce the rate of HO-HCFA CDI at the VASDHS from fiscal year (FY)2015 to FY2018.Interventions:Measures executed in a stepwise fashion included a hand hygiene initiative, prompt isolation of CDI patients, enhanced terminal room cleaning, reduction of fluoroquinolone and proton-pump inhibitor use, laboratory rejection of solid stool samples, and lastly diagnostic stewardship with C. difficile toxin B gene nucleic acid amplification testing (NAAT) criteria instituted in FY2018.Results:From FY2015 to FY2018, 127 cases of HO-HCFA CDI were identified. All rate-reducing initiatives resulted in decreased HO-HCFA cases (from 44 to 13; P ≤ .05). However, the number of HO-HCFA cases (34 to 13; P ≤ .05), potential false-positive testing associated with colonization and laxative use (from 11 to 4), hospital days (from 596 to 332), CDI-related hospitalization costs (from $2,780,681 to $1,534,190) and treatment cost (from $7,158 vs $1,476) decreased substantially following the introduction of diagnostic stewardship with test criteria from FY2017 to FY2018.Conclusions:Initiatives to decrease risk for CDI and diagnostic stewardship of C. difficile stool NAAT significantly reduced HO-HCFA CDI rates, detection of potential false-positives associated with laxative use, and lowered healthcare costs. Diagnostic stewardship itself had the most dramatic impact on outcomes observed and served as an effective tool in reducing HO-HCFA CDI rates.

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