Dual Inhibitors of Interleukin-6 and Acetylcholinesterase for treatment of Alzheimer's Disease: Design, Docking, Synthesis and Biological Evaluation

Journal of the Indian Chemical Society ◽

10.1016/j.jics.2021.100165 ◽

2021 ◽

pp. 100165

Author(s):

Sukhvir Kaur ◽

Yogita Bansal

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Interleukin 6 ◽

Biological Evaluation ◽

Dual Inhibitors ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer’s disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112475 ◽

2020 ◽

Vol 202 ◽

pp. 112475

Author(s):

Sai-Sai Xie ◽

Jing Liu ◽

Chunli Tang ◽

Chengyun Pang ◽

Qing Li ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase B ◽

Design Synthesis ◽

Dual Inhibitors ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113554 ◽

2021 ◽

pp. 113554

Author(s):

Wenwu Liu ◽

Xin Liu ◽

Liting Tian ◽

Yaping Gao ◽

Wenjie Liu ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Dual Inhibitors ◽

Gsk 3Β ◽

Synthesis And Biological Evaluation

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Phthalimide‐(N‐alkylbenzylamine) cysteamide hybrids as multifunctional agents against Alzheimer’s disease: Design, synthesis and biological evaluation

Chemical Biology & Drug Design ◽

10.1111/cbdd.13905 ◽

2021 ◽

Author(s):

Heng Zhang ◽

Qing Song ◽

Guangjun Yu ◽

Zhongcheng Cao ◽

Xiaoming Qiang ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Multifunctional Agents ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of novel radioiodinated imidazopyridine derivatives for amyloid-β imaging in Alzheimer’s disease

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.05.043 ◽

2014 ◽

Vol 22 (15) ◽

pp. 4189-4197 ◽

Author(s):

Chun-Jen Chen ◽

Kazunori Bando ◽

Hiroki Ashino ◽

Kazumi Taguchi ◽

Hideaki Shiraishi ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Imidazopyridine Derivatives ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.02.063 ◽

2018 ◽

Vol 149 ◽

pp. 129-138 ◽

Author(s):

Yuying Fang ◽

Wenjuan Xia ◽

Bao Cheng ◽

Pei Hua ◽

Huihao Zhou ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer’s disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112751 ◽

2020 ◽

Vol 207 ◽

pp. 112751

Author(s):

Xueyang Jiang ◽

Junting Zhou ◽

Yang Wang ◽

Lei Chen ◽

Yan Duan ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Rational Design ◽

Biological Evaluation ◽

New Class ◽

Dual Inhibitors

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Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.07.031 ◽

2019 ◽

Vol 180 ◽

pp. 367-382 ◽

Author(s):

Changjun Zhang ◽

Ke Yang ◽

Sihang Yu ◽

Jing Su ◽

Shengli Yuan ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase B ◽

Iron Chelates ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of 3-arylbenzofuranone derivatives as potential anti-Alzheimer’s disease agents

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/14756366.2020.1740694 ◽

2020 ◽

Vol 35 (1) ◽

pp. 805-814 ◽

Author(s):

Jie Yang ◽

Yinling Yun ◽

Yuhang Miao ◽

Jie Sun ◽

Xiaojing Wang

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of ranitidine analogs as multiple-target-directed cognitive enhancers for the treatment of Alzheimer’s disease

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2016.09.072 ◽

2016 ◽

Vol 26 (22) ◽

pp. 5573-5579 ◽

Author(s):

Jie Gao ◽

Narasimha Midde ◽

Jun Zhu ◽

Alvin V. Terry ◽

Campbell McInnes ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Multiple Target ◽

Cognitive Enhancers ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer’s Disease

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.8b00376 ◽

2018 ◽

Vol 10 (1) ◽

pp. 537-551 ◽

Author(s):

Jinhui Hu ◽

Ya-Dan Huang ◽

Tingting Pan ◽

Tianhua Zhang ◽

Tao Su ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

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